Observing a lot by just watching: Advances in biological imaging across multiple scales

Historically, imaging has been a cornerstone of biomedical research, providing indispensable insights into the complexity of life — from intricate anatomical structures to dynamic biochemical processes. Imaging modalities span vast spatial and temporal scales, enabling scientists to observe real-time cellular dynamics, visualize subcellular structures and characterize molecular architecture with unprecedented clarity.

Recent advancements have significantly broadened the scope and capability of imaging technologies. Innovations in super-resolution microscopy have shattered traditional resolution barriers, making it possible to visualize biological processes at near-molecular detail within living cells. Developments in label-free optical imaging have further allowed for the observation of biological specimens without perturbation from external markers, preserving natural states and processes. Additionally, cryo-electron microscopy (Cryo-EM) has revolutionized structural biology, providing atomic-resolution images of biomolecules and complexes previously beyond the reach of conventional imaging methods. Single-molecule imaging techniques have also emerged as powerful tools, enabling the observation of individual molecular events and interactions, thus providing unprecedented insights into molecular dynamics and function.

This session will highlight these and other cutting-edge developments, showcasing how novel imaging technologies across different scales are transforming our approach to biological research. Emphasis will be placed on both methodological innovations and their powerful applications to fundamental questions in biology, demonstrating how advanced imaging continues to shape and enhance our understanding of life's complexities.

Organizers

Mario J. Borgnia
National Institute of Environmental Health Sciences

Rinku Jain
AbbVie Inc.

Kevin Welsher
Duke University