Subcellular sphingolipids and ceramides in organelle function
The subcellular distribution and function of lipids remains a serious challenge to understanding biology. Two student presentations at a recent scientific conference highlighted a new innovation in mass spectrometry that improves organelle identification and a new function for ceramide-dependent mitophagy associated with aging in T cells. A committee of established ASBMB members selected these two innovative and exciting presentations for this LRD seminar.
- Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
Mohamed Faisal Kassir, Medical University of South Carolina
- High-resolution secondary ion mass spectrometry (SIMS) imaging of intracellular lipid distributions
Brittney L. Gorman, University of Illinois Urbana–Champaign