Aug. 14–18, 2022 | Cambridge, Mass.

Mass Spectrometry in the Health and Life Sciences

The 14th International Symposium on Mass Spectrometry in the Health and Life Sciences
Aug. 14–18, 2022 | Broad Institute of MIT and Harvard, Cambridge, Mass.

This five-day hybrid symposium will be held at the Broad Institute in Cambridge, Mass., and provides the option to register for in-person attendance or virtual participation. The symposium will be an international forum for discussion of the remarkable advances in cell and human protein biology revealed by ever-more-innovative and powerful mass spectrometric technologies.

The presenters we’ve invited are pioneers in the field: Some have made major contributions to the development of methodologies, while others have applied proteomic techniques to solve major problems facing cell biology and medicine.

The symposium will juxtapose sessions about methodological advances with sessions about the roles those advances play in solving problems and seizing opportunities to understand the composition, dynamics and function of cellular machinery in numerous biological contexts. In addition to celebrating these successes, we also intend to articulate urgent, unmet needs and unsolved problems that will drive the field in the future.

In addition to talks by invited plenary and session speakers, short talks will be selected from submitted abstracts.

All talks and posters will be presented in person. Participants can register to attend the symposium in person or virtually — virtual registration provides access to the talks only.

Sessions

Minisymposium (Sunday): Toward single cell investigations

Main symposium (Monday–Thursday)

  1. Emerging technologies: Sample preparation and automation
  2. Emerging technologies: Instrumentation and data generation methods
  3. Proteomics in structural biology and integration with other high resolution methods
  4. Interactomics: Understanding pathways, networks and molecular machines
  5. Chemical biology and chemoproteomics: toward functional understanding of drugs and their targets
  6. Cell, organellar and tissue biology: signaling, cross talk and communication
  7. Impact of clinical and translational proteomics in human health and treatment
  8. Multiomics integrative analysis and the emerging roles of machine learning and neural models

Important dates

July 1 In-person registration deadline
Aug. 12 Virtual registration deadline

Organizers

A. L. Burlingame University of California, San Francisco
Steven Carr Broad Institute of MIT and Harvard
Bernhard Küster Technical University of Munich
Interview

A hybrid symposium on mass spec

Co-organizer Bernhard Küster talked to ASBMB Today about the symposium and what participants can expect.

Plenary speakers

Wah Chiu

Wah Chiu
Stanford University and SLAC National Accelerator Laboratory

Ryan Kelly

Ryan Kelly
Brigham Young University

Dave Pagliarini

Dave Pagliarini
Washington University School of Medicine in St. Louis

Stuart Schreiber

Stuart Schreiber
Harvard University

Catherine Wu

Catherine Wu
Dana–Farber Cancer Institute

Speakers

  • Marcus Bantscheff, GlaxoSmithKline
  • Pierre-Jean Beltran, Broad Institute
  • Hannah Boekweg, Brigham Young University
  • Claudia Ctortecka, Broad Institute
  • Katherine Donovan, Harvard University
  • Michael Fainzilber, Weizmann Institute of Science
  • Nicole Gay, Stanford University
  • Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute
  • Lan Huang, University of California, Irvine
  • Trey Ideker, University of California, San Diego
  • Jeroen Krijgsveld, German Cancer Center
  • Matthias Mann, Max Planck Institute of Biochemistry
  • Ana Martinez Del Val, University of Copenhagen
  • Philipp Mertins, Max Delbrück Center for Molecular Medicine
  • Matthew Rasband, Baylor College of Medicine
  • Julio Saez–Rodriguez, University of Heidelberg
  • Yardena Samuels, Weizmann Institute of Science
  • Erwin Schoof, Danish Technical University
  • Devin Schweppe, University of Washington
  • Nikolai Slavov, Northeastern University
  • Alice Ting, Stanford University
  • Henning Urlaub, Max Planck Institute for Multidisciplinary Sciences
  • James Wells, University of California, San Francisco 
  • Forest White, Massachusetts Institute of Technology
  • Mathias Wilhelm, Technical University of Munich
  • Jana Zecha, AstraZeneca
  • Aleksej Zelezniak, Chalmers University of Technology
  • Bing Zhang, Baylor College of Medicine
  • Ying Zhu, Pacific Northwest National Laboratory

Sponsors

 
 

Sponsorship opportunities

The symposium will offer a variety of sponsorship opportunities for your organization to optimize their visibility to attendees. Learn about sponsorship opportunities

 

What’s included

The symposium package includes:

In-person registration:

  • All scientific sessions and meeting materials for both the minisymposium and the main symposium
  • Access to poster session
  • Networking refreshment breaks

Virtual registration:

  • Access to session talks only

Presentation requirements

All speakers and poster presenters are required to present in person at the scheduled date and time of their session.

Registration changes

Registration changes (including changing registration type from virtual to in-person) will be accepted as space allows until July 1, and can be made by contacting meetings@asbmb.org or calling the ASBMB accounting department at 240-283-6600.

Cancellation policy

Cancellations received in writing on or before July 1 are subject to a $100 processing fee. No refunds will be issued for cancellations after July 1, due to final guarantee commitments. To cancel, email meetings@asbmb.org and attach a copy of your meeting registration receipt/paid invoice.

COVID-19 vaccine requirement

For the health and safety of attendees, ASBMB/Mass spectrometry in the health and life sciences is requiring COVID-19 vaccines for anyone attending this symposium. Mask wearing and other requirements will be taken into consideration based on state and local guidelines and will be communicated with attendees before the start of the event.

Access the latest COVID-19 guidelines from:

Hotel accommodation

Boston Marriott Cambridge
50 Broadway
Cambridge, MA 02142

Instructions on reserving hotel accommodation will be provided during the symposium registration process.

Program schedule

All sessions and activities will be held at the Broad Institute of MIT and Harvard, unless noted otherwise.

Sunday August 14
Monday August 15
Tuesday August 16
Wednesday August 17
Thursday August 18

Sunday agenda

8:00 AM - 7:00 PM
Auditorium

Minisymposium on advances in single cell proteomics

Organizers

  • A.L. Burlingame, University of California, San Francisco
  • Steven Carr, Broad Institute of MIT and Harvard
  • Bernhard Küster, Technical University of Munich
8:15 AM - 8:30 AM
Auditorium

Opening remarks

A.L. Burlingame, Steven Carr, and Bernhard Küster

8:30 AM - 9:00 AM
Auditorium

Plenary session

Chair: Steven Carr, Broad Institute of MIT and Harvard

Increasing the coverage, throughput and accessibility of single-cell proteomics
Ryan Kelly, Brigham Young University
9:00 AM - 11:50 AM
Auditorium

Morning session

Chair:  Steven Carr, Broad Institute of MIT and Harvard

Innovations in single-cell proteomics enable exploring functional protein covariation across thousands of single cells
Nikolai Slavov, Northeastern University
Three-dimensional feature matching improves the sensitivity of single-cell and spatial proteomics
Ying Zhu, Pacific Northwest National Laboratory
A high-throughput sample preparation approach for label-free and multiplexed single-cell proteomics
Claudia Ctortecka, Broad Institute of MIT and Harvard
1:30 PM - 4:10 PM
Auditorium

Afternoon session

Chair:  Jeroen Krijgsveld, German Cancer Research Center

Leveraging advanced latest-generation data acquisition and MS instrument architecture for improving single cell proteomics experiments
Erwin Schoof, Danish Technical University
Ultra-high sensitivity proteomics for precision oncology
Matthias Mann, Max Planck Institute of Biochemistry
Selected short talk: Computational challenges of identification and quantification algorithms in single-cell proteomic data
Hannah Boekweg, Brigham Young University
Intelligent data acquisition approaches for single cell proteomics
Tommy Cheung, Genentech
A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics
Yi-Ting Wang, Pacific Northwest National Laboratory (PNNL)
Toward comprehensive, single-molecule proteomics
Parag Mallick, Stanford University
4:30 PM - 7:00 PM
Yellowstone & Monadnock Rooms

Poster session A

7:00 PM - 9:00 PM
Lobby

Opening reception

Monday agenda

8:15 AM - 8:30 AM
Auditorium

Opening remarks

A.L. Burlingame, Steven Carr, and Bernhard Küster

8:30 AM - 9:30 AM
Auditorium

Plenary session

Chair: Jana Zecha, AstraZeneca

Defining mitochondrial protein functions through deep multi-omic profiling
David Pagliarini, Washington University School of Medicine in St. Louis
9:30 AM - 12:30 PM
Auditorium

Morning session

Chair: Jana Zecha, AstraZeneca

Navigating proteomics techniques for molecular profiling of clinical cancer cohorts
Philipp Mertins, Max-Delbrück-Center for Molecular Medicine
Characterizing proteome regulation and cell signaling by nascent proteomics: an aha-experience
Jeroen Krijgsveld, German Cancer Research Center
From AI-driven synthetic biology to prediction of molecular phenotypes
Aleksej Zelezniak, Chalmers University of Technology
Mapping diverse proteome responses with intelligent mass spectrometry
Devin Schweppe, University of Washington
2:00 PM - 3:40 PM
Auditorium

Afternoon session

Chair: Philipp Mertins, Max-Delbrück-Center for Molecular Medicine

Prosit boosts mass spectrometry-based proteomics one spectrum at a time
Mathias Wilhelm, Technical University of Munich
Spatial proteomics via enzyme-catalyzed proximity labeling
Alice Ting, Stanford University
An AI-driven leap forward in peptide identification through deconvolution of chimeric spectra 
Martin Frejno, MSAID GmbH
3:40 PM - 7:00 PM
Yellowstone & Monadnock Rooms

Poster session A

Tuesday agenda

8:30 AM - 9:30 AM
Auditorium

Plenary session

Chair: Jim Wells, University of California, San Francisco
 
The rise of molecular glues and bifunctional compounds
Stuart Schreiber, Broad Institute of MIT and Harvard
9:30 AM - 12:35 PM
Auditorium

Morning session

Chair: Bernhard Küster, Technical University of Munich

Mapping the degradable kinome: A resource for expedited degrader development
Katherine Donovan, Harvard University
Tracking drug action at the cell surface and the secreted proteome
Marcus Bantscheff, Glaxo Smith Kline
Unravelling RNA– and DNA–protein interactions with mass spectrometry
Henning Urlaub, Max Planck Institute for Multidisciplinary Sciences
Developing cross-linking mass spectrometry to define protein interaction landscapes
Lan Huang, University of California, Irvine
2:00 PM - 4:00 PM
Auditorium

Afternoon session

Chair: Lan Huang, University of California, Irvine

An accurate large-scale human E3 ligase concentration map for next-generation TPD-based precision medicine created by MaxQuantAtlas
Kirti Sharma, Kymera Therapeutics
Discovery of GSTZ1 as a novel target by using fully functionalized fragment-like probes and chemical proteomics
Yi Liao, H. Lee Moffitt Cancer Center & Research Institute
High-throughput subcellular proteomics reveals phospho-signaling dynamics
Ana Martinez Del Val, University of Copenhagen
DecryptM: Decrypting pathway engagement and mechanisms of action of cancer drugs by dose-resolved proteomics profiling of post-translational modifications
Jana Zecha, AstraZeneca
4:20 PM - 6:15 PM
Yellowstone & Monadnock Rooms

Poster session B

Wednesday agenda

8:30 AM - 9:30 AM
Auditorium

Plenary session

Chair:  A.L. Burlingame, University of California, San Francisco

Integrative structural biology to understand biological complexity
Wah Chiu, Stanford University and SLAC National Accelerator Laboratory
9:30 AM - 12:30 PM
Auditorium

Morning session

Chair: Namrata Udeshi, Broad Institute of MIT and Harvard

In situ cell-surface proteomics: Method development and applications in neurobiology
Jiefu Li, Janelia Research Campus, HHMI
Pirating biology to probe and attack the surfacome in cancer
Jim Wells, University of California, San Francisco
Multiplexed proximity biotinylation to uncover the axon initial segment proteome
Matthew Rasband, Baylor College of Medicine
Logistics over long distances: Nascent proteomes in nerve axons
Michael Fainzilber, Weizmann Institute of Science
2:00 PM - 3:40 PM
Auditorium

Afternoon session

Chair: Michael Fainzilber, Weizmann Institute of Science

Temporal dynamics of the multi-omic response to endurance exercise training across tissues
Nicole Gay, Stanford University
Pierre-Jean Beltran, Broad Institute of MIT and Harvard
Chemoproteomic capture of RNA binding activity in living cells
Andrew Heindel, University of Virginia
Isobaric labeling mass spectrometry to monitor ubiquitination dynamics upon proteasome modulation by small molecule inhibitors 
Jeroen Demmers, Erasmus University Medical Center
3:40 PM - 6:00 PM
Yellowstone & Monadnock Rooms

Poster session B

7:00 PM - 9:00 PM

Conference reception at the Isabella Stewart Gardner Museum

Advance ticket purchase required, transportation provided.

Thursday agenda

8:30 AM - 9:30 AM
Auditorium

Plenary session

Chair: Jenn Abelin, Broad Institute of MIT and Harvard

Identification of tumor antigens for cancer immunotherapy
Catherine Wu, Dana Farber Cancer Institute
9:30 AM - 12:30 PM
Auditorium

Morning session

Chair: Michael Gillette, Broad Institute of MIT and Harvard & Massachusetts General Hospital

Deciphering the highly complex cancer immunopeptidome
Yardena Samuels, Weizmann Institute of Science
Translating cancer proteogenomics data into biological and clinical insights
Bing Zhang, Baylor College of Medicine
Clinical phosphoproteomics to uncover new therapeutic strategies
Forest White, Massachusetts Institute of Technology
Chemoproteomic identification of functional microproteins
Sarah Slavoff, Yale University
Finding cancer pathways through changes in mRNA/protein relationships 
Jose H. Giraldez Chavez, Brigham Young University
2:20 PM - 4:20 PM
Auditorium

Afternoon session

Chair: Natalie Clark, Broad Institute of MIT and Harvard

Proteogenomic analysis of multiple myeloma reveals therapeutic opportunities and predictive signatures 
Evelyn Ramberger, Charité Universitätsmedizin
Combining proteomics (and other omics) and biological knowledge to extract disease mechanisms
Julio Saez–Rodriguez, University of Heidelberg
Building a mind for cancer
Trey Ideker, University of California, San Diego
4:20 PM - 4:45 PM
Auditorium

Closing remarks and discussion

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