June 21 | Virtual

Flux-independent signaling by ionotropic receptors

Unforeseen roles and complexities

Flux-independent signaling by ionotropic receptors: Unforeseen roles and complexities
June 21, 2021 | Virtual

Traditionally, ionotropic receptors (or channels) have been studied from the elctrophysiological point of view, because they mediate the pass of ions from one side of a biological membrane to the other, thus modulating the plasma membrane potential and therefore cell function. This feature among others gave birth in the 1970s to the categorization into ionotropic and metabotropic receptors. However, several findings in the last 20 years have evidenced that ionotropic receptors are also able to signal intracellularly independently of channel opening and ion flux. Moreover, these new described functions have helped to understand conundrums of the physiology of different cells in the nervous system, and this could be extensive to other somatic cells as these receptors are ubiquitous in cells and tissues.

One of the most studied group of receptors in this context is the glutamate ionotropic receptors, that include the Kainate, AMPA and NMDA receptors. Nevertheless, there is also evidence for nicotinic Ach receptors, Kv channels, Voltage gated Ca2+ Channels. These findings have opened a new horizon to study from the molecular, biochemical and cellular perspective ionotropic receptors in “non-electrically excitable cells” in which these channels are expressed, but their function is not understood or has been studied only slightly.

This event will be of interest to neuroscientists, cell biologists, molecular biologists and biochemists among others involved in the study of cell physiology and function in health and disease.


Pavel Montes de Oca Balderas
Pavel Montes de Oca Balderas
Instituto de Fisiologia Celular — UNAM/Instituto Nacional de Neurologia y Neurocirugia — SSA


Robert Bonin, University of Toronto

Metabotropic NMDA receptor signaling and synaptic depression
Kim Dore, University of California, San Diego

Inhibition of ATP signaling in human monocytes by canonical and noncanonical nicotinic agonists
Veronika Grau, Justus Liebig University Giessen

Canonical and non-canonical signalling of ionotropic glutamate receptors: The case of Kainate receptors
Juan Lerma, Instituto de Neurociencias de Alicante

Flux-independent signaling by NMDAR in astrocytes and plasma membrane-mitochondria bridges
Pavel Montes de Oca Balderas, Instituto de Fisiologia Celular — UNAM/Instituto Nacional de Neurologia y Neurocirugia — SSA

A role for Kv1.3 channels as voltage sensors to induce proliferation in an ion-flux independent way
Maria Teresa Perez Garcia, Universidad de Valladolid

Michael Salter, Hospital for Sick Children

Differential regulation of evoked and spontaneous release by presynaptic NMDA receptors
Jesper Sjostrom, McGill University

Endogenous regulation of non-ionotropic NMDA receptor excitotoxicity
Roger J. Thompson, Mathison Centre for Mental Health Research & Education

Karen Zito, University of California, Davis

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