• Serine Proteases in Pericellular Proteolysis and Signaling

    September 12–15, 2019, Potomac, Md.

Serine Proteases in Pericellular Proteolysis and Signaling

Organized by: Eric Camerer, INSERM; Bob Lazarus, Genentech, Inc.

Meeting Description

The 2019 symposium on Serine Proteases in Pericellular Proteolysis and Signaling continues the tradition of the special symposia on membrane-anchored serine proteases with an expanded focus on other serine proteases with overlapping substrates and functions in the pericellular environment.

Proteases account for approximately 2% of mammalian proteome. A subset of these in the serine protease superfamily are actively involved in coordinating organ development and cellular behavior through proteolytic processing of hormones, growth factors, membrane receptors and ion channels. While some, such as the membrane-anchored serine proteases (MASPs), contain transmembrane domains or lipid anchors, others make use of plasma membrane cofactors and other mechanisms to direct their activities to the pericellular environment. Pericellular proteolysis is important for organ development and homeostasis but can also contribute to epithelial and endothelial barrier dysfunction, inflammatory disease, cancer, cardiovascular disease and neurodegenerative diseases if protease activities are not adequately restrained. Understanding the biochemistry and biology of these proteases and their regulators is therefore of great interest to basic science, clinical research and drug development.

We plan to have five sessions that will cover topics including physiological, pathological and developmental aspects of pericellular proteolysis, regulation of protease activities, protease signaling, structural biology and protease engineering and methods for detection and imaging of protease activities. 

We encourage all members of the serine protease community, from both academia and industry, to attend the meeting. We will have a substantial number of talks selected from abstracts, a poster session, poster and speaker prizes (for early career scientists) to engage all meeting participants. The meeting will be informal to encourage interactions between early career and experienced scientists at meeting and poster sessions, meals, activities and receptions.

Important Dates — Deadlines Extended

July 26: Deadline to submit abstract for short talk consideration 
July 26: Save $100 — Early registration deadline
August 15: Poster abstract submission deadline 
August 15: Symposium registration deadline 
August 1: Registration cancellation deadline