Program

The 2020 ASBMB Annual Meeting will feature sessions organized into the following tracks:

  • Biochemistry of lipids and membranes
    Organized by Steve Claypool, Johns Hopkins School of Medicine, and Teresa Dunn–Giroux, Uniformed Services University of the Health Sciences
  • Glycosylation and extracellular matrix in development, repair and disease
    Organized by Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute, and Joanne Murphy–Ullrich, University of Alabama Medical Center
  • Molecular machines — structure and function
    Organized by Nathan Alder, University of Connecticut, and Jochen Zimmer, University of Virginia
  • Molecular mechanisms of cell signaling
    Organized by Wendy Gordon, University of Minnesota, and Adrian Salic, Harvard University
  • New developments in metabolism
    Organized by Marcia Haigis, Harvard University, and Anne Murphy, University of California, San Diego
  • RNA and disease
    Organized by Takahiro Ito, University of Georgia, and Anita Hopper, Ohio State University
  • Re-imagining STEM: Who we are and what we do
    Organized by Daniel Dries, Juniata College, and Nathan Vanderford, University of Kentucky
  • Understanding the rules of life
    Organized by Suzanne Barbour, University of Georgia

Click on a session title to view details.

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Saturday, April 4
6–7 p.m. Tang Prize award lecture
Tyrosine phosphorylation — From discovery to drug development and beyond
Tony Hunter, Salk Institute for Biological Studies
 
Sunday, April 5
8–8:15 a.m. ASBMB business meeting  
8:15–9:15 a.m. Herbert Tabor Research Award lecture
Structural basis of dystroglycan function and the pathogenesis of muscular dystrophy
Kevin Campbell, University of Iowa
 
ASBMB–Merck Award lecture
Cellular machineries devoted to rubisco — the most abundant enzyme
Manajit Hayer-Hartl, Max Planck Institute of Biochemistry
 
9:30–11:30 a.m.
Novel roles of lipids in health and disease

Chair: Steven Claypool, Johns Hopkins School of Medicine

  • Seipin in lipid mobilization and lipodystrophy
    Weiqin Chen, Medical College of Georgia at Augusta University
  • The role of organelle contact during chlamydia developmental cycle
    Isabelle Derré, University of Virginia
  • Cardiolipin exerts tissue-specific control over systemic energy homeostasis
    Zachary Gerhart-Hines, University of Copenhagen
  • SPTLC1 mutations associated with early onset amyotrophic lateral sclerosis
    Teresa Dunn, Uniformed Services University
 
Glycosylation and extracellular matrix in development, repair and cancer
  • TGF-beta regulation by the matricellular protein thrombospondin 1
    Joanne Murphy-Ullrich, University of Alabama at Birmingham, Chair  
  • Role of O-linked fucose-glucose disaccharide modification of thrombospondin type I repeats during protein folding and embryo development
    Bernadette Holdener, Stony Brook University
  • Fibrillin-notch interactions in development and disease
    Lynn Sakai, Oregon Health and Science University
  • A genetic approach to glycomics in cancer
    Henrik Clausen, University of Copenhagen
 
Molecular machines: New paradigms in structure, function, and engineering
  • Activation of the exocyst tethering complex for SNARE complex regulation and membrane fusion
    Mary Munson, University of Massachusetts Medical School
  • Sugary coats: Synthesis and secretion of extracellular polysaccharides
    Jochen Zimmer, University of Virginia School of Medicine
  • Molecular assemblies of membrane remodeling and scission
    James Hurley, University of California, Berkeley
  • HiFi molecular transmission via crisscross cooperativity
    William Shih, Harvard University
 
Mechanosignaling
  • Piezo1 activation gains traction
    Medha Pathak, University of California, Irvine
  • Mechanotransduction in vascular health and disease
    Martin Schwartz, Yale University
  • Mechanical force and notch signaling
    Wendy Gordon, University of Minnesota, Chair
  • Mechanisms linking mechanotransduction and cell metabolism
    Kris DeMali, University of Iowa
 
NAD synthesis, salvage and sirtuins in tissue health
  • Modulating de novo NAD synthesis
    Johan Auwerx, Ecole Polytechnique Fédérale de Lausanne
  • NAD homeostasis and compartmentation
    Joseph A. Baur, University of Pennsylvania
  • Chromatin regulation and genome maintenance by mammalian SIRT6 and SIRT7
    Katrin F. Chua, Stanford University and VA Palo Alto Health Care System
  • Metabolic competition in the tumor microenvironment
    Marcia Haigis, Harvard Medical School
 
Noncoding RNAs and disease
  • tRNA: Splicing and subcellular dynamics
    Anita Hopper, Ohio State University, Chair
  • The role of 3’tsRNAs in gene regulation
    Mark Kay, Stanford University
  • The Piwi-piRNA pathway: A new paradigm in gene regulation
    Haifan Lin, Yale University
  • piRNA biogenesis and function in drosophila
    Mikiko Siomi, University of Tokyo
 
Who we are: Creating a culture of wellness in science

Chair: Daniel Dries, Juniata College

  • Preventing and overcoming harassment
    Alex Helman, National Academies of Sciences, Engineering and Medicine
  • Promoting STEM identity: A vision for building tomorrow’s STEM leaders
    Sarah Rodriguez, Texas A&M University - Commerce
  • Promoting mental wellbeing
    Nathan Vanderford, University of Kentucky
  • Mentorship best practices
    Joanne Kamens, Addgene
 
Cell decision making
  • Longitudinal analysis of genetic networks as determinants of lifespan in C. elegans
    Adriana San Miguel, North Carolina State University
  • Mechanical principles of nuclear shaping and positioning
    Tanmay Lele, University of Florida, Chair
  • Clocks, hourglasses and history-dependent clocks
    Arvind Murugan, University of Chicago
 
11:45 a.m. – 12:45 p.m. Meet the speakers
12:15–1:45 p.m.
ASBMB advocacy town hall meeting

Increasingly, policies developed and enacted in Washington are having an impact on how your science is funded, how your grants are reviewed and how reliable the future workforce of the research community will be. Serving the ASBMB membership proudly, the Public Affairs Advisory Committee and Office of Public Affairs regularly engages on your behalf with the Administration, the Congress and the individual funding agencies.

This Advocacy Town Hall is an opportunity to share your stories, and to tell the PAAC what policy areas you want to see the ASBMB taking a leadership role in. Hosted by Public Affairs Director Benjamin Corb, and PAAC Chair Terri Kinzy, the Advocacy Town Hall will allow you to engage in a conversation with our policy leaders, to hear about the critical policy issues facing the community, and ask questions.

12:45–2 p.m. Poster sessions
1:30–3 p.m.
Changing research practice: How can I make my research more reproducible?

Co-sponsored by the American Physiological Society

This session will focus on concrete steps that biomedical researchers can take to implement more reproducible research practices in their laboratories. These include using RRIDs to identify key reagents, creating and sharing reproducible protocols that can be used by others, and using guidelines to enhance experimental rigor and improve reporting. Attendees will learn to recognize and fix common errors in data visualization and statistical reporting. Presenters will highlight tools and resources designed to assist researchers in implementing better practices. After attending the symposium, researchers should have a clear understanding of steps that they can immediately take to improve transparency and rigor in their next grant, research project, or paper.

2:15–3:15 p.m. Earl and Thressa Stadtman Young Scholar Award lecture
Wiring the powerhouse: Systems-to-structure approaches for defining mitochondrial protein function
David Pagliarini, Morgridge Institute for Research
 
Avanti Award in Lipids lecture
Death by lipids: Role of non-coding RNAs in metabolic stress
Jean Schaffer, Joslin Diabetes Center at Harvard University
 
3–5 p.m.
Proliferation and protection: Harnessing the beta-cell for novel diabetes therapies
Organized by the Society for Experimental Biology and Medicine (SEBM)
Chair: Rachel Fenske, University of Wisconsin-Madison
  • Dawn B. Davis, University of Wisconsin
  • Anath Shalev, University of Alabama–Birmingham
  • Debbie Thurmond, Beckman Research Institute of City of Hope
 
3:30–5:30 p.m. Regulation of protein function by shape shifting
Delano Award for Computational Biosciences lecture
Towards the solution of the protein structure prediction problem
Yang Zhang, University of Michigan
 
3:30–4:30 p.m. Award for Exemplary Contributions to Education lecture
A revolution in biochemistry education informed by basic research to meet the demands of 21st century career paths
Paul Black, University of Nebraska–Lincoln
 
JBC Herbert Tabor Early Career Investigator Award: Journal of Biological Chemistry honors first authors
3:30–4:30 p.m. Spotlight sessions
4:45–5:45 p.m. Spotlight sessions
6–7:30 p.m.
Workshop: Mentoring from both sides: How to find, be and utilize a great mentor
Mentoring should not be a scary or imposing concept — it's really just about getting and giving advice, support and encouragement for ongoing learning. This workshop is intended for everyone: trainees and faculty ready to learn practical tactics in identifying mentors, making the "ask" for mentoring support and how to take the best advantage of mentoring relationships — from both sides.
Workshop: Storytelling and the art of giving a great presentation
Workshop: Organizing a successful ASBMB Student Chapter
Workshop: Emerging technologies in the glycosciences
5:30–9 p.m. Social and networking events
Monday, April 6
8–9 a.m. William C. Rose Award lecture
Constraining evolution → avoiding drug resistance: Lessons from viruses
Celia Schiffer, University of Massachusetts Medical School
 
Mildred Cohn Award in Biological Chemistry lecture
Toolbox to evaluate biological function of histone deacetylases
Carol Fierke, Texas A&M University
 
9–11 a.m.
Antibiotic resistance: How to beat the bugs
Organized by the Society for Experimental Biology and Medicine (SEBM)
Co-Chairs: Peter Stambrook, University of Cincinnati Cancer Institute, and Warren Zimmer, Texas A&M College of Medicine
  • Jason Gill, Texas A&M University
  • Kim Lewis, Northeastern University
  • Rebekah Dedrick, University of Pittsburgh
 
9:15–11:15 a.m.
How lipids impact the structure and function of membrane proteins
  • Membrane proteins — the lipid connection
    Carol Robinson, University of Oxford
  • Structural basis of lipid scrambling and ion conduction by TMEM16 scramblases
    Alessio Accardi, Weill Cornell Medical College
  • Structural insights into TRPV channel gating
    Vera Moiseenkova-Bell, University of Pennsylvania
  • Cardiolipin-dependent carriers
    Steven Claypool, Johns Hopkins School of Medicine
 
Glycosylation and extracellular matrix in immunologic, inflammatory and infectious disease
  • Decoding inflammatory signals from ecm glycans for the development of new immunotherapies
    Kim S. Midwood, University of Oxford, Chair
  • Glycosylation in a common mechanism of colitis and sepsis
    Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute
  • Genome wide analysis of heparan sulfate assembly
    Jeffrey D. Esko, University of California, San Diego
  • PAMPs, DAMPs and SAMPs. Host glycans are self-associated molecular patterns, but subject to microbial molecular mimicry
    Ajit Varki, University of California, San Diego
 
Post-translational modifications/signaling
  • Getting hedgehogs where they need to go
    Stacey Ogden, St. Jude Children’s Research Hospital
  • Rhomboid proteins in cell signaling
    Matthew Freeman, University of Oxford
  • Lipids and hedgehogs
    Adrian Salic, Harvard University Medical School, Chair  
  • Role of notch glycoslation in signaling
    Pamela Stanley, Albert Einstein College of Medicine
 
Control of cell fate by metabolic intermediates
  • Microbiome catabolites as novel modulators of cellular glucose and energy metabolism
    Gary Williamson, Monash University
  • Metabolic modulation of cardiac health: The role of glucose and amino acids
    Rong Tian, University of Washington
  • Control of macrophage activation by coenzyme A
    Ajit Divakaruni, University of California, Los Angeles
  • A quantitative tissue-specific landscape of protein redox regulation during aging
    Edward Chouchani, Harvard University
 
Molecular motors

Chair: Nathan Adler, University of Connecticut

  • Integrated 3D tomography and computational modeling to study forces in metaphase spindles
    Stefanie Redemann, University of Virginia School of Medicine
  • Single molecule biophysics
    Carlos Bustamante, University of California, Berkeley
  • Myosin: Structure, function, regulation and disease
    Michelle Peckham, University of Leeds
  • Watching a fine-tuned molecular machine at work: Structural and functional studies of the 26S proteasome
    Andreas Martin, University of California, Berkeley
 
RNA modifications and disease
  • RNA modification in cancer
    Jianjun Chen, Beckman Research Institute of City of Hope
  • RNA modifications in health and disease
    Tsutomu Suzuki, University of Tokyo
  • Acetylation of cytidine in messenger RNA regulates translation
    Shalini Oberdoerffer, National Cancer Institute
  • tRNA quality control: Mechanisms, evolution and implications for human disease
    Eric Phizicky, University of Rochester Medical Center, Chair
 
Regulation of gene expression
  • Computational approaches to predicting transcription factor binding kinetics
    Polly Fordyce, Stanford University, Chair
  • Synthetic NF-kB: A building approach to study complex signaling behaviors
    Ping Wei, Peking University Center for Quantitative Biology
 
What we do: Choosing pedagogy over content

Chair: Nathan Vanderford, University of Kentucky

  • Grand challenges: building interdisciplinary communities to tackle complex global issues
    Jodi Schwarz, Vassar College
  • Teaching biochemistry in context
    Daniel Dries, Juniata College
  • Using narrative in STEM education
    Reneta Lansiquot, New York City College of Technology
  • Restructuring the classroom to promote student thriving, not just surviving
    Shannon Z. Jones, University of Richmond
 
11:30 a.m. – 12:30 p.m. Meet the speakers
12:30–1:45 p.m. Poster sessions
1–3 p.m.
Role of R-loop formation in human disease
Organized by the Society for Experimental Biology and Medicine (SEBM)
Chair: Edward Motea, Indiana University Simon Comprehensive Cancer Center
  • James Manley, Columbia University
  • Julio C. Morales, University of Oklahoma Health Sciences Center
 
2–3 p.m. Ruth Krischstein Diversity in Science Award lecture
Getting there: Thyroid hormone receptor intracellular trafficking
Lizabeth Allison, William & Mary
 
Walter A. Shaw Young Investigator Award in Lipid Research lecture
Chemical tools that IMPACT phospholipid signaling
Jeremy Baskin, Cornell University
 
3–5 p.m.
Synthetic biology
Organized by the Society for Experimental Biology and Medicine (SEBM)
Chair: Peter Stambrook, University of Cincinnati Cancer Institute
  • Floyd Romesberg, Synthorx
  • Hana El-Samad, University of California, San Francisco
  • Neal Devaraj, University of California, San Diego
 
3:15–4:15 p.m. Exciting biological insights revealed by proteomics: a Molecular & Cellular Proteomics presentation
Education and Professional Development Committee session
3:15–4:15 p.m. Spotlight sessions
3:15–5 p.m. Alice and C.C. Wang Award in Molecular Parasitology symposium
Host parasite interactions between the sexually-transmitted parasite trichomonas vaginalis and its human host
Patricia Johnson, University of California, Los Angeles
 
3:15–5:30 p.m. Enzyme regulation by filamentation and other alternate and emerging mechanisms
4:30–5:30 p.m. Spotlight sessions
5:45–7:15 p.m. Workshop: Education and professional development
Workshop: Transforming science research into outreach
Workshop: Engaging the next generation of biochemistry students: Using 3D-printed models to teach structure-function relationships and network models and simulations to teach metabolic systems in biochemistry courses

Rebecca Roston, Tomas Helikar and Christine Booth, University of Nebraska–Lincoln
Michelle Howell, LCC International University

This workshop takes participants through a comprehensive suite of modules demonstrated to improve educational outcomes in two core undergraduate biochemistry concepts. The first module helps students build accurate mental models of 3D macromolecular structures from 2D images. The second targets how metabolism works not only in discrete modules (e.g., glycolysis, citric acid cycle, electron transport chain) but also as part of larger and dynamic interconnected systems within cells and organisms. Participants will each receive a 3D-printed macromolecule model set and a set of printable coordinates for additional model sets. Additionally, participants will also receive training in software designed for using modeling and simulations to teach about metabolism and other complex biological systems. Finally, instructor materials (associated slides and assessments) will be provided to make classroom incorporation as easy as possible. We will also share strategies and techniques on how to assess student perceptions and modify incorporation for optimal student engagement. Food will be provided.

5:30–9 p.m. Social and networking events

 

Tuesday, April 7
8:30–9 a.m. Bert and Natalie Vallee Award in Biomedical Science lecture
Enzyme hydrophobic sites and allosteric membrane interactions regulate signaling and mediators of inflammation
Edward Dennis, University of California, San Diego
 
9–11 a.m.
Intracellular trafficking
Organized by the Society for Experimental Biology and Medicine (SEBM)
Chair: Vinita Takiar, University of Cincinnati
  • Sima Lev, Weizmann Institute
  • Ora Weisz, University of Pittsburgh
  • Michael Caplan, Yale University
 
9:15–11:15 a.m.
Membrane biogenesis and trafficking

Chair: Teresa Dunn-Giroux, Uniformed Services University

  • Lipid droplet proteome dynamics and lipotoxicity
    James Olzmann, University of California, Berkeley
  • Mechanistic approaches towards understanding physicochemical membrane homeostasis in the endoplasmic reticulum
    Robert Ernst, Saarland University
  • The role of VPS13 and related proteins in glycerolipid transport at membrane contact sites
    Karin Reinisch, Yale University School of Medicine
  • Cold-induced lipid dynamics in thermogenic fat
    Yu-Hua Tseng, Harvard University Medical School
 
Glycosylation and extracellular matrix in neurologic and metabolic diseases

Chair: Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute

  • Protective roles of O-GlcNAc in neurodegenerative diseases
    David Vocadlo, Simon Fraser University
  • The role of the O-GlcNAc transferase interactome in X-linked intellectual disability
    Lance Wells, University of Georgia Complex Carbohydrate Research Center
  • Role of ECM in the brain-gut connection
    Fernando Gomez-Pinilla, University of California, Los Angeles Brain Injury Research Center
  • The role of metabolism in modulating radiation fibrosis
    Fei-Fei Liu, Princess Margaret Cancer Centre, Toronto
 
Emerging mechanisms of signaling

Chairs: Wendy Gordon and Adrian Salic

  • Ligand engineering for probing receptor signaling mechanisms
    Chris Garcia, Stanford University
  • Cellular communication via adhesion
    Demet Arac, University of Chicago
  • Mechanisms of Wnt5a-Ror signaling in development and disease
    Henry Ho, University of California, Davis
  • Wnt/Planar cell polarity signaling in skeletal development
    Yingzi Yang, Harvard University Dental School
 
New insights into control of metabolism by transporters
  • Glutamine transporter as a target of mTOR signaling modulating longevity
    John M. Sedivy, Brown University
  • Neuroprotection through control of mitochondrial pyruvate transport
    Anne Murphy, Cytokinetics, Inc.
  • Local and systemic actions of hepatic fatty acid oxidation
    Michael Wolfgang, Johns Hopkins University School of Medicine.
  • Physiopathological roles of the mitochondrial calcium uniporter
    Anna Raffaello, University of Padova
 
Molecular motors in transport, biosynthesis and energy transduction

Chair: Jochen Zimmer, University of Virginia

  • Functional assembly of the mitochondrial protein transport machinery
    Nathan Alder, University of Connecticut
  • Structure of the alternative complex III from flavobacterium johnsoniae in a supercomplex with cytochrome c oxidase
    Robert Gennis, University of Illinois
  • Special capabilities of the ribosomal machinery
    Roland Beckmann, Ludwig Maximilian University of Munich
  • Nascent protein selection and triage at the ribosome exit site
    Shu-ou Shan, California Institute of Technology
 
RNA binding proteins and control of RNA biogenesis in disease
  • RNA binding proteins in stem cells and cancer
    Takahiro Ito, University of Georgia, Chair
  • The RNA exosome and genetic disease
    Anita Corbett, Emory University
  • RNA, chromatin and the coordinated control of gene expression
    Tracy Johnson, University of California, Los Angeles
  • How mRNP composition determines mRNA fate
    Guramrit Singh, Ohio State University
 
Best practices for preventing/managing incidences of harassment in the workplace
11:30 a.m. – 12:30 p.m. Meet the speakers
12:30–1:45 p.m. Poster sessions
2–3 p.m.
Lipid Diversity and Disease: Spotlight on Journal of Lipid Research Junior Associate Editors
  • Raymond Blind, Vanderbilt University Medical Center
  • Rotonya Carr, University of Pennsylvania
  • Brandon Davies, University of Iowa
  • Gissette Soffer, Columbia University
 
2–3 p.m. Spotlight sessions
3–4 p.m. Spotlight sessions