Tabor award
for bacterial colony work

Why can a bacterium usually found in the mouth also drive an infection linked to heart failure? How does a nascent bacterial colony in the heart protect itself from being swept away? Catherine Back won a 2018 Journal of Biological Chemistry/Herbert Tabor Young Investigator Award for her work on the mechanism of adhesion between a bacterial fibril protein and human tissues.

Catherine Back found a novel mechanism for streptococcal adhesion to fibronectin. Courtesy of Catherine Back

The protein, which she characterized while she was a postdoctoral fellow at the University of Bristol, helps the oral bacterial species Streptococcus gordonii attach to and colonize human tissues and may contribute to bacterial infection of the heart.

Back’s first research experience was as an undergraduate at Bristol, where she worked with microbiologist Howard Jenkinson on an interaction between S. gordonii and another species of commensal oral bacteria. She stayed on at Bristol for her Ph.D., extending her undergraduate studies with a closer and more multidisciplinary look at CshA, an adhesion protein.

“I thought it was really interesting to work on a protein that not much was known about,” she said.

While Jenkinson remained her primary supervisor, for her project, Back drew on the expertise of three principal investigators from two departments. Jenkinson and Angela Nobbs were frequent collaborators on microbiology research in the dental school, while biochemist Paul Race contributed expertise in protein characterization.

“I managed to work in both departments, learning microbiology and also structural biology,” Back explained. The collaboration between the groups continues to this day. The labs now work together to characterize other bacterial adhesins.

After earning her Ph.D., Back stayed on in Bristol to finish the work described in her JBC article and then moved to the nearby University of Bath to study a new type of vaccine for tuberculosis.

Back grew up in Exeter in Devon, England, and said she enjoys getting outdoors both in Bristol and on visits home. “I often go back to my parents’ house in Exeter,” she said. “It’s near the sea, and near Dartmoor, which is a really nice place to go hiking.”

Back recently returned to Bristol to join the lab of Paul Race for a new project, studying antimicrobials from bacteria that colonize deep-sea sponges.