Derailed But Undeterred

With a lot of help
from my friends

Christine Guthrie
By Christine Guthrie
May 1, 2013

I originally had no intention of ever becoming a principal investigator. I just wanted to do my science and be left alone. Besides, I had no idea how one could as a woman; certainly there were few role models. But my boyfriend had different ideas: The way he saw it, I should get a job and support us, preferably somewhere on the West Coast.

As things turned out, I received an offer to become an assistant professor in the biochemistry and biophysics department at the University of California at San Francisco. At the time, UCSF was a little-known school, commonly referred to as the Medical Center. (Indeed, until her death, my mother maintained that I was a professor at UC-Berkeley.)

I arrived in San Francisco in the late summer of 1973 a nervous wreck. The department consisted of six other faculty, all male. They were very friendly and supportive (if a bit bemused to have a female in their midst). It was the postdocs who scared me: The women were desperate to have a Role Model and made clear their high expectations of me to give them advice, yet all I could serve up was my own insecurity.

It was slow-going setting up my lab, I received a negative midcareer review, and tragedy struck when my trusted mentor, Gordon Tomkins, died prematurely. I fell into a deep, clinical depression and was hospitalized for six long weeks. Remarkably, when my colleagues came to visit me, they each said, “I know exactly how you feel; this is a really hard job.” This was the first I had heard — or ever imagined — that anyone else was also feeling challenged, and the validation had an enormous impact.

Through a lucky series of connections, I became involved with a group therapy program whose belief was that emotional support and problem-solving skills were key ingredients to survival in a competitive environment. With the encouragement of the professionals leading this program, a group of friends and colleagues from various walks of academia initiated a leaderless group, in which we met to exchange experiences and offer advice in dealing with our usually shared problems. Thanks to this group, I ultimately was able to be granted tenure and to build a strong and nurturing lab environment. Now, some 35 years later, we still meet regularly every other Thursday (as Ellen Daniell suggests in her book of that name), and I am happy to take this opportunity to spread the word about this empowering strategy and encourage you to consider it to enrich your own lives.

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Christine Guthrie
Christine Guthrie

Christine Guthrie is professor of biochemistry at the University of California, San Francisco and an American Cancer Society research professor of molecular genetics.

Related articles

Science interrupted
Stefan Lukianov
Entropy happens
Thomas E. Schindler
Just a kid from the farm
F. Peter Guengerich
My spouse and the mouse
Harvey J. Armbrecht

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in Opinions

Opinions highlights or most popular articles

A paleolithic peer review
Essay

A paleolithic peer review

April 18, 2024

You might think review panels have only been around for the last century or so. You would be mistaken.

Early COVID-19 research is riddled with poor methods and low-quality results
News

Early COVID-19 research is riddled with poor methods and low-quality results

April 13, 2024

The pandemic worsened, but didn’t create, this problem for science.

So, you went to a conference. Now what?
Professional Development

So, you went to a conference. Now what?

April 12, 2024

Once you return to normal lab life, how can you make use of everything you learned?

My guitar companion
Essay

My guitar companion

April 11, 2024

A scientist takes a musical journey through time and around the world.

Catalyzing change and redefining purpose
Essay

Catalyzing change and redefining purpose

March 28, 2024

To mark Women’s History Month, Sudha Sharma writes about her journey from focusing on her own research program to being part of a collaborative COVID-19 project.

The power of sabbaticals
Essay

The power of sabbaticals

March 28, 2024

To mark Women’s History Month, Nicholas Rhind writes about learning techniques in other researchers’ labs that empower the work in his own.