Theme organizers:
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Jeffrey Gorski
Univ. of
Missouri-Kansas City
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Karen Lyons
UCLA
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Interactions of Growth Factors and Integrins with the
Extracellular Matrix
Sunday, March 29, 2015, 9:45 AM - 12:00 PM • Room 257A/B
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9:45 Chair’s Introduction.
9:50 92.1 Integrins
Cooperate during Mechanosensing R. Fässler. Max Planck Inst. of
Biochem., Martinsried.
10:15 Trimeric G Protein Activation by the
Non-receptor Protein GIV/ Girdin Is Required for Integrin Signaling A.
Leyme, L. Perez-Gutierrez, L.T. Nguyen and M. Garcia-Marcos. Boston Univ. (719.5)
10:30 92.2 Members
of the CCN Family of Matricellular Proteins are Required for the Formation and
Maintenance of Multiple Skeletal Tissues K.M. Lyons. UCLA.
10:55 Endothelial Deficiency of the Extracellular
Matrix Protein CCN1 Alters Developmental and Pathological Angiogenesis B.
Chaqour, I. Krupska, L. Yan, L. Lau, M.B. Grant and H. Chintala. SUNY
Downstate Med. Ctr., Univ. of Illinois at Chicago and Indiana Univ. (719.2)
11:10 Extracellular Matrix Fibronectin Attenuates
PDGF-Induced Intracellular Calcium Release C.S. Farrar and D.C. Hocking. Univ.
of Rochester. (719.3)
11:25 92.3 Engineering
Interactions between Growth Factors and the Extracellular Matrix J.A.
Hubbell, M.M. Martino, P.S. Briquez, W.W. Kilarski, E. Guc and M.A. Swartz. Univ.
of Chicago and Swiss Fed. Inst. of Technol. Lausanne.
11:50 Discussion.
Effects of Enzymatic Modification of Extracellular Matrix
Proteins
Monday, March 30, 2015, 3:55 PM - 6:10 PM • Room 257A/B
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3:55 Chair’s Introduction.
4:00 236.1 Wnt
Modification by Tiki Proteins X. He. Boston Children’s Hosp. and Harvard
Med. Sch.
4:25 DC-SIGN Binds 2-Fucosyl-Lactose at
Concentrations Available in Human Milk R.D. Cummings, Y. Yu, Y. Lasanajak,
R. Buck, G. Duska-McEwen, P. Prieto and D.F. Smith. Emory Univ. Sch. of
Med. and Abbott Nutr., Columbus. (890.10)
4:40 236.2 The
Proprotein Convertases: Cell Surface and Extracellular Matrix Remodeling N.G.
Seidah, R. Essalmani, W. Kim, I. Welsh and N.A. Kurpios. IRCM, Clin. Res.
Inst. of Montreal and Cornell Univ.
5:05 Three-Dimensional Collagen IV and Hormone
Prolactin Regulate Breast Cancer Cell Invasion: Role of PAK1 and Matrix
Metalloproteinases M. Diakonova, P. Oladimeji and L. Rider. Univ. of
Toledo. (719.1)
5:20 Fibroblast-Macrophage Interactions:
Regulation by Modification of Extracellular Matrix A. Mazur, T. Kelly and
S.R. Post. Univ. of Arkansas for Med. Sci. (719.6)
5:35 236.3 MMPs as
Regulators of Tumor Microenvironment Z. Werb. UCSF.
6:00 Discussion.
Regulation of Stem Cell Niches by the Extracellular Matrix
Tuesday, March 31, 2015, 9:45 AM - 12:00 PM • Room 257A/B
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9:45 Chair’s Introduction.
9:50 359.1 ECM
Remodeling Events during EC-Pericyte Tube Co-assembly in 3D Matrices G.E.
Davis. Univ. of Missouri Sch. of Med.
10:15 Deletion of Integrin-Associated CD151 Impairs
Branching Morphogenesis and Activity of Progenitor Cells in the Mammary Gland X.
Yang and L.A. Baldwin. Univ. of Kentucky. (890.15)
10:30 359.2 Mesenchymal
Stem Cells: Diseases and Cure S. Shi. Univ. of Pennsylvania Sch. of
Dent. Med.
10:55 Investigating Laminin-α3β3γ2’s Potential Role in Epithelial-to-Mesenchymal
Transition in Pulmonary Epithelia J.A. David, B.A. Blakeney and R.L. Heise. Virginia
Commonwealth Univ. (719.17)
11:10 A Laminin 511 Matrix is Regulated by TAZ and Functions as the Ligand for the a6Bb1 Integrin to Sustain Breast Cancer Stem Cells A. Mercurio UMASS Med. Sch., Worcester, MA (890.4)
11:25 359.3 Proteolytic
Remodeling of the 3D Extracellular Matrix Controls the Nuclear Regulation of
Mesenchymal Stem Cell Fate and Function S.J. Weiss. Univ. of Michigan.
11:50 Discussion.
Function of the Extracellular Matrix in Development and
Disease
This session is jointly sponsored by ASBMB and AAA
Wednesday, April 1, 2015, 1:15 PM - 3:30 PM • Room 257A/B
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1:15 Chair’s Introduction.
1:20 495.1 Recessive
Forms of Osteogenesis Imperfecta and Implications for Mechanisms of Disease P.H.
Byers. Univ. of Washington.
1:45 Cargo Receptor Traffics Many Matrix Proteins
Out of the Endoplasmic Reticulum by Binding to N-Terminal IleProVal-Like Motif Y.
Yin, M.R. Garcia, A. Novak and L.W. Fisher. NIDCR, NIH. (719.12)
2:00 495.2 Crosstalk
between Bone and Muscle: Deletion of Mbtps1 in Bone Leads to Age-Dependent
Increase in Muscle Size and Contractile Function J.P. Gorski, N.T. Huffman,
N.G. Seidah, L. Bonewald and M. Brotto. Sch. of Dent., Univ. of
Missouri-Kansas City, Inst. of Res. Clins. of Montreal and Sch. of Nursing and
Hlth. Studies, Univ. of Missouri-Kansas City.
2:25 SUN2 Accumulation Contributes to Vascular
Smooth Muscle Cell Alterations Induced by Matrix Rigidity N. Bélaadi, G.
Chadeuf, L. Nguyen, M. Rio, G. Louarn, G. Loirand and C. Guilluy. INSERM,
Nantes and CNRS, Univ. of Nantes. (719.20)
2:40 Role of CD47 in Triple Negative Breast Cancer
S. Kaur, S.P. Singh, A.G. Elkahloun, W. Wu, T. Song, A. Arora and D.D.
Roberts. NCI, NIH, NIAID, NIH and NHGRI, NIH. (890.5)
2:55 495.3 Mechanisms
of FGF-Mediated Morphogenesis R. Marcucio. UCSF.
3:20 Discussion.