Molecular Mechanisms of Infection and Immunity

Theme organizers:

Brian Baker  Eric Sundberg
Brian Baker
Univ. of Notre Dame 
Eric Sundberg
Univ. of Maryland
School of Medicine 


Glycobiology in Infection and Immunity

Sunday, March 29, 2015, 3:55 PM - 6:10 PM • Room 257A/B

Follow the conversation: #immunology

 Chaired: B. Baker

3:55                        Chair’s Introduction.

4:00                        Award Lecturer Introduction and Award Presentation.

4:10      102.1       The Molecular Tool-Kit of Viral Hemorrhagic Fevers E. Ollmann Saphire, Z. Bornholdt, M. Fusco, D. Abelson, T. Hashiguchi, J. Lee, Y. Kawaoka, J. Dye and J. Crowe. The Scripps Res. Inst., Kyushu Univ., Univ. of Toronto, Univ. of Wisconsin-Madison, Univ. of Tokyo, U.S. Army Res. Inst. of Infect. Dis., Frederick, MD and Vanderbilt Univ. Sch. of Med.

4:35      106.1       Microbial Manipulation of Antibody Effector Functions E. Sundberg. Univ. of Maryland Sch. of Med.

5:00                        Pathogenetic Pathways of Aberrant O-Glycosylation of IgA1 in an Autoimmune Disease, IgA Nephropathy J. Novak, K. Takahashi, H. Suzuki, K. Yamada, C. Reily, T. Stewart, H. Ueda, S. Hall, Z. Moldoveanu, M. Raska, B.A. Julian and M.B. Renfrow. Univ. of Alabama at Birmingham. (718.26)

5:15      106.2       Glycan Targeted Vaccines for the Induction of Immunity Y. van Kooyk, C. Fehres, S. Horrevorts, S. Bruijns, H. Kalay, M. Ambrosini, J. Garcia Vallejo and W. Unger. VU Univ. Med. Ctr. Amsterdam.

5:40      106.3       Penetrating the Glycan Shield on HIV-1 P. Kwong. NIAID, NIH.

6:05                        Discussion.

Antigen Presentation and Recognition in Cellular Immunity

Monday, March 30, 2015, 9:45 AM - 12:00 PM • Room 257A/B

Follow the conversation: #immunology

Chaired: E. Sundberg

9:45                        Chair’s Introduction.

9:50      223.1       T Cell Receptor Recognition and the Composite Peptide/MHC Surface B. Baker. Univ. of Notre Dame.

10:15                      X-Ray Single Molecule Tracking Reveal Motions of Peptides in the Binding Groove of MHC II Regulated by DM H. Kozono, T. Miyabe, Y. Kozono and Y.C. Sasaki. Tokyo Univ. of Sci. and Univ. of Tokyo. (571.21)

10:30    223.2       The Molecular Signals that Regulate Gamma Delta T Cells E. Adams. Univ. of Chicago.

10:55                      A Novel Mouse Model to Study Chronic-Progressive Multiple Sclerosis F. Gomez-Rivera, I. Raphael and T.G. Forsthuber. Univ. of Puerto Rico at Ponce and Univ. of Texas at San Antonio. (888.20)

11:10                      Conserved Residues in TCR CDR Loops and Their Role in Influencing Antigen Recognition S.J. Blevins and B.M. Baker. Univ. of Notre Dame. (571.32)

11:25    223.3       Engineering T Cell Receptors for Optimal Affinities and Desired Specificities D.M. Kranz, D.T. Harris, J.D. Stone, S.N. Smith and A.S. Chervin. Univ. of Illinois, Urbana.

11:50                      Discussion.

Biochemistry and Systems Biology of Host-Pathogen Interactions

Tuesday, March 31, 2015, 3:55 PM - 6:10 PM • Room 257A/B

Chaired: D. M. Kranz

3:55                        Chair’s Introduction.

4:00      369.1       Metabolomics by Mass Spectrometry-Based Molecular Networking and Spatial Mapping N. Garg, D. Conrad and P.C. Dorrestein. UCSD.

4:25                        Rescuing Nod2, an Innate Immune Receptor of Bacterial Cell Wall Fragments, in Crohn Disease C.L. Grimes and V. Mohanan. Univ. of Delaware. (571.19)

4:40      369.2       Genetic Control of Immune Variation across the Human Population N. Hacohen. Massachusetts Gen. Hosp., Broad Inst. and Harvard Med. Sch.

5:05                        Mapping the DNA and RNA Binding Domains of the HIV Restriction Factor APOBEC3G H.C. Smith, W. McDougall, B. Polevoda, A. Friedman, R. Bennett and R. Stewart. Univ. of Rochester and OyaGen Inc., Rochester. (718.9)

5:20                        Validation of Recombinant Antibodies against Human Transcription Factors C. Griffin, S. Miersch, E. Marcon, S. Banerjee, J. Wells, M. Hornsby, A. Kossiakoff, S. Koide, M. Paduch, S. Sidhu and J. Moffat. Univ. of Toronto, UCSF and Univ. of Chicago. (571.13)

5:35      369.3       A Systems Approach to Dissecting Immunity A. Aderem. Seattle Biomed. Res. Inst.

6:00                        Discussion.

Visualizing Multicomponent Structures in Infection and Immunity

Wednesday, April 1, 2015, 9:00 AM - 11:15 AM • Room 257A/B

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 Chaired: E. Adams

9:00                        Chair’s Introduction.

9:05      488.1       Cryo-EM at Near-Atomic Resolution of Bacterial and Host Filaments E.H. Egelman. Univ. of Virginia.

9:30                        The Role of RING Dimerization in the E3 Ubiquitin Ligase Activity of the TRIM5α Retroviral Restriction Factor D. Ivanov, Z. Yudina, R. Johnson, N. Biris, A.B. Taylor, P.J. Hart and B. Demeler. Univ. of Texas Hlth. Sci. Ctr. at San Antonio. (888.9)

9:45      488.2       EM of Pathogen Secretion Systems: Unfolded Protein Transport across Membranes in Action T. Marlovits. Univ. Med. Ctr. Hamburg-Eppendorf and German Electron Synchrotron Ctr., Res. Inst. of Molec. Pathol., Vienna and Austrian Acad. of Sci.

10:10                      Differential Effects of Nanoparticle Surface-Functionalization on the Polarization Profiles of M1 and M2 Macrophages T. Syrovets, K. Haas, C. Loos, A. Musyanovych, V. Mailänder, K. Landfester and T. Simmet. Ulm Univ. and Max Planck Inst. for Polymer Res., Mainz. (716.9)

10:25                      Role of the U2AF Homology Motif in Human Tat-SF1 as a Cofactor for HIV-1 Splicing S. Loerch and C.L. Kielkopf. Univ. of Rochester. (718.21)

10:40    488.3       Analyzing Macromolecular Complexes In Situ Using Cellular Cryo-electron Microscopy D. Nicastro. Brandeis Univ.

11:05                      Discussion.