• ASBMB 2016 Annual Meeting

Bioinorganic Catalysis

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Theme Organizers: Carsten Krebs, Penn State and Vahe Bandarian, Univ. of Arizona   
The most up-to-date program information, view abstracts and plan your itinerary, download the EB2016 app or view online here: http://app.core-apps.com/eb2016

Sunday, April 3, 2016
San Diego Convention Center, Room 6C
4:00 pm - 6:15 pm
Mechanistic Studies of Metalloenzymes 
Session Chair: V. Bandarian

4:00                         Chair’s Introduction.

4:05     112.1          DNA-Mediated Signaling by Proteins with Iron- Sulfur Clusters. J. Barton. Caltech.     

4:30                         New  Insight  Into  the  Role  of  ATP    in  Iron Sulfur Cluster Scaffolding by the Mrp/Nbp35 Family of Cluster Scaffolds. D.L. Perlstein, J. Grossman. Boston Univ. (608.5)

4:45      112.2         Biosynthesis of the FeFe Hydrogenase Active Site. D.L.M. Suess, R.D. Britt. Univ. of California, Davis.

5:10                         A Surprising Shift in the Biosynthesis of Marine Meroterpenoids. Z. Miles, S. Deithelm, J. George, B. Moore. UCSD and Univ. of Adelaide. (608.4)

5:25                         New   Function   of   Enzyme   Involved in  the Formation of a Carbon-Nitrogen Triple Bond. M. Kobayashi. Grad. Sch. of Life and Envrn. Sci., Univ. of Tsukuba. (1084.1)

5:40     112.3          Exploring the Mechanistic Diversity of Non-heme-Iron Enzymes by Freeze-Quench Mössbauer Spectroscopy. C. Krebs, J.M. Bollinger; Jr. Penn State.

6:05                         Discussion.

Monday, April 4, 2016
San Diego Convention Center, Room 6C
9:45 am - 12:00 pm
Enzyme Dynamics and Enzyme Motions 
Session Chair: Tba.

9:45                         Chair’s Introduction.

9:50      240.1        Observations on the Cellular Dynamicsof a Metabolic Complex, the Purinosome. S. Benkovic, C.Y. Chan, D. Kim, A. Pedley, X. Zhuang. Penn State and Harvard/ HHMI, Cambridge.

10:15                       Large Scale Structural Rearrangement Provides Dual Control Over the Catalytic and Membrane Binding Activityof a Bacterial Serine Hydrolase. R.J. Johnson, M. Smith, W. Hart. Butler Univ. (833.6)

10:30   240.2         The Role of Millisecond Motions in Enzyme Function and Allostery.  P.  Loria. Yale

10:55                      Conservative Substitutions of BuriedAmino Acid Residues Distant from the Active Site of Horse Liver Alcohol Dehydrogenase Have Small Effects on Structure, Catalysis and Dynamics. B.V.  Plapp, K.  Shanmuganatham, R.S. Wallace, A.T-I. Lee. Univ. of Iowa. (833.5)

Control of Enzyme Function through Loop Dynamics. C.N. Chi, B. Vogeli, S. Bibow. ETH,Zurich. (835.2)

240.3     Separated at Birth, the Evolution of Kinase Dynamics over a Few Billion Years. D. Kern. HHMI,
Brandeis Univ.

11:50                       Discussion.


Tuesday, April 5, 2016
San Diego Convention Center, Room 6C
4:00 pm - 6:15 pm
Structural Studies of Complex Systems 
Session Chair: Tba.

4:00                         Chair’s Introduction.

4:05      390.1         Snapshots   of   Benzylsuccinate   Synthase: Getting a Handle on TolueneDegradation. C.L. Drennan, M.A. Funk. MIT and HHMI, Cambridge, MA.

4:30                         Biochemical      Characterization      of      Two Evolutionary Distant Ten-Eleven Translocation Enzymes and Their Utility in 5-Methylcytosine Sequencing in the Genomes at Single-Base Resolution. L. Saleh, E. Tamanaha, R. Vaisvila, J.E. Pais, N. Dai, S. Guan, I.R. Corrêa; Jr., Y. Zheng. New England Biolabs. (834.2)

4:45     390.2         Learning Drug Design from Nature – The Substrate-Protein and Protein-Protein Interactions of Fatty Acid and Polyketide Mega-Synthases. T. Valentic and S-C. Tsai. Univ. of California, Irvine.

5:10                         Protein-Protein    Interactions    Reduce  Ca2+-Requirements for Transglutaminase 2 Mediated Post- translational Modifications of α-Synuclein. T.N. Zeczycki, J.S. Viscomi. Brody Sch. of Med. at East Carolina Univ.(1083.16)
5:25                        Histone Deacetylase 6:Structure, Mechanism, and  Inhibitor  Selectivity.  Y.  Hai,  D.  Christianson.  Univ. of Pennsylvania.(1083.1)

5:40       390.3       Serial Femtosecond Crystallography Opens a New Era in Membrane Protein Structural Biology. P. Fromme. Biodesign Inst., Arizona State Univ.

6:05                         Discussion.


Wednesday, April 6, 2016
San Diego Convention Center, Room 6C
9:45 am- 12:00 pm
Radicals in Catalysis 
Session Chair: Carsten Krebs, Penn State 

9:45                      Chair’s Introduction.

9:50    501.1        Enzymes Involved in Secondary Metabolism   and RNA Modification. V. Bandarian. Univ. of Utah.

10:15                    Radical   SAM  Enzyme-Catalyzed  Formation of Thioether Crosslinks in Ribosomal-Produced Peptides: Formation of the RiPP Natural Product Thuricin CD by the Radical Sam Enzymes TrnC and TrnD. J.T. Jarrett, C.E. Holjencin. Univ. of Hawaii at Manoa. (1084.2)

10:30 501.2         Capturing a Cryptic Biosynthetic Intermediate Reveals Novel Enzyme Functions in Molybdenum Cofactor Biosynthesis. K. Yokoyama, B.M. Hover, N.K. Tonthat, M.A. Schumacher. Duke Univ. Med. Ctr.

10:55                    Structure of a Key Intermediate in   the Reaction Catalyzed by the Dual Specificity Methylase RlmN. E.L. Schwalm, S.Grove, A. Boal, S. Booker. Penn State and HHMI. (1085.1)

11:10                    Sifting throughthe Haystack to Find the Needle: Spatial Identification of a Structural Conduit for Transfer of Thermal Activation Energy in the Course of C-H Cleavage in Soybean Lipoxygenase. A. Offenbacher, S. Hu, A. Nguy, A. Iavarone, J. Klinman. Univ. of California, Berkeley. (1086.1)

11:25     501.3    Structural Basis for Divergent Reaction Outcomes in Iron(II)/2OG-Dependent Oxygenases. A. Boal. Penn State

11:50                      Discussion.