Summer 2022

Substrate Recruitment

New Routes for Kinases and Phosphatases

How do kinases and phosphatases recruit substrates? In recent years it has become apparent that our current understanding of substrate fidelity is oversimplified and many unrecognized parameters have a role in these critical interactions. 

It has been shown that substrate recruitment is often driven by the dynamic interactions of intrinsically disordered proteins and their cognate kinases or phosphatases through short linear motifs (SLiMs). 

These interactions were often missed in crystallographic analysis and protein interaction screens, which are geared toward detecting stable high affinity interactions. This evidence has been accumulating over the last few years, and it is now accepted that these interactions are key to substrate specificity. This new area research will be the topic of this conference.

Organizers

Wolfgang Peti
Wolfgang Peti
University of Arizona
Benjamin Turk
Benjamin Turk
Yale School of Medicine
Arminja Kettenbach
Arminja Kettenbach
Dartmouth Geisel School of Medicine