2021 ASBMB Annual Meeting

Sessions

Deepen your knowledge of research trends during sessions curated by pioneers and innovators.

Session tracks:

Other sessions:

Biochemistry of lipids and membranes

Novel roles of lipids in health and disease

Chair: Steven Claypool, Johns Hopkins School of Medicine

  • BSCL2/Seipin in lipid catabolism and lipodystrophy
    Weiqin Chen, Medical College of Georgia at Augusta University
  • Tissue-specific roles of cardiolipin in the control of systemic energy homeostasis
    Zachary Gerhart-Hines, University of Copenhagen
  • SPTLC1 mutations associated with early onset amyotrophic lateral sclerosis
    Teresa Dunn-Giroux, Uniformed Services University

How lipids impact the structure and function of membrane proteins

Chair: Steven Claypool, Johns Hopkins School of Medicine

  • Cardiolipin-dependent carriers
    Steven Claypool, Johns Hopkins School of Medicine
  • Structural basis of lipid scrambling and ion conduction by TMEM16 scramblases
    Alessio Accardi, Weill Cornell Medical College
  • Structural insights into TRPV channel gating
    Vera Moiseenkova-Bell, University of Pennsylvania

Membrane biogenesis and trafficking

Chair: Teresa Dunn-Giroux, Uniformed Services University

  • Lipid droplet proteome dynamics and lipotoxicity
    James Olzmann, University of California, Berkeley
  • Mechanistic approaches towards understanding physicochemical membrane homeostasis in the endoplasmic reticulum
    Robert Ernst, Saarland University
  • The role of VPS13 and related proteins in glycerolipid transport at membrane contact sites
    Karin Reinisch, Yale University School of Medicine
  • Cold-induced lipid dynamics in thermogenic fat
    Yu-Hua Tseng, Harvard Medical School

Glycosylation and extracellular matrix in development, repair and disease

Glycosylation and extracellular matrix in development, repair and cancer

Chair: Joanne Murphy-Ullrich

  • TGF-beta regulation by the matricellular protein thrombospondin 1
    Joanne Murphy-Ullrich, University of Alabama at Birmingham
  • Role of O-linked fucose-glucose disaccharide modification of thrombospondin type I repeats during protein folding and embryo development
    Bernadette Holdener, Stony Brook University
  • Are fibrillin-notch interactions important in development and disease?
    Lynn Sakai, Oregon Health & Science University
  • A genetic approach to display and dissect the cancer-associated O-glycoepitome
    Henrik Clausen, University of Copenhagen

Glycosylation and extracellular matrix in immunologic, inflammatory and infectious disease

  • Glycosylation in a common mechanism of colitis and sepsis
    Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute
  • Genome wide analysis of heparan sulfate assembly
    Jeffrey D. Esko, University of California, San Diego
  • PAMPs, DAMPs and SAMPs: Host glycans are self-associated molecular patterns, but subject to microbial molecular mimicry
    Ajit Varki, University of California, San Diego

Glycosylation and extracellular matrix in neurologic and metabolic diseases

Chair: Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute

  • Protective roles of O-GlcNAc in neurodegenerative diseases
    David Vocadlo, Simon Fraser University
  • The role of the O-GlcNAc transferase interactome in X-linked intellectual disability
    Lance Wells, University of Georgia Complex Carbohydrate Research Center
  • Role of ECM in the brain-gut connection
    Fernando Gomez-Pinilla, UCLA Brain Injury Research Center

Molecular mechanisms of cell signaling

Mechanosignaling

Chair: Wendy Gordon

  • Piezo1 activation gains traction
    Medha Pathak, University of California, Irvine
  • Mechanotransduction in vascular health and disease
    Martin Schwartz, Yale University
  • Mechanical force and notch signaling
    Wendy Gordon, University of Minnesota
  • Mechanisms linking mechanotransduction and cell metabolism
    Kris DeMali, University of Iowa

Post-translational modifications/signaling

Chair: Adrian Salic

  • Getting hedgehogs where they need to go: Cleavage activates dispatched for sonic hedgehog release
    Stacey Ogden, St. Jude Children’s Research Hospital
  • Rhomboid proteins in cell signaling
    Matthew Freeman, University of Oxford
  • Lipids and hedgehogs
    Adrian Salic, Harvard Medical School
  • Role of notch glycoslation in signaling
    Pamela Stanley, Albert Einstein College of Medicine

Emerging mechanisms of signaling

Chairs: Wendy Gordon and Adrian Salic

  • Tuning receptor signaling through ligand engineering
    Chris Garcia, Stanford University School of Medicine
  • Mechanisms of Wnt5a-Ror signaling in development and disease
    Henry Ho, University of California, Davis
  • Genetic and acquired heterotopic ossification are driven by a self-amplifying positive feedback loop of hedgehog signaling
    Yingzi Yang, Harvard Dental School

Molecular machines — structure and function

Molecular machines: New paradigms in structure, function and engineering

Chair: Stefanie Redemann, University of Virginia School of Medicine

  • Activation of the exocyst tethering complex for SNARE complex regulation and membrane fusion
    Mary Munson, UMass Medical School
  • Sugary coats: Synthesis and secretion of extracellular polysaccharides
    Jochen Zimmer, University of Virginia School of Medicine
  • The ESCRT membrane scission machine
    James Hurley, University of California, Berkeley

Molecular motors

Chair: Jochen Zimmer, University of Virginia

  • Integrated 3D tomography and computational modeling to study forces in metaphase spindles
    Stefanie Redemann, University of Virginia School of Medicine
  • Single molecule biophysics
    Carlos Bustamante, University of California, Berkeley
  • Myosin: Structure, function, regulation and disease
    Michelle Peckham, University of Leeds

Molecular motors in transport, biosynthesis, and energy transduction

Chair: Nathan Alder

  • Functional assembly of the mitochondrial protein transport machinery
    Nathan Alder, University of Connecticut
  • Structure of the alternative complex III from Flavobacterium johnsoniae in a supercomplex with Cytochrome c Oxidase
    Robert Gennis, University of Illinois
  • Nascent protein selection and triage at the ribosome exit site
    Shu-ou Shan, California Institute of Technology

New developments in metabolism

NAD synthesis, salvage and sirtuins in tissue health

Chair: Anne Murphy, Cytokinetics, Inc.

  • Mitochondrial NAD transport
    Joseph A. Baur, University of Pennsylvania
  • Chromatin regulation and genome maintenance by mammalian SIRT6 and SIRT7
    Katrin F. Chua, Stanford University and VA Palo Alto Health Care System

Control of cell fate by metabolic intermediates

Chair: Carla Koehler, University of California, Los Angeles

  • Microbiome catabolites as novel modulators of cellular glucose and energy metabolism
    Gary Williamson, Monash Univ
  • Metabolic modulation of cardiac health: The role of glucose and amino acids
    Rong Tian, University of Washington
  • Control of macrophage activation by coenzyme A
    Ajit Divakaruni, University of California, Los Angeles
  • A quantitative tissue-specific landscape of protein redox regulation during aging
    Edward Chouchani, Harvard University

New insights into control of metabolism by transporters

  • Glutamine transporter as a target of mTOR signaling modulating longevity
    John M. Sedivy, Brown University
  • Beneficial effects of inhibition of the mitochondrial pyruvate carrier and the mechanism of action of thiazolidinedione
    Anne Murphy, Cytokinetics, Inc.
  • Local and systemic actions of hepatic fatty acid oxidation
    Michael Wolfgang, Johns Hopkins University School of Medicine
  • Role of mitochondrial calcium in the maintenance of skeletal muscle homeostasis
    Anna Raffaello, University of Padova

RNA and disease

Noncoding RNAs and disease

Chair: Anita Hopper

  • tRNA: Splicing and subcellular dynamics
    Anita Hopper, Ohio State University
  • The role of tRNA derived small RNAs in gene regulation in normal tissues and cancer
    Mark Kay, Stanford University
  • The Piwi-piRNA pathway: A new paradigm in gene regulation
    Haifan Lin, Yale University
  • piRNA biogenesis and function in drosophila
    Mikiko Siomi, University of Tokyo

RNA modifications and disease

Chair: Eric Phizicky

  • RNA modification in cancer
    Jianjun Chen, Beckman Research Institute of City of Hope
  • RNA modifications in health and disease
    Tsutomu Suzuki, University of Tokyo
  • tRNA quality control: Mechanisms, evolution and implications for human disease
    Eric Phizicky, University Rochester Medical Center

RNA binding proteins and control of RNA biogenesis in disease

Chair: Takahiro Ito

  • Reprogramming cell fates by RNA binding proteins in stem cells and cancer
    Takahiro Ito, University of Georgia
  • The RNA exosome and genetic disease
    Anita Corbett, Emory University
  • RNA, chromatin and the coordinated control of gene expression
    Tracy Johnson, University of California, Los Angeles
  • Connections between mRNP cmposition and mRNA fate
    Guramrit Singh, Ohio State University

Understanding the rules of life

Cell decision making

Chair: Tanmay Lele

  • Lifelong analysis of key aging genes as determinants of lifespan in C. elegans
    Adriana San Miguel, North Carolina State University
  • Nuclear mechanics in migrating cells
    Tanmay Lele, University of Florida
  • Clocks, hourglasses and history-dependent clocks
    Arvind Murugan, University of Chicago

Computational approaches to regulation of gene expression

Chair: Polly Fordyce

  • Leveraging microfluidics for high-throughput studies of transcription factor/DNA binding
    Polly Fordyce, Stanford University
  • Synthetic NF-kB: A building approach to study complex signaling behaviors
    Ping Wei, Peking University Center for Quantitative Biology

Education and professional development

Who we are: Creating a culture of wellness in science

Chair: Daniel Dries, Juniata College

  • Preventing and overcoming harassment
    Alex Helman, National Academies of Sciences, Engineering and Medicine
  • Promoting mental wellbeing
    Nathan Vanderford, University of Kentucky
  • Mentorship best practices
    Joanne Kamens, Addgene

What we do: Choosing pedagogy over content

Chair: Nathan Vanderford, University of Kentucky

  • Grand challenges: Building interdisciplinary communities to tackle complex global issues
    Jodi Schwarz, Vassar College
  • Teaching biochemistry in context
    Daniel Dries, Juniata College
  • Reimagining STEM education to help underrepresented students thrive in the classroom
    Shannon Z. Jones, University of Richmond

JBC Herbert Tabor Early Career Investigator Awards

  • A low-potential terminal oxidase associated with the iron-only nitrogenase from the nitrogen-fixing bacterium Azotobacter vinelandii
    Febin Varghese, Washington State University
  • Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo
    Yue Yang, Weill Cornell Medicine
  • Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations
    Wehchano Zhao, University of Bonn
  • Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor
    Manisha Dagar, Amity Institute of Biotechnology
  • De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
    Kristine Lavrsen, University of Copenhagen