Sessions
Deepen your knowledge of research trends during sessions curated by pioneers and innovators.
Session tracks:
- Biochemistry of lipids and membranes
- Glycosylation and extracellular matrix in development, repair and disease
- Molecular mechanisms of cell signaling
- Molecular machines — structure and function
- New developments in metabolism
- RNA and disease
- Understanding the rules of life
- Education and professional development
Other sessions:
Biochemistry of lipids and membranes
Novel roles of lipids in health and disease
Chair: Steven Claypool, Johns Hopkins School of Medicine
- BSCL2/Seipin in lipid catabolism and lipodystrophy
Weiqin Chen, Medical College of Georgia at Augusta University - Tissue-specific roles of cardiolipin in the control of systemic energy homeostasis
Zachary Gerhart-Hines, University of Copenhagen - SPTLC1 mutations associated with early onset amyotrophic lateral sclerosis
Teresa Dunn-Giroux, Uniformed Services University
How lipids impact the structure and function of membrane proteins
Chair: Steven Claypool, Johns Hopkins School of Medicine
- Cardiolipin-dependent carriers
Steven Claypool, Johns Hopkins School of Medicine - Structural basis of lipid scrambling and ion conduction by TMEM16 scramblases
Alessio Accardi, Weill Cornell Medical College - Structural insights into TRPV channel gating
Vera Moiseenkova-Bell, University of Pennsylvania
Membrane biogenesis and trafficking
Chair: Teresa Dunn-Giroux, Uniformed Services University
- Lipid droplet proteome dynamics and lipotoxicity
James Olzmann, University of California, Berkeley - Mechanistic approaches towards understanding physicochemical membrane homeostasis in the endoplasmic reticulum
Robert Ernst, Saarland University - The role of VPS13 and related proteins in glycerolipid transport at membrane contact sites
Karin Reinisch, Yale University School of Medicine - Cold-induced lipid dynamics in thermogenic fat
Yu-Hua Tseng, Harvard Medical School
Glycosylation and extracellular matrix in development, repair and disease
Glycosylation and extracellular matrix in development, repair and cancer
Chair: Joanne Murphy-Ullrich
- TGF-beta regulation by the matricellular protein thrombospondin 1
Joanne Murphy-Ullrich, University of Alabama at Birmingham - Role of O-linked fucose-glucose disaccharide modification of thrombospondin type I repeats during protein folding and embryo development
Bernadette Holdener, Stony Brook University - Are fibrillin-notch interactions important in development and disease?
Lynn Sakai, Oregon Health & Science University - A genetic approach to display and dissect the cancer-associated O-glycoepitome
Henrik Clausen, University of Copenhagen
Glycosylation and extracellular matrix in immunologic, inflammatory and infectious disease
- Glycosylation in a common mechanism of colitis and sepsis
Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute - Genome wide analysis of heparan sulfate assembly
Jeffrey D. Esko, University of California, San Diego - PAMPs, DAMPs and SAMPs: Host glycans are self-associated molecular patterns, but subject to microbial molecular mimicry
Ajit Varki, University of California, San Diego
Glycosylation and extracellular matrix in neurologic and metabolic diseases
Chair: Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute
- Protective roles of O-GlcNAc in neurodegenerative diseases
David Vocadlo, Simon Fraser University - The role of the O-GlcNAc transferase interactome in X-linked intellectual disability
Lance Wells, University of Georgia Complex Carbohydrate Research Center - Role of ECM in the brain-gut connection
Fernando Gomez-Pinilla, UCLA Brain Injury Research Center - The role of metabolism in modulating radiation fibrosis
Fei-Fei Liu, Princess Margaret Cancer Centre, Toronto
Molecular mechanisms of cell signaling
Mechanosignaling
Chair: Wendy Gordon
- Piezo1 activation gains traction
Medha Pathak, University of California, Irvine - Mechanotransduction in vascular health and disease
Martin Schwartz, Yale University - Mechanical force and notch signaling
Wendy Gordon, University of Minnesota - Mechanisms linking mechanotransduction and cell metabolism
Kris DeMali, University of Iowa
Post-translational modifications/signaling
Chair: Adrian Salic
- Getting hedgehogs where they need to go: Cleavage activates dispatched for sonic hedgehog release
Stacey Ogden, St. Jude Children’s Research Hospital - Rhomboid proteins in cell signaling
Matthew Freeman, University of Oxford - Lipids and hedgehogs
Adrian Salic, Harvard Medical School - Role of notch glycoslation in signaling
Pamela Stanley, Albert Einstein College of Medicine
Emerging mechanisms of signaling
Chairs: Wendy Gordon and Adrian Salic
- Tuning receptor signaling through ligand engineering
Chris Garcia, Stanford University School of Medicine - Cellular communication via adhesion
Demet Arac, University of Chicago - Mechanisms of Wnt5a-Ror signaling in development and disease
Henry Ho, University of California, Davis - Genetic and acquired heterotopic ossification are driven by a self-amplifying positive feedback loop of hedgehog signaling
Yingzi Yang, Harvard Dental School
Molecular machines — structure and function
Molecular machines: New paradigms in structure, function and engineering
Chair: Stefanie Redemann, University of Virginia School of Medicine
- Activation of the exocyst tethering complex for SNARE complex regulation and membrane fusion
Mary Munson, UMass Medical School - Sugary coats: Synthesis and secretion of extracellular polysaccharides
Jochen Zimmer, University of Virginia School of Medicine - The ESCRT membrane scission machine
James Hurley, University of California, Berkeley - HiFi molecular transmission via crisscross cooperativity
William Shih, Harvard University
Molecular motors
Chair: Jochen Zimmer, University of Virginia
- Integrated 3D tomography and computational modeling to study forces in metaphase spindles
Stefanie Redemann, University of Virginia School of Medicine - Single molecule biophysics
Carlos Bustamante, University of California, Berkeley - Myosin: Structure, function, regulation and disease
Michelle Peckham, University of Leeds - Watching a fine-tuned molecular machine at work: Structural and functional studies of the 26S proteasome
Andreas Martin, University of California, Berkeley
Molecular motors in transport, biosynthesis, and energy transduction
Chair: Nathan Alder
- Functional assembly of the mitochondrial protein transport machinery
Nathan Alder, University of Connecticut - Structure of the alternative complex III from Flavobacterium johnsoniae in a supercomplex with Cytochrome c Oxidase
Robert Gennis, University of Illinois - An AAA-ATPase using an airlock-like translocation mechanism for folded proteins
Roland Beckmann, Ludwig-Maximilians-Universität - Nascent protein selection and triage at the ribosome exit site
Shu-ou Shan, California Institute of Technology
New developments in metabolism
NAD synthesis, salvage and sirtuins in tissue health
Chair: Anne Murphy, Cytokinetics, Inc.
- Mitochondrial NAD transport
Joseph A. Baur, University of Pennsylvania - Chromatin regulation and genome maintenance by mammalian SIRT6 and SIRT7
Katrin F. Chua, Stanford University and VA Palo Alto Health Care System
Control of cell fate by metabolic intermediates
Chair: Carla Koehler, University of California, Los Angeles
- Microbiome catabolites as novel modulators of cellular glucose and energy metabolism
Gary Williamson, Monash Univ - Metabolic modulation of cardiac health: The role of glucose and amino acids
Rong Tian, University of Washington - Control of macrophage activation by coenzyme A
Ajit Divakaruni, University of California, Los Angeles - A quantitative tissue-specific landscape of protein redox regulation during aging
Edward Chouchani, Harvard University
New insights into control of metabolism by transporters
- Glutamine transporter as a target of mTOR signaling modulating longevity
John M. Sedivy, Brown University - Beneficial effects of inhibition of the mitochondrial pyruvate carrier and the mechanism of action of thiazolidinedione
Anne Murphy, Cytokinetics, Inc. - Local and systemic actions of hepatic fatty acid oxidation
Michael Wolfgang, Johns Hopkins University School of Medicine - Role of mitochondrial calcium in the maintenance of skeletal muscle homeostasis
Anna Raffaello, University of Padova
RNA and disease
Noncoding RNAs and disease
Chair: Anita Hopper
- tRNA: Splicing and subcellular dynamics
Anita Hopper, Ohio State University - The role of tRNA derived small RNAs in gene regulation in normal tissues and cancer
Mark Kay, Stanford University - The Piwi-piRNA pathway: A new paradigm in gene regulation
Haifan Lin, Yale University - piRNA biogenesis and function in drosophila
Mikiko Siomi, University of Tokyo
RNA modifications and disease
Chair: Eric Phizicky
- RNA modification in cancer
Jianjun Chen, Beckman Research Institute of City of Hope - RNA modifications in health and disease
Tsutomu Suzuki, University of Tokyo - tRNA quality control: Mechanisms, evolution and implications for human disease
Eric Phizicky, University Rochester Medical Center
RNA binding proteins and control of RNA biogenesis in disease
Chair: Takahiro Ito
- Reprogramming cell fates by RNA binding proteins in stem cells and cancer
Takahiro Ito, University of Georgia - The RNA exosome and genetic disease
Anita Corbett, Emory University - RNA, chromatin and the coordinated control of gene expression
Tracy Johnson, University of California, Los Angeles - Connections between mRNP cmposition and mRNA fate
Guramrit Singh, Ohio State University
Understanding the rules of life
Cell decision making
Chair: Tanmay Lele
- Lifelong analysis of key aging genes as determinants of lifespan in C. elegans
Adriana San Miguel, North Carolina State University - Nuclear mechanics in migrating cells
Tanmay Lele, University of Florida - Clocks, hourglasses and history-dependent clocks
Arvind Murugan, University of Chicago
Computational approaches to regulation of gene expression
Chair: Polly Fordyce
- Leveraging microfluidics for high-throughput studies of transcription factor/DNA binding
Polly Fordyce, Stanford University - Synthetic NF-kB: A building approach to study complex signaling behaviors
Ping Wei, Peking University Center for Quantitative Biology - Neal Devaraj, University of California, San Diego
Best practices for preventing/managing incidences of harassment in the workplace
- Suzanne Barbour, University of Georgia
Education and professional development
Who we are: Creating a culture of wellness in science
Chair: Daniel Dries, Juniata College
- Preventing and overcoming harassment
Alex Helman, National Academies of Sciences, Engineering and Medicine - Promoting mental wellbeing
Nathan Vanderford, University of Kentucky - Mentorship best practices
Joanne Kamens, Addgene
What we do: Choosing pedagogy over content
Chair: Nathan Vanderford, University of Kentucky
- Grand challenges: Building interdisciplinary communities to tackle complex global issues
Jodi Schwarz, Vassar College - Teaching biochemistry in context
Daniel Dries, Juniata College - Reimagining STEM education to help underrepresented students thrive in the classroom
Shannon Z. Jones, University of Richmond
JBC Herbert Tabor Early Career Investigator Awards
- A low-potential terminal oxidase associated with the iron-only nitrogenase from the nitrogen-fixing bacterium Azotobacter vinelandii
Febin Varghese, Washington State University - Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo
Yue Yang, Weill Cornell Medicine - Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations
Wehchano Zhao, University of Bonn - Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor
Manisha Dagar, Amity Institute of Biotechnology - De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
Kristine Lavrsen, University of Copenhagen