Sessions

Biochemistry of lipids and membranes

Novel roles of lipids in health and disease

Chair: Steven Claypool, Johns Hopkins School of Medicine

• BSCL2/Seipin in lipid catabolism and lipodystrophy
  Weiqin Chen, Medical College of Georgia at Augusta University
• Tissue-specific roles of cardiolipin in the control of systemic energy homeostasis
  Zachary Gerhart-Hines, University of Copenhagen
• SPTLC1 mutations associated with early onset amyotrophic lateral sclerosis
  Teresa Dunn-Giroux, Uniformed Services University

How lipids impact the structure and function of membrane proteins

Chair: Steven Claypool, Johns Hopkins School of Medicine

• Cardiolipin-dependent carriers
  Steven Claypool, Johns Hopkins School of Medicine
• Structural basis of lipid scrambling and ion conduction by TMEM16 scramblases
  Alessio Accardi, Weill Cornell Medical College
• Structural insights into TRPV channel gating
  Vera Moiseenkova-Bell, University of Pennsylvania

Membrane biogenesis and trafficking

Chair: Teresa Dunn-Giroux, Uniformed Services University

• Lipid droplet proteome dynamics and lipotoxicity
  James Olzmann, University of California, Berkeley
• Mechanistic approaches towards understanding physicochemical membrane homeostasis in the endoplasmic reticulum
  Robert Ernst, Saarland University
• The role of VPS13 and related proteins in glycerolipid transport at membrane contact sites
  Karin Reinisch, Yale University School of Medicine
• Cold-induced lipid dynamics in thermogenic fat
  Yu-Hua Tseng, Harvard Medical School

Glycosylation and extracellular matrix in development, repair and disease

Glycosylation and extracellular matrix in development, repair and cancer

Chair: Joanne Murphy-Ullrich

• TGF-beta regulation by the matricellular protein thrombospondin 1
  Joanne Murphy-Ullrich, University of Alabama at Birmingham
• Role of O-linked fucose-glucose disaccharide modification of thrombospondin type I repeats during protein folding and embryo development
  Bernadette Holdener, Stony Brook University
• Are fibrillin-notch interactions important in development and disease?
  Lynn Sakai, Oregon Health & Science University
• A genetic approach to display and dissect the cancer-associated O-glycoepitome
  Henrik Clausen, University of Copenhagen

Glycosylation and extracellular matrix in immunologic, inflammatory and infectious disease

• Glycosylation in a common mechanism of colitis and sepsis
  Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute
• Genome wide analysis of heparan sulfate assembly
  Jeffrey D. Esko, University of California, San Diego
• PAMPs, DAMPs and SAMPs: Host glycans are self-associated molecular patterns, but subject to microbial molecular mimicry
  Ajit Varki, University of California, San Diego

Glycosylation and extracellular matrix in neurologic and metabolic diseases

Chair: Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute

• Protective roles of O-GlcNAc in neurodegenerative diseases
  David Vocadlo, Simon Fraser University
• The role of the O-GlcNAc transferase interactome in X-linked intellectual disability
  Lance Wells, University of Georgia Complex Carbohydrate Research Center
• Role of ECM in the brain-gut connection
  Fernando Gomez-Pinilla, UCLA Brain Injury Research Center
• The role of metabolism in modulating radiation fibrosis
  Fei-Fei Liu, Princess Margaret Cancer Centre, Toronto

Molecular mechanisms of cell signaling

Mechanosignaling

Chair: Wendy Gordon

• Piezo1 activation gains traction
  Medha Pathak, University of California, Irvine
• Mechanotransduction in vascular health and disease
  Martin Schwartz, Yale University
• Mechanical force and notch signaling
  Wendy Gordon, University of Minnesota
• Mechanisms linking mechanotransduction and cell metabolism
  Kris DeMali, University of Iowa

Post-translational modifications/signaling

Chair: Adrian Salic

• Getting hedgehogs where they need to go: Cleavage activates dispatched for sonic hedgehog release
  Stacey Ogden, St. Jude Children’s Research Hospital
• Rhomboid proteins in cell signaling
  Matthew Freeman, University of Oxford
• Lipids and hedgehogs
  Adrian Salic, Harvard Medical School
• Role of notch glycoslation in signaling
  Pamela Stanley, Albert Einstein College of Medicine

Emerging mechanisms of signaling

Chairs: Wendy Gordon and Adrian Salic

• Tuning receptor signaling through ligand engineering
  Chris Garcia, Stanford University School of Medicine
• Cellular communication via adhesion
  Demet Arac, University of Chicago
• Mechanisms of Wnt5a-Ror signaling in development and disease
  Henry Ho, University of California, Davis
• Genetic and acquired heterotopic ossification are driven by a self-amplifying positive feedback loop of hedgehog signaling
  Yingzi Yang, Harvard Dental School

Molecular machines — structure and function

Molecular machines: New paradigms in structure, function and engineering

Chair: Stefanie Redemann, University of Virginia School of Medicine

• Activation of the exocyst tethering complex for SNARE complex regulation and membrane fusion
  Mary Munson, UMass Medical School
• Sugary coats: Synthesis and secretion of extracellular polysaccharides
  Jochen Zimmer, University of Virginia School of Medicine
• The ESCRT membrane scission machine
  James Hurley, University of California, Berkeley
• HiFi molecular transmission via crisscross cooperativity
  William Shih, Harvard University

Molecular motors

Chair: Jochen Zimmer, University of Virginia

• Integrated 3D tomography and computational modeling to study forces in metaphase spindles
  Stefanie Redemann, University of Virginia School of Medicine
• Single molecule biophysics
  Carlos Bustamante, University of California, Berkeley
• Myosin: Structure, function, regulation and disease
  Michelle Peckham, University of Leeds
• Watching a fine-tuned molecular machine at work: Structural and functional studies of the 26S proteasome
  Andreas Martin, University of California, Berkeley

Molecular motors in transport, biosynthesis, and energy transduction

Chair: Nathan Alder

• Functional assembly of the mitochondrial protein transport machinery
  Nathan Alder, University of Connecticut
• Structure of the alternative complex III from Flavobacterium johnsoniae in a supercomplex with Cytochrome c Oxidase
  Robert Gennis, University of Illinois
• An AAA-ATPase using an airlock-like translocation mechanism for folded proteins
  Roland Beckmann, Ludwig-Maximilians-Universität
• Nascent protein selection and triage at the ribosome exit site
  Shu-ou Shan, California Institute of Technology

New developments in metabolism

NAD synthesis, salvage and sirtuins in tissue health

Chair: Anne Murphy, Cytokinetics, Inc.

• Mitochondrial NAD transport
  Joseph A. Baur, University of Pennsylvania
• Chromatin regulation and genome maintenance by mammalian SIRT6 and SIRT7
  Katrin F. Chua, Stanford University and VA Palo Alto Health Care System

Control of cell fate by metabolic intermediates

Chair: Carla Koehler, University of California, Los Angeles

• Microbiome catabolites as novel modulators of cellular glucose and energy metabolism
  Gary Williamson, Monash Univ
• Metabolic modulation of cardiac health: The role of glucose and amino acids
  Rong Tian, University of Washington
• Control of macrophage activation by coenzyme A
  Ajit Divakaruni, University of California, Los Angeles
• A quantitative tissue-specific landscape of protein redox regulation during aging
  Edward Chouchani, Harvard University

New insights into control of metabolism by transporters

• Glutamine transporter as a target of mTOR signaling modulating longevity
  John M. Sedivy, Brown University
• Beneficial effects of inhibition of the mitochondrial pyruvate carrier and the mechanism of action of thiazolidinedione
  Anne Murphy, Cytokinetics, Inc.
• Local and systemic actions of hepatic fatty acid oxidation
  Michael Wolfgang, Johns Hopkins University School of Medicine
• Role of mitochondrial calcium in the maintenance of skeletal muscle homeostasis
  Anna Raffaello, University of Padova

RNA and disease

Noncoding RNAs and disease

Chair: Anita Hopper

• tRNA: Splicing and subcellular dynamics
  Anita Hopper, Ohio State University
• The role of tRNA derived small RNAs in gene regulation in normal tissues and cancer
  Mark Kay, Stanford University
• The Piwi-piRNA pathway: A new paradigm in gene regulation
  Haifan Lin, Yale University
• piRNA biogenesis and function in drosophila
  Mikiko Siomi, University of Tokyo

RNA modifications and disease

Chair: Eric Phizicky

• RNA modification in cancer
  Jianjun Chen, Beckman Research Institute of City of Hope
• RNA modifications in health and disease
  Tsutomu Suzuki, University of Tokyo
• tRNA quality control: Mechanisms, evolution and implications for human disease
  Eric Phizicky, University Rochester Medical Center

RNA binding proteins and control of RNA biogenesis in disease

Chair: Takahiro Ito

• Reprogramming cell fates by RNA binding proteins in stem cells and cancer
  Takahiro Ito, University of Georgia
• The RNA exosome and genetic disease
  Anita Corbett, Emory University
• RNA, chromatin and the coordinated control of gene expression
  Tracy Johnson, University of California, Los Angeles
• Connections between mRNP cmposition and mRNA fate
  Guramrit Singh, Ohio State University

Understanding the rules of life

Cell decision making

Chair: Tanmay Lele

• Lifelong analysis of key aging genes as determinants of lifespan in C. elegans
  Adriana San Miguel, North Carolina State University
• Nuclear mechanics in migrating cells
  Tanmay Lele, University of Florida
• Clocks, hourglasses and history-dependent clocks
  Arvind Murugan, University of Chicago

Computational approaches to regulation of gene expression

Chair: Polly Fordyce

• Leveraging microfluidics for high-throughput studies of transcription factor/DNA binding
  Polly Fordyce, Stanford University
• Synthetic NF-kB: A building approach to study complex signaling behaviors
  Ping Wei, Peking University Center for Quantitative Biology
• Neal Devaraj, University of California, San Diego

Best practices for preventing/managing incidences of harassment in the workplace

• Suzanne Barbour, University of Georgia

Education and professional development

Who we are: Creating a culture of wellness in science

Chair: Daniel Dries, Juniata College

• Preventing and overcoming harassment
  Alex Helman, National Academies of Sciences, Engineering and Medicine
• Promoting mental wellbeing
  Nathan Vanderford, University of Kentucky
• Mentorship best practices
  Joanne Kamens, Addgene

What we do: Choosing pedagogy over content

Chair: Nathan Vanderford, University of Kentucky

• Grand challenges: Building interdisciplinary communities to tackle complex global issues
  Jodi Schwarz, Vassar College
• Teaching biochemistry in context
  Daniel Dries, Juniata College
• Reimagining STEM education to help underrepresented students thrive in the classroom
  Shannon Z. Jones, University of Richmond

JBC Herbert Tabor Early Career Investigator Awards

• A low-potential terminal oxidase associated with the iron-only nitrogenase from the nitrogen-fixing bacterium Azotobacter vinelandii
  Febin Varghese, Washington State University
• Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo
  Yue Yang, Weill Cornell Medicine
• Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations
  Wehchano Zhao, University of Bonn
• Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor
  Manisha Dagar, Amity Institute of Biotechnology
• De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
  Kristine Lavrsen, University of Copenhagen