2021 ASBMB Annual Meeting

Sessions

Deepen your knowledge of research trends during sessions curated by pioneers and innovators.

Session tracks:

Other sessions:

Biochemistry of lipids and membranes

Novel roles of lipids in health and disease

Tuesday, April 27, 11:15 a.m. – 1 p.m.

Chair: Steven Claypool, Johns Hopkins School of Medicine

  • BSCL2/Seipin in lipid catabolism and lipodystrophy
    Weiqin Chen, Medical College of Georgia at Augusta University
  • Tissue-specific roles of cardiolipin in the control of systemic energy homeostasis
    Zachary Gerhart-Hines, University of Copenhagen
  • SPTLC1 mutations associated with early onset amyotrophic lateral sclerosis
    Teresa Dunn-Giroux, Uniformed Services University

How lipids impact the structure and function of membrane proteins

Wednesday, April 28, 11:45 a.m. – 1:30 p.m.

Chair: Steven Claypool, Johns Hopkins School of Medicine

  • Cardiolipin-dependent carriers
    Steven Claypool, Johns Hopkins School of Medicine
  • Structural basis of lipid scrambling and ion conduction by TMEM16 scramblases
    Alessio Accardi, Weill Cornell Medical College
  • Structural insights into TRPV channel gating
    Vera Moiseenkova-Bell, University of Pennsylvania

Membrane biogenesis and trafficking

Thursday, April 29, 11:45 a.m. – 1:30 p.m.

Chair: Teresa Dunn-Giroux, Uniformed Services University

  • Lipid droplet proteome dynamics and lipotoxicity
    James Olzmann, University of California, Berkeley
  • Mechanistic approaches towards understanding physicochemical membrane homeostasis in the endoplasmic reticulum
    Robert Ernst, Saarland University
  • The role of VPS13 and related proteins in glycerolipid transport at membrane contact sites
    Karin Reinisch, Yale University School of Medicine
  • Cold-induced lipid dynamics in thermogenic fat
    Yu-Hua Tseng, Harvard Medical School

Glycosylation and extracellular matrix in development, repair and disease

Glycosylation and extracellular matrix in development, repair and cancer

Tuesday, April 27, 11:15 a.m. – 1 p.m.

Chair: Joanne Murphy-Ullrich

  • TGF-beta regulation by the matricellular protein thrombospondin 1
    Joanne Murphy-Ullrich, University of Alabama at Birmingham
  • Role of O-linked fucose-glucose disaccharide modification of thrombospondin type I repeats during protein folding and embryo development
    Bernadette Holdener, Stony Brook University
  • Are fibrillin-notch interactions important in development and disease?
    Lynn Sakai, Oregon Health & Science University
  • A genetic approach to display and dissect the cancer-associated O-glycoepitome
    Henrik Clausen, University of Copenhagen

Glycosylation and extracellular matrix in immunologic, inflammatory and infectious disease

Wednesday, April 28, 11:45 a.m. – 1:30 p.m.
  • Glycosylation in a common mechanism of colitis and sepsis
    Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute
  • Genome wide analysis of heparan sulfate assembly
    Jeffrey D. Esko, University of California, San Diego
  • PAMPs, DAMPs and SAMPs: Host glycans are self-associated molecular patterns, but subject to microbial molecular mimicry
    Ajit Varki, University of California, San Diego

Glycosylation and extracellular matrix in neurologic and metabolic diseases

Thursday, April 29, 11:45 a.m. – 1:30 p.m.

Chair: Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute

  • Protective roles of O-GlcNAc in neurodegenerative diseases
    David Vocadlo, Simon Fraser University
  • The role of the O-GlcNAc transferase interactome in X-linked intellectual disability
    Lance Wells, University of Georgia Complex Carbohydrate Research Center
  • Role of ECM in the brain-gut connection
    Fernando Gomez-Pinilla, UCLA Brain Injury Research Center
  • The role of metabolism in modulating radiation fibrosis
    Fei-Fei Liu, Princess Margaret Cancer Centre, Toronto

Molecular mechanisms of cell signaling

Mechanosignaling

Tuesday, April 27, 11:15 a.m. – 1 p.m.

Chair: Wendy Gordon

  • Piezo1 activation gains traction
    Medha Pathak, University of California, Irvine
  • Mechanotransduction in vascular health and disease
    Martin Schwartz, Yale University
  • Mechanical force and notch signaling
    Wendy Gordon, University of Minnesota
  • Mechanisms linking mechanotransduction and cell metabolism
    Kris DeMali, University of Iowa

Post-translational modifications/signaling

Wednesday, April 28, 11:45 a.m. – 1:30 p.m.

Chair: Adrian Salic

  • Getting hedgehogs where they need to go: Cleavage activates dispatched for sonic hedgehog release
    Stacey Ogden, St. Jude Children’s Research Hospital
  • Rhomboid proteins in cell signaling
    Matthew Freeman, University of Oxford
  • Lipids and hedgehogs
    Adrian Salic, Harvard Medical School
  • Role of notch glycoslation in signaling
    Pamela Stanley, Albert Einstein College of Medicine

Emerging mechanisms of signaling

Thursday, April 29, 11:45 a.m. – 1:30 p.m.

Chairs: Wendy Gordon and Adrian Salic

  • Tuning receptor signaling through ligand engineering
    Chris Garcia, Stanford University School of Medicine
  • Cellular communication via adhesion
    Demet Arac, University of Chicago
  • Mechanisms of Wnt5a-Ror signaling in development and disease
    Henry Ho, University of California, Davis
  • Genetic and acquired heterotopic ossification are driven by a self-amplifying positive feedback loop of hedgehog signaling
    Yingzi Yang, Harvard Dental School

Molecular machines — structure and function

Molecular machines: New paradigms in structure, function and engineering

Tuesday, April 27, 11:15 a.m. – 1 p.m.

Chair: Stefanie Redemann, University of Virginia School of Medicine

  • Activation of the exocyst tethering complex for SNARE complex regulation and membrane fusion
    Mary Munson, UMass Medical School
  • Sugary coats: Synthesis and secretion of extracellular polysaccharides
    Jochen Zimmer, University of Virginia School of Medicine
  • The ESCRT membrane scission machine
    James Hurley, University of California, Berkeley
  • HiFi molecular transmission via crisscross cooperativity
    William Shih, Harvard University

Molecular motors

Wednesday, April 28, 11:45 a.m. – 1:30 p.m.

Chair: Jochen Zimmer, University of Virginia

  • Integrated 3D tomography and computational modeling to study forces in metaphase spindles
    Stefanie Redemann, University of Virginia School of Medicine
  • Single molecule biophysics
    Carlos Bustamante, University of California, Berkeley
  • Myosin: Structure, function, regulation and disease
    Michelle Peckham, University of Leeds
  • Watching a fine-tuned molecular machine at work: Structural and functional studies of the 26S proteasome
    Andreas Martin, University of California, Berkeley

Molecular motors in transport, biosynthesis, and energy transduction

Thursday, April 29, 11:45 a.m. – 1:30 p.m.

Chair: Nathan Alder

  • Functional assembly of the mitochondrial protein transport machinery
    Nathan Alder, University of Connecticut
  • Structure of the alternative complex III from Flavobacterium johnsoniae in a supercomplex with Cytochrome c Oxidase
    Robert Gennis, University of Illinois
  • An AAA-ATPase using an airlock-like translocation mechanism for folded proteins
    Roland Beckmann, Ludwig-Maximilians-Universit├Ąt
  • Nascent protein selection and triage at the ribosome exit site
    Shu-ou Shan, California Institute of Technology

New developments in metabolism

NAD synthesis, salvage and sirtuins in tissue health

Tuesday, April 27, 11:15 a.m. – 1 p.m.

Chair: Anne Murphy, Cytokinetics, Inc.

  • Mitochondrial NAD transport
    Joseph A. Baur, University of Pennsylvania
  • Chromatin regulation and genome maintenance by mammalian SIRT6 and SIRT7
    Katrin F. Chua, Stanford University and VA Palo Alto Health Care System

Control of cell fate by metabolic intermediates

Wednesday, April 28, 11:45 a.m. – 1:30 p.m.

Chair: Carla Koehler, University of California, Los Angeles

  • Microbiome catabolites as novel modulators of cellular glucose and energy metabolism
    Gary Williamson, Monash Univ
  • Metabolic modulation of cardiac health: The role of glucose and amino acids
    Rong Tian, University of Washington
  • Control of macrophage activation by coenzyme A
    Ajit Divakaruni, University of California, Los Angeles
  • A quantitative tissue-specific landscape of protein redox regulation during aging
    Edward Chouchani, Harvard University

New insights into control of metabolism by transporters

Thursday, April 29, 11:45 a.m. – 1:30 p.m.
  • Glutamine transporter as a target of mTOR signaling modulating longevity
    John M. Sedivy, Brown University
  • Beneficial effects of inhibition of the mitochondrial pyruvate carrier and the mechanism of action of thiazolidinedione
    Anne Murphy, Cytokinetics, Inc.
  • Local and systemic actions of hepatic fatty acid oxidation
    Michael Wolfgang, Johns Hopkins University School of Medicine
  • Role of mitochondrial calcium in the maintenance of skeletal muscle homeostasis
    Anna Raffaello, University of Padova

RNA and disease

Noncoding RNAs and disease

Tuesday, April 27, 11:15 a.m. – 1 p.m.

Chair: Anita Hopper

  • tRNA: Splicing and subcellular dynamics
    Anita Hopper, Ohio State University
  • The role of tRNA derived small RNAs in gene regulation in normal tissues and cancer
    Mark Kay, Stanford University
  • The Piwi-piRNA pathway: A new paradigm in gene regulation
    Haifan Lin, Yale University
  • piRNA biogenesis and function in drosophila
    Mikiko Siomi, University of Tokyo

RNA modifications and disease

Wednesday, April 28, 11:45 a.m. – 1:30 p.m.

Chair: Eric Phizicky

  • RNA modification in cancer
    Jianjun Chen, Beckman Research Institute of City of Hope
  • RNA modifications in health and disease
    Tsutomu Suzuki, University of Tokyo
  • tRNA quality control: Mechanisms, evolution and implications for human disease
    Eric Phizicky, University Rochester Medical Center

RNA binding proteins and control of RNA biogenesis in disease

Thursday, April 29, 11:45 a.m. – 1:30 p.m.

Chair: Takahiro Ito

  • Reprogramming cell fates by RNA binding proteins in stem cells and cancer
    Takahiro Ito, University of Georgia
  • The RNA exosome and genetic disease
    Anita Corbett, Emory University
  • RNA, chromatin and the coordinated control of gene expression
    Tracy Johnson, University of California, Los Angeles
  • Connections between mRNP cmposition and mRNA fate
    Guramrit Singh, Ohio State University

Understanding the rules of life

Cell decision making

Tuesday, April 27, 11:15 a.m. – 1 p.m.

Chair: Tanmay Lele

  • Lifelong analysis of key aging genes as determinants of lifespan in C. elegans
    Adriana San Miguel, North Carolina State University
  • Nuclear mechanics in migrating cells
    Tanmay Lele, University of Florida
  • Clocks, hourglasses and history-dependent clocks
    Arvind Murugan, University of Chicago

Computational approaches to regulation of gene expression

Wednesday, April 28, 11:45 a.m. – 1:30 p.m.

Chair: Polly Fordyce

  • Leveraging microfluidics for high-throughput studies of transcription factor/DNA binding
    Polly Fordyce, Stanford University
  • Synthetic NF-kB: A building approach to study complex signaling behaviors
    Ping Wei, Peking University Center for Quantitative Biology
  • Neal Devaraj, University of California, San Diego

Best practices for preventing/managing incidences of harassment in the workplace

Thursday, April 29, 11:45 a.m. – 1:30 p.m.
  • Suzanne Barbour, University of Georgia

Education and professional development

Who we are: Creating a culture of wellness in science

Tuesday, April 27, 11:15 a.m. – 1 p.m.

Chair: Daniel Dries, Juniata College

  • Preventing and overcoming harassment
    Alex Helman, National Academies of Sciences, Engineering and Medicine
  • Promoting mental wellbeing
    Nathan Vanderford, University of Kentucky
  • Mentorship best practices
    Joanne Kamens, Addgene

What we do: Choosing pedagogy over content

Wednesday, April 28, 11:45 a.m. – 1:30 p.m.

Chair: Nathan Vanderford, University of Kentucky

  • Grand challenges: Building interdisciplinary communities to tackle complex global issues
    Jodi Schwarz, Vassar College
  • Teaching biochemistry in context
    Daniel Dries, Juniata College
  • Reimagining STEM education to help underrepresented students thrive in the classroom
    Shannon Z. Jones, University of Richmond

JBC Herbert Tabor Early Career Investigator Awards

Friday, April 30, 11:15 a.m. – 12:30 p.m.
  • A low-potential terminal oxidase associated with the iron-only nitrogenase from the nitrogen-fixing bacterium Azotobacter vinelandii
    Febin Varghese, Washington State University
  • Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo
    Yue Yang, Weill Cornell Medicine
  • Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations
    Wehchano Zhao, University of Bonn
  • Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor
    Manisha Dagar, Amity Institute of Biotechnology
  • De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
    Kristine Lavrsen, University of Copenhagen