Lipid research webinars

John Burke and Mike Airola organized a highly successful webinar series over Zoom to make up for conference cancellations in 2020. The LRD is proud to host this series of presentations from young researchers. You can watch recordings of past presentations by clicking on the links below:

May 8, 2020: Lipid signaling

Structural basis for activation of PLC-gamma isozymes | Nicole Hajicek, UNC-Chapel Hill
Small changes – big impact? How lipid diversity affects signaling | Milena Schuhmacher

May 15, 2020: Metabolic Regulation

Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase | Yaxi Wang, Texas A&M University

May 22, 2020: ESCRT complexes in membrane biology

Mechanism of membrane reshaping by ESCRT complexes| Henry Nguyen, UCSF
ESCRT-III and ER-PM contact sites maintain lipid homeostasis | Jeff Jorgenson, Cornell University

May 29, 2020: Lipid Droplet Biology

Neutral lipids regulate amphipathic helix affinity for model lipid droplets | Aymeric Cholay, CNRS
Protein machinery of lipid droplet formation | Jeeyun Chung, Harvard Medical School

June 5, 2020: Lipid storage and utilization

The role of bmm/ATGL in regulating male-female differences in fat storage and breakdown | Lianna Wat, Rideout lab, University of British Columbia
Synthesis of endosomal PI(4)P is required for secretory granule maturation | Cheng-I Jonathan Ma, Brill Lab, The Hospital for Sick Children

June 12, 2020: Lipids in transmembrane protein structure

Lipid transport for the bacterial outer membrane through an envelope-spanning tunnel | Georgia Isom, Bhabha-Ekiert lab, New York University
Understanding the molecular determinants for GPCR recognition by beta-arrestins | John Janetzko, Kobilka lab, Stanford University

June 19 : ER resident proteins, membranes and droplets

Membrane protein biosynthesis at the endoplasmic reticulum | Tino Pleiner, Vorhees lab, California Institute of Technology
A functional interaction between Snx14 and delta-9 desaturase SCD1 maintains ER homeostasis | Sanchari Datta, Henne lab, UT Southwestern Medical Center

June 26: Structure and signaling in triglyceride metabolism

Structure and catalytic mechanism of a human triacylglycerol synthesis enzyme | Xuewu Sui, Walther and Farese lab, Harvard Medical Center

September 6: Lipids in viral infection

Unexpected free fatty acid binding pocket in the cryo-EM structure of SARS-CoV-2 spike protein | Christine Toelzer, University of Bristol
Structures and distributions of SARS-CoV-2 spike proteins on intact virions | Zunlong Ke, Medical Research Council Laboratory of Molecular Biology

September 16: Lipids in autophagy

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes | Yohei Ohashi, Medical Research Council Laboratory of Molecular Biology

A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy | Chunmei Chang, University of California, Berkeley

September 23: Dynamic roles for lipids at membrane contact sites

PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria |Yael Alon, University of California, Davis

Phagolysosome resolution requires contacts with the endoplasmic reticulum and phosphatidylinositol-4-phosphate signalling | Roni Levin, The Hospital for Sick Children, Toronto

September 30: Phospholipases and disease

Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements | Angeline Lyon, Purdue University

Phospholipase D1 ablation disrupts mouse longitudinal hippocampal axis organization and functioning | Tiago Gil Oliveira, University of Minho

October 7: Signaling to lipids in flies and worms

Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in C. elegans | Sena Mutlu, Baylor College of Medicine

Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis in an ER stress-dependent manner | Brittany Martinez, University of Virginia

This page is updated once a month. To find the most recent webinars, you can also visit ASBMB webinars on-demand and look for “LRD seminar series.” Please allow a few days for seminars to be uploaded.