World Cancer Day


Essay: Disappointed – by cancer
Biochemist Jennifer DuBois of Montana State University reacts to her diagnosis and treatment with professional dismay. Read her first-person essay

Essay: Entropy happens
“I took Hannah to the pediatrician because of a trivial complaint. During the routine exam, her doctor felt a mass in Hannah’s abdomen.” Read this touching first-person essay from our archived series “Derailed But Undeterred” 

Feature: Chasing cancer with dogs
Treating canine cancers is helping researchers learn more about human forms of the disease. Read our cover story

Feature: A rare brain tumor kills 250 children every year in North America
The discovery of a mutation in an unexpected gene has given researchers new drug targets and brings hope that someday this cancer can be tamed. Read our cover story (with audio and video)

Molecular & Cellular Proteomics

Q&A with Associate Editor Pierre Thibault
Pierre Thibault, an associate editor for the journal Molecular & Cellular Proteomics, and his research group are studying changes in the proteome in the context of cancer and immunology. Read this interview with Thibault.

News: How radiotherapies vanquish cancer cells
A paper in the journal Molecular & Cellular Proteomics describes efforts to understand the regulatory effects of particle beams on the structure and signaling pathways of cancerous cells. Read about the paper

News: Decoding ovarian cancer’s dark signaling pathways
Researchers write in a paper in the journal Molecular & Cellular Proteomics about using proteotranscriptomic techniques to uncover associations between factors expressed by high-grade serous ovarian adenocarcinoma and the likelihood of patient survival. Read about the paper.

Research findings: Spatial tissue proteomics quantifies inter- and intra- tumor heterogeneity in hepatocellular carcinoma. Read more

Research findings: Multi-omics integration reveals the landscape of pro-metastasis metabolism in hepatocellular carcinoma. Read more

Journal of Biological Chemistry

News: Expanding the reach of therapeutic antibodies
A group of researchers has developed an approach to efficiently produce antibodies that can bind to two different target molecules simultaneously, a long-desired innovation in the field of cancer immunotherapy. Read more

News: A metabolic pathway that feeds liver cancer
A little-studied gene may explain how some liver cancer cells obtain the nutrition they need to proliferate, according to new research published in the Journal of Biological Chemistry. Read about the paper

Feature: When Deb Johnson called the JBC offices in 2010, she had a unique request
She needed a few copies of the journal that she could tear up and turn into art. Read about her effort to raise awareness of head and neck cancer

Research findings: Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells. Read more

Journal of Lipid Research

News: Sphingolipid metabolism protects kidneys from cisplatin
In pursuit of more effective cancer treatment, researchers have uncovered how the kidneys protect themselves or recover from chemotherapy-induced damage. Read about their Journal of Lipid Research paper.

Research findings: Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury. Read more

Research findings: Targeting the lipid metabolic axis ACSL/SCD in colorectal cancer progression by therapeutic miRNAs: miR-19b-1 role. Read more