November 2013
 

Fishing out the details of how tilapia tolerate salt


In a recent Molecular & Cellular Proteomics paper, researchers looked into the molecular details of how tilapia change protein expression in their gills to accommodate different concentrations of salt.

 

New thematic review series begins: “Living History of Lipids”


The November issue of the Journal of Lipid Research marks the start of a special thematic review series titled “Living History of Lipids.” As the title of the series suggests, this set of thematic reviews will explore what is known about lipids, but it will do so in the unique context of recognizing the forward-thinking pioneers whose hard work, determination and, in many cases, accidental yet astonishing experimental discoveries have led to the knowledge of the field as we know it today.

 

Thematic series on fat-soluble vitamins continues: vitamin E


Continuing the Journal of Lipid Research’s thematic series on fat-soluble vitamins, the September issue addresses vitamin E with two reviews covering current research on this topic. In his introduction to the series, editorial board member William S. Blaner describes vitamin E as “the enigmatic one,” because we still do not know specific pathways or molecular targets of vitamin E that help explain its role as an essential nutrient.

 

FoxO3 and Sirt6 play an important role in regulating SREBP-2 and cholesterol homeostasis


In a recent article in the Journal of Lipid Research, a research team led by X. Charlie Dong at Indiana University School of Medicine reported that Sirt6 plays a critical role in the regulation of SREBP-2.

 

Francisella tularensis: a biological weapon


Recent papers in the Journal of Biological Chemistry and the journal Molecular & Cellular Proteomics report probable mechanisms by which Francisella leads to a lethal infection.

 

Fatty acid synthase and Galen of Pergamon


Mammalian fatty acid synthase, known as FAS, is a type I fatty acid synthase, indicating that all of the activities required to synthesize palmitate from simple precursors are present in a single multifunctional polypeptide. FAS is required for life, because conventional deletion of the fasn gene in mice is embryonically lethal. However, tissue-specific deletion of fasn has revealed an amazing spectrum of biological functions driven by de novo lipogenesis.

 

‘You hear the screech of rubber hitting the road’


The University of Missouri hosted a regional career symposium focused on science outreach and communication in September. More than 125 people registered for the one-day event, co-sponsored and co-organized by the ASBMB. The vast majority of attendees were graduate students, but postdoctoral fellows, faculty members and science-communication professionals also were present.

 

Broadcasting scientists


The social network Google+ has a platform for video broadcasts known as Hangouts on Air. HOAs allow video, with up to 10 presenters, to be broadcast live on the Internet. After the event, the video is archived on YouTube.

 

Assembling a toolkit for biochemistry and molecular biology educators


What is the best way to build a Web-based toolkit for undergraduate faculty members to share best practices, activities and assessments in biochemistry and molecular biology? Members of the ASBMB's Research Coordination Network steering committee led discussions recently to answer this question and have since put together a BMB educator toolkit wish list. Here's an overview.

 

Turning a failure into a success down the road


Eleftherios P. Diamandis writes, in part: "The famous professional heavyweight boxer Rocky Marciano retired undefeated, scoring 49 wins, a still-standing record. But very few know that Rocky was knocked down twice in his professional career. In both cases, he got up and finally won the fights. There are numerous other examples of startling comeback wins in almost all sports. Such turnarounds require courage, perseverance and a relentless fighting spirit. But this is not enough."

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