January 2013

The multitasking endoplasmic reticulum in health and disease


The multitasking endoplasmic reticulum in health and disease

May 1 – 4
Airlie Center, Warrenton, Va.
Early registration and abstract submission deadline: Feb. 1
More information: www.asbmb.org/MultitaskingER
Organizers: John Bergeron, McGill University; Tommy Nilsson, McGill University; and William Balch, The Scripps Research Institute

Photo of John Bergeron  Photo of Tommy Nilsson  Photo of William Balch 
Bergeron Nilsson Balch

The endoplasmic reticulum is now recognized as a central control point for compartmental organization of the eukaryotic cell. Beyond managing the biosynthesis, folding and degradation of proteins that make up at least one-third of the eukaryotic genome, it regulates membrane trafficking that drives cell specialization during development. It is essential for compartmentalization of the nucleus and the structure of chromatin. It performs specialized functions such as detoxification by the liver and management of the metabolome by the pancreatic beta-cell. More recently, a flurry of proposed new activities associated with the ER include the regulation of mitochondrial function, peroxisome biogenesis, autophagosome/phagoautosome formation as well as specialized ER domains that link to antigen cross-presentation in the immune system and cross-talk with viral and bacterial pathogens. The apparent old and new multitasking activities of the ER now serve as the catalyst to bring together a diverse pool of investigators to explore in depth and challenge traditional views of ER function that will help define the ER as a heretofore unanticipated central regulator of eukaryotic function through its ability to manage and integrate metabolic, biosynthetic, degradation and signaling pathways. We look forward to your participation.

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