ASBMB broadcasts

ASBMB live

ASBMB Live is a virtual series that brings together experts and advocates from around the world to discuss the latest scientific discoveries and advances. Watch our collection of past broadcasts and follow us on Google+ to join the conversation and RSVP to future Google+ Hangouts.

New angle in cancer research through a rare pediatric brain tumor

Diffuse intrinsic pontine glioma, or DIPG, is a rare brain tumor kills 250 children every year in North America. In an ASBMB Today cover story, we explored how the discovery of a mutation in an unexpected gene has given researchers new drug targets and brings hope that someday this cancer can be tamed. This broadcast includes experts on epigenetics and pediatric medicine, along with a parent of a child who died of DIPG.

Read ASBMB Today’s story:
"A new angle" by Rajendrani Mukhopadhyay

A spoonful of sugar

Translating basic research into clinical therapies is a difficult process, especially when the disease being studied is not well understood. This broadcast brought together researchers who are working on congenital disorders of glycosylation –  a rare set of disorders that result from mistakes in glycosylation pathways, and patient advocates. Hudson Freeze of the Sanford Burnham Prebys Medical Discovery Institute, winner of the 2013 Golden Goose Award, a world-renowned expert in glycosylation disorders and the subject of an ASBMB Today cover story, was one of our guests.

Read ASBMB Today’s story: "A good ambassador" by Rajendrani Mukhopadhyay

Debate over vitamin D

Are we getting enough vitamin D? The answer, it seems, depends upon which expert you ask. An ASBMB Today coverstory explored a longstanding controversy over the dietary recommendations for vitamin D. In this broadcast, we interviewed experts who were highlighted in the story.

Read ASBMB Today’s story: "Vitamin D: How much is enough?" by Rajendrani Mukhopadhyay

ASBMB Journal Club is a video-based discussion with authors of papers in ASBMB journals. Authors describe the ins and outs of their research.

Biomarkers — discovery, validation and applications

This broadcast featured some of the biggest names in the field: Ruedi Aebersold at the Swiss Federal Institute of Technology and a associate editor for the journal Molecular & Cellular Proteomics, Daniel Liebler of Vanderbilt University and an MCP associate editor, and Karin Rodland at the Pacific Northwest National Laboratory and an MCP author.

Nitric oxide and epigenetics

In this broadcast, we chatted with Douglas Thomas and Jason Hickok at the University of Illinois at Chicago about their “Paper of the Week” in the Journal of Biological Chemistry. Their work focuses on the effects of nitric oxide on epigenetic mechanisms

Read the related paper: "Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases"

Recent research advances in vitamin A

It's been 100 years since fat-soluble vitamins were first described. The Journal of Lipid Research putforward a review series on the latest research into vitamin A, one of the fat-soluble vitamins. In this broadcast, we chatted with William Blaner at Columbia University, the JLR editorial board member who oversaw the review series and works on vitamin A. We discussed what is known and not known aboutthis essential dietary component.

Read the related review series: "Fat-soluble vitamins"

Vitamin E: the enigmatic one!

"The enigmatic one" is how William Blaner at Columbia University described vitamin E in an editorial he wrote for the Journal of Lipid Research. To learn more about this mysterious molecule, we talked with Blaner and Maret Traber at Oregon State University about the latest research into vitamin E.

Read the related review series: "Fat-soluble vitamins"

Science in a shell: what mussels tell us

In humans and most other animals, offspring get all their mitochondrial DNA from their mothers. But in mussels and other related bivalves, fathers also give their offspring their mitochondrial DNA. In a paper in the journal Molecular & Cellular Proteomics, researchers proposed a new model to explain this mechanism of mitochondrial DNA inheritance, which is called doubly uniparental inheritance, or DUI. The model also puts forward a possible explanation for sex determination in mussels, the mechanisms of which are not known. In this broadcast, we were joined by the authors of the MCP paper. The discussion delved into how we can get a better understanding of the function and evolution of mitochondrial DNA.

Read ASBMB Today’s story: "On mitochondrial DNA, mating and mussels" by Rajendrani Mukhopadhyay  
Read the related paper: "Proteomic analysis of eggs from Mytilus edulis females differing in mitochondrial DNA transmission mode" 

Pass the salt: how tilapia deal with changing salinity of water

In this broadcast, we were joined by Dietmar Kueltz of the University of California, Davis, lead author of a paper in the journal Molecular & Cellular Proteomics about how tilapia change protein expression in their gills to accommodate for different concentrations of salt. The research has implications for fish farming as well as our understanding of how animals like tilapia may tolerate the effects of climate change.

Read ASBMB Today’s story: "Fishing out the details of how tilapia tolerate salt" by Rajendrani Mukhopadhyay
Read the related paper: "Quantitative Molecular Phenotyping of Gill Remodeling in a Cichlid Fish Responding to Salinity Stress"   

Beyond breast cancer: a role for BRCA1

The BRCA1 gene has become synonymous with breast cancer. But, like most genes, it has a multitude of effects that defy this simplified association. In this broadcast, we discuss the role of BRCA1 in skeletal muscle metabolic function with Journal of Lipid Research author Espen Spangenburg from the University of Maryland.

Read ASBMB Today’s story: "Breast cancer gene involved in skeletal muscle energy metabolism" by Rajendrani Mukhopadhyay 
Read the related paper: "BRCA1 is a novel regulator of metabolic function in skeletal muscle"