JBC: Discovering novel drugs to target GPCRs


As part of a recent minireview series published in the Journal of Biological Chemistry and coordinated by editor Henrik Dohlman at the University of North Carolina, pioneering scientific experts in the field of G-protein–coupled receptors offer valuable insights into the challenges of targeting a wider variety of GPCRs as well as some very creative solutions to those challenges.

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JLR: More good news about aspirin


We see commercials every day that remind us that we have no idea when a heart attack or stroke will occur. Then, shortly after that reminder, there is a plug for aspirin. Cardiovascular disease has been a leading cause of death in developed countries for years, and we know aspirin can improve cardiovascular health, specifically through its ability to disrupt prostaglandin synthesis and reduce coagulation. Recently researchers reported a new effect of aspirin. In the Journal of Lipid Research, the researchers reported that salicylate, an unacetylated form of aspirin, improves cholesterol levels by targeting AMP-activated protein kinase, or Ampk, in macrophages.

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