Program Schedule

3:00 pm - 6:00 pm  Attendees may pick up badges and meeting materials
6:30 pm - 7:30 pm Dinner, all attendees 
  Keynote Speaker  
7:30 pm - 8:30 pm Robert Weinberg, Whitehead Inst. for Biomedical Research 
Influence of Epigenetic Programs on Cancer Progression
7:30 am - 8:30 am      Breakfast, on-property attendees
8:45 am - 9:00 am Symposium Organizer Welcome
9:00 am - 12:30 pm RAS Biochemistry, Cell Biology and Signaling   
  Frank McCormick, UCSF, Session Chair
9:00 am - 9:30 am Frank McCormick, UCSF
Progress in targeting K-Ras
9:30 am - 10:00 am John Hancock, UT Houston
Lipid binding specificity of the KRAS membrane anchor: molecular mechanisms and attendant therapeutic possibilities
10:00 am - 10:30 am Debbie Morrison, NCI
Divide and Conquer:  New Approaches to Disrupt Raf Kinase Signaling 
10:30 am - 11:00 am Networking Coffee Break
11:00 am - 11:30 am Dhirendra Simanshu, Frederick National Lab
Structural insights into the role of SPRED1 as a negative regulator of RAS/MAPK pathway
11:30 am - 12:00 pm Matt Vander Heiden, MIT
Strategies to target the metabolism of Ras-driven cancers
12:00 pm - 12:15 pm Mark Philips, NYU
Hexokinase 1 is an effector of KRAS4A
12:15 pm - 12:30 pm Martin McMahon, Huntsman Cancer Inst. of the Univ. of Utah
Protective autophagy elicited by RAF->MEK->ERK inhibition suggests a combination treatment strategy for RAS-driven cancers
12:30 pm - 2:00 pm  Lunch, all attendees. 
Speaker meet and greet available for grads and postdocs.  Advanced sign-up required.
2:00 pm - 4:00 pm  Free Time
4:00 pm - 5:30 pm Poster Session 1
6:00 pm - 7:00 pm  Dinner, all attendees  
7:00 pm - 9:30 pm RAS and Cancer: Animal Models   
  Kevin Haigis, Harvard Med. Sch., Session Chair
7:00 pm - 7:30 pm Allan Balmain, UCSF
Evolution of Ras-mutant cancers from initiation to metastasis: lessons from the mouse
7:30 pm - 8:00 pm Trever Bivona, UCSF
  RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers
8:00 pm - 8:15 pm  Break
8:15 pm - 8:45 pm Christopher Counter, Duke Univ.
Codon bias, the silent secret of RAS genes
8:45 pm - 9:15 pm Kevin Haigis, Harvard Med. Sch.
Genetics and proteomics of K-Ras mutant mouse models
9:15 pm - 9:30 pm Christin Burd, The Ohio State Univ. 
Defining Mutation-Specific NRAS Functions in Melanoma
7:00 am - 8:15 am  Breakfast, on-property attendees
8:30 am - 1:00 pm RAS, Metabolism and Tumor Microenvironment
  Dafna Bar-Sagi, NYU, Session Chair
8:30 am - 9:00 am Nabeel Bardeesy, Massachusetts General Hosp.
Cooperative interactions between the GNAS and KRAS oncogenes in reprogramming lipid metabolism and driving pancreatic cancer
9:00 am - 9:30 am Dafna Bar-Sagi, NYU
Function and Regulation of Protein Scavenging in Mutant Ras Tumor Cells
9:30 am - 10:00 am Alec Kimmelman, NYU
Identifying metabolic dependencies in pancreatic cancer
10:00 am - 10:30 am Networking Coffee Break
10:30 am - 11:00 am Ken Olive, Columbia Univ.
Pancreatic cancer-selective targeting through genetic induction of ferroptosis
11:00 am - 11:30 am Marina Pasca di Magliano, Univ. of Michigan
Oncogenic Kras and the pancreatic cancer microenvironment
11:30 am - 12:00 pm Mara Sherman, Oregon Health and Science Univ.
Growth-permissive lipid metabolic networks in the pancreatic tumor microenvironment
12:00 pm - 12:30 pm Karen Cichowski, Harvard Med. Sch.
Developing therapies for Ras-driven cancers
12:30 pm - 12:45 pm Timothy Tran, Frederick National Lab for Cancer Research
Structural basis of impaired GTP hydrolysis in oncogenic mutants of KRAS
12:45 pm - 1:00 pm Marcus Kelly, Stanford Univ. Sch. of Med.
Proteomic and Genetic Interaction Mapping Reveals New Ras Pathway Effectors and Regulators
1:00 pm - 2:00 pm  Lunch, all attendees.  
Speaker meet and greet available for grads and postdocs.  Advanced sign-up required.
2:00 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session 2
6:00 pm - 7:00 pm Dinner, all attendees
7:00 pm - 9:45 pm Anti-RAS Drug Development  
  Kevan Shokat, UCSF, Session Chair
7:00 pm - 7:30 pm Kevan Shokat, UCSF
Direct inhibitors of K-Ras
7:30 pm - 7:45 pm Geoffery Clark, University of Louisville 
Novel direct RAS inhibitors
7:45 pm - 8:00 pm Sharon Campbell, UNC Sch of Med
Targeting RAS for anticancer therapeutics
8:00 pm - 8:15 pm Break
8:15 pm - 8:45 pm Neal Rosen, Memorial Sloan Kettering Cancer Center
Talk title tba.
8:45 pm - 9:15 pm Shiva Malek, Genentech
 Harnessing kinase dependent and independent functions of RAF kinases to treat RAS mutant tumors
9:15 pm - 9:30 pm Mohamed Ismail, The Francis Crick Inst.
Characterization of a cyclic peptide that binds the p110α-RBD and blocks its interaction with RAS
9:30 pm - 9:45 pm Ulf Peters, Wellspring Biosciences, Inc.
Drugging an undruggable pocket: the biochemical mechanism of covalent KRAS(G12C) inhibitors
Check-out Reminder Check out is no later than 11:00 am.  Baggage may be brought to the session room.
7:00 am - 8:15 am Breakfast, on-property attendees
8:30 am - 11:30 am RAS and Cancer Immunotherapy  
  David Scheinberg, Memorial Sloan Kettering Cancer Center, Session Chair
8:30 am - 9:00 am Channing Der, UNC Sch of Med
Targeting RAS: Will MYC Do the Trick?
9:00 am - 9:15 am
Adrienne Cox, UNC at Chapel Hill
ERK inhibition increases pancreatic cancer dependence on autophagy
9:15 am - 9:45 am David Scheinberg, Memorial Sloan Kettering Cancer Center
How the immune system may affect RAS and RAS may affect the immune system
9:45 am - 10:15 am James Yang, NCI
Clinical trials using T-Cells engineered to target G12D and G12V RAS mutations
10:15 am - 10:45 am Networking Coffee Break
10:45 am - 11:00 am Marcus Ruscetti, Memorial Sloan Kettering Cancer Ctr.
Targeted Therapy-Induced Senescence Enhances Immune Surveillance of KRAS Mutant Lung Cancers
11:00 am - 11:30 am Kwok-Kin Wong, NYU School of Medicine
  The impact of lkb1 loss on the tumor immune microenvironment in kras driven lung cancer.
11:30 am      Meeting program concludes.  
11:30 am Grab and Go boxed lunches will be available outside of the session room.
11:45 am      Confirmed shuttle riders must be waiting outside the Black Bear Lodge to load the shuttle to Albany International Airport (ALB).  Sign-up during registration process was required.
12:00 pm      Shuttle departs promptly at 12:00 pm.