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Protein Nonfolding as a Regulatory Phenomenon

Theme organizers:


Elizabeth Rhoades
Yale Univ.


Scott Showalter
The Pennsylvania State Univ.


Mediating Protein Interactions: Is Folding Required?

Sunday, March 29, 2015, 3:55 PM - 6:10 PM • Room 258C

Follow the conversation: #protein

Chaired: E. Rhoades

3:55                        Chair’s Introduction.

4:00      109.1       Mechanisms of Folding upon Binding J. Clarke. Univ. of Cambridge.

4:25                        Changes in Water Availability or Molecular Crowding Induce Folding in Instrinsically Disordered Stress Proteins from Plants A.A. Covarrubias, C.L. Cuevas-Velazquez, L.Y. Rivera-Najera, D.F. Rendon-Luna, G. Saab-Rincón, M.A. Martinez-Yamout, H. Dyson and C. Amero. Biotechnol. Inst., UNAM, Cuernavaca, The Scripps Res. Inst. and UAEM, Autonomous Univ. of Mexico State, Cuernavaca. (712.11)

4:40      109.2       The Role of Protein Disorder and Self-Association in the Formation of Cellular Bodies T. Mittag, M.R. Marzahn, J. Lee, A. Palud, S. Marada, A. Nourse, J.P. Taylor and S.K. Ogden. St. Jude Children’s Res. Hosp.

5:05                        Specificity of the Yeast Auxilin Homolog Swa2 in [URE3] Prion Propagation Is Solely Determined by the TPR Domain J.K. Hines, E.M. Troisi, M.E. Rockman and E.E. Oliver. Lafayette Col., PA. (713.5)

5:20                        "Protein Un-Design": Evolutionary Origins of Native DNA-Binding Architectures in Unfolded Polypeptides  M.A. Weiss, J.D. Racca, Y-S. Chen and N.B. Phillips. Case Western Reserve Univ. (563.12) 

5:35      109.3       Probing Protein Intrinsic Disorder and Allostery Modulation at Single-Molecule Resolution A. Deniz. The Scripps Res. Inst.

6:00                        Discussion.

Regulating Functional Interactions by Dysfunctional Proteins

Monday, March 30, 2015, 9:45 AM - 12:00 PM • Room 258C

Follow the conversation: #protein

Chaired: C. Camacho

9:45                        Chair’s Introduction.

9:50      226.1       Functional Interactions of Disease-Linked Disordered Proteins: Alpha-Synuclein, Tau and Complexin D. Eliezer. Weill Cornell Med. Col.

10:15                      Structure and Assembly of Functional Amyloids S. Perrett. Chinese Acad. of Sci., Beijing. (563.9)

10:30    226.2       Determining a Functional Mechanism for a Dysfunctional Protein E. Rhoades, G. Cobb, A. Melo, J. Coraor, S. Elbaum-Garfinkle and X-H. Li. Yale Univ.

10:55                      Transient Expression of Intrinsically Disordered Proteins Fuels the Emergence of Adaptive Protein-Based Heritable Traits D. Jarosz. Stanford Univ. Sch. of Med. (882.15)

11:10                      Misfolded Proinsulin Presenting an Unpaired Thiol Is Recognized and Targeted for ERAD by Specific Lumenal Components in the ER A-M. Kelemen and PJ. Lin. Grad. Col. of Biomed. Sci., Western Univ. of Hlth. Sci. (881.5)

11:25    226.3       The Aggregation Mechanism of Amyloidogenic Proteins Involved in Neurodegenerative Disorders C. Stultz. MIT.

11:50                      Discussion.

Defining Protein Disorder

Tuesday, March 31, 2015, 3:55 PM - 6:10 PM • Room 258C

Follow the conversation: #protein

Chaired: S. Metallo

3:55                        Chair’s Introduction.

4:00      372.1       Fuzziness – Disorder in Protein Complexes – Imparts Versatility on Signalling M. Fuxreiter. Univ. of Debrecen, Hungary.

4:25                        An Intrinsically Disordered Region of MBD2 Both Recruits the Histone Deacetylase Core Complex of NuRD and Modifies Kinetics of DNA Binding D.C. Williams, M. Desai and G.D. Ginder. Univ. of North Carolina at Chapel Hill and Virginia Commonwealth Univ. (712.14)

4:40      372.2       Assessing Intrinsically Disordered Protein Structure and Function through Carbon Detected NMR S. Showalter, D. Sahu, M. Bastidas and C.W. Lawrence. Penn State.

5:05                        Intrinsic Structural Disorder Observed in the Cell Cycle Regulatory GTPase Nucleostemin T.H. Daman and V.L. Robinson. Univ. of Connecticut. (712.4)

5:20                        Order-to-Disorder Transitions in BECN1 Regulate Autophagy S. Sinha, Y. Mei, K. Glover, M. Su, A. Ramanathan and C. Colbert. North Dakota State Univ. and Oak Ridge Natl. Lab. (712.16)

5:35      372.3       Disorder in Protein Switches J. Gsponer. Univ. of British Columbia.

6:00                        Discussion.

Targeting Disorder with Small Molecules

Wednesday, April 1, 2015, 9:00 AM - 11:15 AM • Room 258C

Follow the conversation: #protein

Chaired: S. Showalter

9:00                        Chair’s Introduction.

9:05      491.1       Biophysical Studies of Amyloid Formation and Its Inhibition S.E. Radford. Univ. of Leeds.

9:30                        Ligand-Induced Conformational Change Propagates NEMO-Mediated NF-κB Signaling R. Shaffer, S. Cote, K. Allen and A. Whitty. Boston Univ. (563.6)

9:45      491.2       Specificity and Promiscuity in Small Molecule Binding to Intrinsically Disordered Protein Regions S. Metallo. Georgetown Univ.

10:10                      Safe Inhibition of Amyloid Proteins Toxicity without Protein Specificity G. Bitan. UCLA. (564.2)

10:25                      Fragment-Based Drug Discovery Targeting KEAP1/Nrf2 Binding M. Zhong, A. Lynch, S. Jehle, D. Kozakov, S. Vajda, K. Allen and A. Whitty. Boston Univ. (712.20)

10:40    491.3       On Modulating the Regulatory Role of Intrinsically Disordered Proteins Using Small Molecules C. Camacho. Univ. of Pittsburgh.

11:05                      Discussion.