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Protein Nonfolding as a Regulatory Phenomenon

Abstract deadline extended to Monday, November 10 at 5PM, EST

Theme organizers:


Elizabeth Rhoades
Yale Univ.


Scott Showalter
The Pennsylvania State Univ.

This theme is made up of four symposia, one scheduled each day of the meeting, Sun – Wed.  Please read below for invited speaker and session schedule information.  In addition to the invited talks listed below, short talks will be selected from the submitted abstracts.  To be considered for a volunteered talk in this theme, submit your abstract to an ASBMB topic category number: 2090-2108, by the November 6th submission deadline.  All volunteered abstracts will be programmed for poster presentation.  Those selected for oral presentation will also present a poster.  Programming notifications will be sent in mid-January.  We look forward to seeing you at the Boston Convention and Exhibition Center, BCEC, March 28 – April 1, 2015.

Mediating Protein Interactions: Is Folding Required?

Sunday, March 29, 2015, 3:55 PM - 6:10 PM
Room 258C

Session Chair: Elizabeth Rhoades, Yale Univ.

Invited Speakers:

Jane Clark, Univ. of Cambridge
Mechanisms of folding upon binding

Ashok Deniz, The Scripps Res. Inst.
Probing protein intrinsic disorder and allostery modulation at single-molecule resolution

Tanja Mittag, St. Jude Children's Res. Hosp.
The role of substrate disorder and multivalency in regulating ubiquitination

Regulating Functional Interactions by Dysfunctional Proteins

Monday, March 30, 2015, 9:45 AM - 12:00 PM
Room 258C

Session Chair: Carlos Camacho, Univ. of Pittsburgh         

Invited Speakers:

David Eliezer, Weill Cornell Med. Col.
The amyloid state of proteins in health and disease

Elizabeth Rhoades, Yale Univ.
Determining a functional mechanism of a dysfunctional protein

Collin Stultz, MIT
The Aggregation Mechanism of Amyloidogenic Proteins Involved in Neurodegenerative Disorders

Defining Protein Disorder

Tuesday, March 31, 2015, 3:55 PM - 6:10 PM
Room 258C

Session Chair: Steve Metallo, Georgetown Univ.

Invited Speakers:

Mónika Fuxreiter, Univ. of Debrecen
Fuzziness - disorder in protein complexes - imparts versatility on signalling

Jörg Gsponer, Univ. of  British Columbia
Disorder in protein switches

Scott A. Showalter, The Pennsylvania State Univ.
Assessing Intrinsically Disordered Protein Structure and Function through Carbon Detected NMR

Targeting Disorder with Small Molecules

Wednesday, April 1, 2015, 9:00 AM - 11:15 AM
Room 258C

Session Chair: Scott Showalter, The Pennsylvania State Univ.    

Invited Speakers:

Carlos J. Camacho, Univ. of Pittsburgh
On modulating the regulatory role of intrinsically disordered proteins using small molecules

Steven J. Metallo, Georgetown Univ.
Specificity and Promiscuity in Small Molecule Binding to Intrinsically Disordered Protein Regions

Sheena E. Radford, Univ. of Leeds
Biophysical Studies of Amyloid Formation and Its Inhibition