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Extracellular Matricies in Health and Disease

Abstract deadline extended to Monday, November 10 at 5PM, EST

Theme organizers:


Jeffrey Gorski
Univ. of
Missouri-Kansas City


Karen Lyons

This theme is made up of four symposia, one scheduled each day of the meeting, Sun – Wed.  Please read below for invited speaker and session schedule information.  In addition to the invited talks listed below, short talks will be selected from the submitted abstracts.  To be considered for a volunteered talk in this theme, submit your abstract to an ASBMB topic category number: 2180-2193, by the November 6th submission deadline.  All volunteered abstracts will be programmed for poster presentation.  Those selected for oral presentation will also present a poster.  Programming notifications will be sent in mid-January.  We look forward to seeing you at the Boston Convention and Exhibition Center, BCEC, March 28 – April 1, 2015.

Interactions of Growth Factors and Integrins with the Extracellular Matrix

Sunday, March 29, 2015, 9:45 AM - 12:00 PM
Room 257A/B

Invited Speakers:

Reinhard Fässler, Max Planck Inst. of Biochemistry
Integrins cooperate during mechanosensing

Jeffrey  A. Hubbell, Univ. of Chicago and Ecole Polytechnique Fédérale de Lausanne (EPFL)
Engineering interactions between growth factors and the extracellular matrix

Karen M. Lyons, UCLA
Members of the CCN Family of Matricellular Proteins are Required for the Formation and Maintenance of Multiple Skeletal Tissues

Effects of Enzymatic Modification of Extracellular Matrix Proteins

Monday, March 30, 2015, 3:55 PM - 6:10 PM
Room 257A/B

Invited Speakers:

Xi He, Boston Children's Hosp. and Harvard Med. Sch.
Wnt modification by Tiki proteins

Nabil G. Seidah, Clinical Res. Inst. of Montreal (IRCM)
The proprotein convertases and extracellular matrix remodeling

Zena Werb, UCSF
MMPs as regulators of tumor microenvironment

Regulation of Stem Cell Niches by the Extracellular Matrix

Tuesday, March 31, 2015, 9:45 AM - 12:00 PM
Room 257A/B

Invited Speakers:

George E. Davis, Univ. of Missouri Sch. Of Med.
ECM remodeling events during EC-pericyte tube co-assembly in 3D matrices

Songtao Shi, USC (U Penn, Nov 2014)
Mesenchymal stem cells: diseases and cure

Steve Weiss, Univ. of Michigan
Proteolytic Remodeling of the 3D Extracellular Matrix Controls the Nuclear Regulation of Mesenchymal Stem Cell Fate and Function

Function of the Extracellular Matrix in Development and Disease 
This session is jointly sponsored by ASBMB and AAA 

Wednesday, April 1, 2015, 1:15 PM - 3:30 PM
Room 257A/B

Invited Speakers:

Peter H. Byers, Univ. of Washington
Recessive forms of osteogenesis imperfecta (OI) and implications for mechanisms of disease

Jeffrey P. Gorski, Univ. of Missouri-Kansas City
Crosstalk between bone and muscle: deletion of Mbtps1 in bone leads to age-dependent increase in muscle size and contractile function

Ralph Marcucio, UCSF
Mechanisms of FGF-mediated morphogenesis