ASBMB Nobel Prize Winners

2007 - Mario Renato Capecchi


2007 Capecchi

Mario R. Capecchi received one-third of the 2007 Nobel Prize in Physiology or Medicine for his work in gene targeting in mice, a technique that has revolutionized mammalian biology and allowed the creation of animal models for hundreds of human diseases. Capecchi’s work in this field started when he succeeded in using extremely small glass needles to introduce a functional gene into cells by injecting DNA directly into their nuclei. After modifying this technique, he was able to use it to introduce short sequences of manipulated DNA into the chromosomes of mammalian cells. These experiments showed that homologous recombination could take place between introduced DNA and the chromosomes in mammalian cell and could even be used to repair defective genes.