ASBMB Nobel Prize Winners

1972 - William H. Stein



William Howard Stein (1911 – 1980) was awarded the Nobel Prize in Chemistry in 1972 with Christian B. Anfinsen and Stanford Moore for their work on ribonuclease, an enzyme that catalyzes the breakdown of RNA into smaller components, especially how its chemical structure and catalytic activity are related. With Moore, who was his colleague at the Rockefeller Institute in New York, Stein developed methods to analyze amino acids and peptides obtained from proteins. They then applied those procedures to determine the structure of ribonuclease. The same year they were awarded the Nobel Prize, Stein and Moore described the complete sequence of deoxyribonuclease, an enzyme that catalyzes the breakdown of DNA and is twice as complex as ribonuclease.