ASBMB Nobel Prize Winners

1970 Luis F. Leloir

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Leloir

Luis Federico Leloir (1906-1987) was awarded the 1970 Nobel Prize in Chemistry for his discovery of sugar nucleotides and their role in the biosynthesis of carbohydrates. With his colleagues, Leloir isolated glucose 1,6-diphosphate and uridine diphosphate glucose (a sugar nucleotide). Uridine diphosphate glucose was found to act as a glucose donor in the synthesis of trehalose (a sugar produced by fungi, plants, and invertebrates) and sucrose. Later, Leloir showed that uridine diphosphate glucose is involved in the synthesis of glycogen and adenosine diphosphate glucose in the synthesis of starch.