Malcolm Daniel Lane was born in Chicago, Illinois. He received both his B.S. and M.S. from Iowa State University, in 1951 and 1953, respectively. Lane then went to the University of Illinois for graduate school and was awarded a Ph.D. in 1956. After that, he joined the faculty of the Virginia Polytechnic Institute and State University in Blacksburg, Virginia, as an associate professor, and was promoted to professor of biochemistry in 1963. Lane became associate professor of biochemistry at the New York University School of Medicine in 1964 and professor of biochemistry in 1969. He left New York in 1970 to become professor of biological chemistry at the Johns Hopkins University School of Medicine and was eventually promoted to director and DeLamar Professor in 1978.He is currently Distinguished Service Professor in the Department of Biological Chemistry at Johns Hopkins.
The primary focus of Lane's research is on understanding the basic mechanisms of fatty acid synthesis, adipogenesis, and the consequence of aberrations in these processes, most notably obesity. His work in molecular mechanisms responsible for the development of adipose tissue in mammals forms the basis for the understanding of the differentiation of this tissue. Lane has also made important contributions to the study of insulin signaling and mechanisms underlying diabetes. Some of Lane's research was featured as a Journal of Biological Chemistry Classic (1).
In addition to serving as president of the American Society for Biochemistry and Molecular Biology in 1990, Lane served on the Society's Program Committee, Membership Committee, and Public Affairs Committee. He was elected to the American Academy of Arts and Sciences in 1982, the American Society for Nutritional Sciences in 1996, and the National Academy of Sciences in 1987. Lane was awarded the American Institute of Nutrition Mead Johnson Award 1966, the American Society of Biological Chemists William C. Rose Award in 1981, and the Johns Hopkins University School of Medicine Professor's Award for Distinction in Teaching in 1986. He has served on the editorial boards of several journals, including those of the Journal of Biological Chemistry, Biochemica et Biophysica Acta, Archives of Biochemistry and Biophysics, and Annual Reviews of Biochemistry. He also served on the editorial board and was executive editor of Biochemical and Biophysical Research Communications in 1986.
1. Kresge, N., Simoni, R. D., and Hill, R. L. (2006) Acetyl-CoA carboxylase and other biotin-dependent enzymes: The work of M. Daniel Lane. J. Biol. Chem. 281 (49)