Henry Arnold Lardy was president of the American Society of Biological Chemists in 1964.He was born in Roslyn, South Dakota, and earned his bachelor's degree in 1939 from South Dakota State University, double majoring in chemistry and dairy science. He received both his M.S. (1940) and his Ph.D. (1945) in biochemistry from the University of Wisconsin-Madison and remained there, serving as chair of a section of the Enzyme Institute, from 1950 until his retirement in 1988.
Lardy's research at Wisconsin covered a wide variety of metabolic phenomena, including the regeneration of phosphopyruvate during glycogen synthesis, the inhibition of glycolysis by glyceraldehyde, and the role of phosphate acceptors in controlling oxidation rates in metabolism. This research was described in a Journal of Biological Chemistry Classic (1). In addition to the above areas of metabolic research, Lardy pioneered work on the preservation and storage of semen, which has made artificial insemination in livestock practical; discovered a treatment for selenium poisoning in livestock; and found that the function of biotin was to fix CO2 in heterotrophic organisms. Currently, his research focuses on dehydroepiandrosterone (DHEA) and its metabolites.
Lardy has authored more than 370 publications in major journals and books and has received numerous awards, including the American Chemical Society's Paul Lewis Award in Enzyme Chemistry (1949), the Wolf Foundation Award in Agriculture (1981), the National Award of Agricultural Excellence (1982), and the American Society of Biological Chemists William C. Rose Award (1988). In addition to being president of the American Society of Biological Chemists, Lardy was a member of the Journal of Biological Chemistry editorial board from 1958 to 1964 and 1980 to 1985. He has been a member of the National Academy of Sciences since 1958.
1. Kresge, N., Simoni, R. D., and Hill, R. L. (2005) Henry Lardy's contributions to understanding the metabolic pathway. J. Biol. Chem. 280 (20)