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Biochemistry and Cell Biology of ESCRTs in Health and Disease

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Drs. James Hurley and Phyllis Hanson

LOCATION: Snowbird Resort and Conference Center, Snowbird, Utah
DATE: Oct. 14 - Oct. 17, 2010

: James Hurley, National Institute of Diabetes and Digestive and Kidney Diseases
Phyllis Hanson, Washington University School of Medicine in St. Louis

EXTENDED to October 1, 2010 -- Webcast Registration Deadline 
Sept. 10, 2010 -- Registration Deadline and Final Abstract Submissions Deadline
July 30, 2010 -- Early Registration Deadline ($100 Savings) and Short Talk Abstract Deadline

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Meeting Summary

This meeting is supported by generous contributions from:

Avanti Polar Lipids Logo EMBO Young Investigator

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NHLBI Web Logo

NIAID Web Logo

NIDDK Web Logo NINDS Web Logo OAR Web Logo (OD)

The ESCRT system is a conserved pathway for membrane budding and scission with roles in endolysosomal sorting and receptor downregulation, autophagy, the egress of enveloped viruses including HIV-1, and in cell division. With their ability to cut membrane necks from the inside, the ESCRTs are one of the most remarkable and mysterious membrane remodeling machineries known. ESCRT research has been central to the endosome-to-lysosome sorting field since the discovery and naming of the ESCRTs by Emr and colleagues almost a decade ago. More recently, ESCRT research has become important, and even central, to a number of other areas of biology and medicine. Understanding ESCRT function has taken on increasing importance in understanding the budding of enveloped viruses from cells. Even more recently, defects in the ESCRT pathway have been implicated in neurological diseases. Thus, this short conference will span ESCRT-ology from basic biophysical and structural mechanisms all the way to the clinic.

Despite their expanding numbers, the North American community of ESCRT researchers has never had a focused conference dedicated to this topic. Worldwide, there has been only one symposium, a two-day conference organized by the U.K. Biochemical Society and held in Cambridge in 2008. That meeting helped crystallize and define the questions in the field.

Polling of the field within the U.S. and Canada made clear that there was a strong desire to sustain the momentum built at that meeting and to involve greater numbers of younger North American researchers. This fall’s ASBMB-sponsored meeting will fill this niche and be a must-attend event for endolysosomal trafficking specialists; structural biologists and membrane biophysicists interested in ESCRT mechanism; and cell biologists, virologists, and clinical researchers interested in cell division, autophagy, viral budding, and neurological diseases. To see the list of meeting speakers and presenation topic areas, please explore the program.