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Program

Draft Agenda
Last Updated: September 20, 2010


Thursday, October 14th 

 4:00 p.m. - 7:30 p.m. Arrival and Registration 

6:00 p.m. – 7:30 p.m. Networking and Lite Refreshments

7:30 p.m. – 7:40 p.m. Organizer Welcome
                                     
 Phyllis Hanson, Washington University School of Medicine
                                                  James Hurley, National Institute of Diabetes and Digestive and 
                                      Kidney Diseases, NIH
                                     
7:40 p.m. – 8:30 p.m. Keynote: Anatomy of cytokinetic membrane abscission by ESCRTs
                                      Jennifer Lippincott-Schwartz, National Institute of Child 
                                      Health and Human Development, NIH

8:30 p.m. – 11:00 p.m. Opening Reception Hosted by ASBMB
                                        
 (Will include Cocktails and Dinner Buffet)


Friday, October 15th

7:00 a.m. – 8:30 a.m.  Breakfast

8:30 a.m. – 10:50 a.m. Session 1: ESCRT Structure and Mechanism
    
 8:30 – 8:35 a.m. Session Overview
                               David Katzmann, Mayo Clinic
 
 8:35 – 9:05 a.m. Structural and Functional Analyses of ALIX Interactions with Retrovirus 
                              Gag and Host CHMP4 Proteins                               
                               Chris Hill, University of Utah

 9:05 – 9:35 a.m.  ESCRT-III filaments: spiraling toward membrane scission?
                                Phyllis Hanson, Washington University School of Medicine

 9:35 – 9:50 a.m. Coatless vesicle budding into endosomes by ESCRT complexes
                               Bartosz Rozycki, NIDDK, National Institutes of Health

 9:50 – 10:05 a.m. Characterization of ESCRT-III disassembly by Vps4
                                 Brian Davies, Mayo Clinic

 10:05 – 10:20 a.m. Structural Basis of Vps4 Activation by the Vta1-Vps60 Complex
                                   Zhaohui Xu, University of Michigan

 10:20 – 10:35 a.m. Biochemical and Structural Analyses of the Lip5 – Chmp5 Complex
                                   Jack Skalicky, University of Utah

 10:35 – 10:50 a.m. Penta-EF-hand protein ALG-2 functions as a Ca2+- dependent
                                   adaptor that bridges ALIX and ESCRT-I
                                   Mayumi Okumura, Nagoya University Graduate School of Bioagricultural Sciences

10:50 a.m. – 11:10 a.m. Coffee Break

11:10 a.m. – 12:45 p.m. Session 2: Multivesicular Bodies and Ubiquitinated Cargo Sorting

 11:10 – 11:15 a.m. Session Overview
                                   Lois Weisman, University of Michigan

 11:15 – 11:45 a.m. The hitchhiker's guide to class E compartments
                                   Greg Odorizzi, University of Colorado

 11:45 – 12:15 p.m. A single ubiquitin is sufficient for cargo protein entry into MVBs in the 
                                  absence of ESCRT ubiquitination
                                  Robert Piper, University of Iowa

 12:15 – 12:30 p.m. Interplay between tetraspanin- and ESCRT-mediated sorting during
                                   physiological amyloidogenesies and the biogenesis of Lysosome 
                                   related organelles
                                   Guillaume van Niel, Curie Institute

 12:30 – 12:45 p.m. Multiple roles for ESCRT-0 in cargo recognition and MVE dynamics
                                   Anjon Audhya, University of Wisconsin-Madison

12:45 p.m. – 3:30 p.m. Lunch and Free Time

3:30 p.m. – 6:00 p.m.  Session 3: HIV and Other Viruses

 3:30 – 3:35 p.m. Session Overview
                               Heinrich Gottlinger, UMass Medical School

 3:35 – 4:05 p.m. The Late Domain "Proteome": Cellular Proteins Associated with
                               Membrane-Bound HIV-1 Gag in a Late Domain- Dependent Manner
                               Carol Carter, SUNY - Stony Brook

 4:05 – 4:35 p.m. Host Cell Machinery in HIV-1 Assembly and Budding
                              Eric Freed, NCI-Frederick

 4:35 – 4:50 p.m. Basic residues in the Nucleocapsid domain of Gag are critical for
                               late events of HIV-1 budding
                               Fadila Bouamr, NIAID, NIH

 4:50 – 5:05 p.m. Requirements for Ubiquitin Ligase-Stimulated HIV-1 Release
                              Eric Weiss, UMass Medical School

 5:05 – 5:20 p.m. Dynamics of HIV Budding Site Interactions with Vps4a Visualized
                               by Live-cell Imaging
                               Viola Baumgaertel, Ludwig-Maximilians University Munich

 5:20 – 5:35 p.m. Dynamics of ESCRT protein recruitment during retroviral assembly
                               Nolwenn Jouvenet, ADARC

 5:35 – 5:50 p.m. Influenza virus budding: who needs an ESCRT when there is M2
                              Jeremy Rossman, Northwestern University

6:00 p.m. – 7:45 p.m. Dinner

8:00 p.m. – 10:00 p.m. Poster Session
    

Saturday, October 16th

7:00 a.m. – 8:30 a.m. Breakfast

8:30 a.m. – 10:40 a.m. Session 4: Cell Division and Development

 8:30 – 8:35 a.m. Session Overview
                              Wesley Sundquist, University of Utah School of Medicine

 8:35 – 9:05 a.m. Plant-specific functions of Arabidopsis SKD1-interacting proteins
                              Marisa Otegui, University of Wisconsin-Madison

 9:05 – 9:35 a.m. Roles of the ESCRT machinery in cellular processes and retroviral release
                              Juan Martin-Serrano, King's College London

 9:35 – 9:50 a.m. Roles of ESCRT-III/VPS4 proteins in mitosis
                              Leremy Colf, University of Utah

 9:50 – 10:05 a.m. Mechanism of cytokinetic abscission
                                Julien Guizetti, ETH Zurich

 10:05 – 10:20 a.m. Exploring roles for ESCRT machinery in budding yeast cytokinesis
                                   Michael McMurray, UC Berkeley
 
 10:20 – 10:35 a.m. ESCRT II is necessary for the trapping of RNA to membranes in
                                   Xenopus laevis
                                   Joshua Plant, Harvard Medical School

10:40 a.m. – 11:00 a.m. Coffee Break
    
11:00 a.m. – 12:50 p.m. Session 5: Receptor Downregulation and Cell Physiology

 11:00 – 11:05 a.m. Session Overview
                                   Mark von Zastrow, UCSF

 11:05 – 11:35 a.m. Regulatory connection between translation initiation and ESCRT function
                                   Markus Babst, University of Utah

 11:35 – 12:05 p.m. Endoosmal sorting of receptors and transporters: role of ubiquitination
                                   Alexander Sorkin, University of Pittsburgh

 12:05 – 12:20 p.m. ALIX and CHMP4C Regulate GPCR Lysosomal Sorting Independent
                                  of Ubiquitination and Ubiquitin-binding ESCRTs
                                  Michael Dores, University of California, San Diego

 12:20 – 12:35 p.m. Arrestin-2 Interacts with the ESCRT Machinery to Modulate Endosomal
                                   Sorting of CXCR4
                                   Rohit Malik, Loyola University Chicago

 12:35 – 12:50 p.m. Ultrastructure of the T cell immunological synapse reveals the cellular basis 
                                   for supramolecular domain organization
                                   Kaushik Choudhuri, NYU School of Medicine

12:50 p.m. – 2:00 p.m. Lunch on Your Own

3:30 p.m. - 4:25 p.m.   Business and ESCRT Nomenclature Meeting 
   
4:25 p.m. – 6:00 p.m. Session 6: Neurodegenerative Diseases
    
 4:25 – 4:30 p.m. Session Overview
                              Scott Emr, Cornell University

 4:30 – 5:00 p.m. ESCRT Proteins in the Pathogenesis of Hereditary Spastic Paraplegias
                              Craig Blackstone, NINDS, NIH

 5:00 – 5:30 p.m. Mutations in the ESCRT-III component CHMP2B impair endosomal fusion
                              events and cause frontotemporal dementia
                              Adrian Isaacs, UCL Institute of Neurology

 5:30 – 5:45 p.m. Novel ESCRT regulators and neurodegenerative disease
                              Lian Li, Emory University School of Medicine

 5:45 – 6:00 p.m. Inducible inactivation of the ESCRT-I gene Tsg101 causes neurodegeneration
                              in adult mice
                              Will Walker, McLaughlin Research Institute

6:00 p.m. – 7:45 p.m. Dinner

8:00 p.m. – 10:00 p.m. Poster Session

Sunday, October 17th

7:00 a.m. – 8:30 a.m. Breakfast and Departures (Hotel check out is 11:00 a.m.)