Dr. Matthews received his B.S. from the University of Minnesota in 1968. He then received his M.S. (in 1969) and Ph.D. (1974) degrees at Stanford University, and completed a brief post-doctoral fellowship before being named professor of chemistry at The Pennsylvania State University in 1975. In 2000, he was appointed the Arthur F. and Helen P. Koskinas Professor of Biochemistry and Molecular Phamacology at the University of Massachusettes School of Medicine.
The goals of his research lab are to obtain a molecular-level understanding of the folding mechanisms of several very common motifs, and to use those insights to contribute to the development of a general theory of protein folding. More recently, his lab has become interested in applying these biophysical insights to the development of therapeutics for misfolding diseases.
Matthews Lab website