9th-12th Grade HOPES Activity Manuals

9-12 In Sickness and In Health: Understanding Familial Disease
Inheritance and Personalized Medicine Through Genomics.

 
This activity series focuses on the central dogma of molecular biology to consider the concept of health and disease from the DNA level. Students will conduct an interactive case study of a disease-causing genetic mutation, use Legos to illustrate transcription/ translation and create an original piece of art that depicts an interviewed scientist’s research. Activity courtesy of HOPES 2013 Recipients Dr. Nicholas Schork, Danjuma Quarless, Scientists & Matthew Leader, Teacher.

HOPES ACTIVITY MANUAL 

Additional Resources:
Lego Activity- Student Guide   Lego Activity- Teacher Guide 

 

9-12 Genes, Mutations and Diseases: Understanding the Origins
of Genetic Disorders through Experiential Learning.
Lesson 1 Nucleotides, Nucleic Acids, DNA and Genes.  

 
Part of a five lesson unit, lesson one walks students, step-by-step, through an overview of genetics, from the basics of DNA all the way up through the science behind genetic disorders. Sickle cell anemia is used as an example throughout the module to demonstrate the connections between genes, mutations and disease. Lesson can be used individually or part of a unit. Activity courtesy of HOPES 2013 Recipients Dr. Edwin Li, Dr. Brian Forster, and Caitlin Fritz, Scientists and Matthew Jurkiewicz, Teacher.

HOPES ACTIVITY MANUAL 

Additional Resources:
Worksheet Manual- Student and Teacher 
Lecture Material- Lesson 1

 

9-12 Genes, Mutations and Diseases: Understanding the Origins
of Genetic Disorders through Experiential Learning.
 
 
Lesson 2 Transcription, Translation and Mutations 

 
Part of a five lesson unit, lesson two continues looking at DNA to answer, how are genes expressed? DNA is first transcribed into RNA then translated into proteins. Mutations in DNA may alter the protein, which can have large impacts on structure and function, evidenced here by red blood cells in sickle cell anemia. Lesson can be used individually or part of a unit. Activity courtesy of HOPES 2013 Recipients Dr. Edwin Li, Dr. Brian Forster, and Caitlin Fritz, Scientists and Matthew Jurkiewicz, Teacher.

HOPES ACTIVITY MANUAL 

Additional Resources:
Worksheet Manual- Student and Teacher 
Lecture Material- Lesson 2 

 

9-12 Genes, Mutations and Diseases: Understanding the Origins
of Genetic Disorders through Experiential Learning.
 
 
Lesson 3 Inheritance: Mitosis and Meiosis

 
Part of a five lesson unit, lesson three teaches the fundamentals of cell division through mitosis and meiosis via lecture, hands-on modeling and experimental observation. This activity teaches how the cell maintains proper chromosome number while it replicates, how parents are able to donate half their chromosomes to their offspring, and the relationship between chromosomes and genes. Lesson can be used individually or part of a unit. Activity courtesy of HOPES 2013 Recipients Dr. Edwin Li, Dr. Brian Forster, and Caitlin Fritz, Scientists and Matthew Jurkiewicz, Teacher.

HOPES ACTIVITY MANUAL 

Additional Resources:
Worksheet Manual- Student and Teacher 
Lecture Material- Lesson 3