Sept. 27, 2013 — The cover story of the October issue of ASBMB Today delves into what we know about protein evolution and explores the debate over whether function or structure first arose in primitive peptides. This month’s Derailed but Undeterred contribution by F. Peter Guengerich marks the end of the personal essay series. For job-seekers and new (or struggling) managers, we have two Career Insights articles: In the first one, seasoned lab managers offer their advice on how to run a research group; in the second, Bill Sullivan provides do’s and don’ts for postdoctoral application cover letters. Lastly, don’t forget to submit an open letter for our forthcoming series, Open Letters. The deadline is Dec. 31. Read the October issue.