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Mechanistic Impacts of Post-translation Modifications

Abstract deadline extended to Monday, November 10 at 5PM, EST

Theme organizers: 

          Philip Cole  Paul Thompson
 Philip Cole
Johns Hopkins School
Of Medicine
Paul R. Thompson
The Scripps Research

This theme is made up of four symposia, one scheduled each day of the meeting, Sun – Wed.  Please read below for invited speaker and session schedule information.  In addition to the invited talks listed below, short talks will be selected from the submitted abstracts.  To be considered for a volunteered talk in this theme, submit your abstract to an ASBMB topic category number: 2290-2299, by the November 6th submission deadline.  All volunteered abstracts will be programmed for poster presentation.  Those selected for oral presentation will also present a poster.  Programming notifications will be sent in mid-January.  We look forward to seeing you at the Boston Convention and Exhibition Center, BCEC, March 28 – April 1, 2015.

Post-translational Modifications of Lysine

Sunday, March 29, 2015, 3:55 PM - 6:10 PM
Room 258A

Session Chair: Paul R. Thompson, The Scripps Res. Inst.

Invited Speakers:

Philip Cole, Johns Hopkins Sch. Of Med.
Targeting reversible lysine modifications

Robert A. Copeland, Epizyme, Inc.
Protein Methyltransferase Inhibitors as Cancer Therapeutics

Dirk Schwarzer, Univ. of Tuebingen
A chemical toolbox for lysine deacetylases

Post-translational Modifications of Arginine:  Methylation, Citrullination, Phosphorylation

Monday, March 30, 2015, 9:45 AM - 12:00 PM
Room 258A

Session Chair: Philip Cole, Johns Hopkins Sch. Of Med.

Invited Speakers:

Tim Clausen, Inst. of Molecular Pathology - IMP, Vienna
No stress with pArg? About the biological role of protein arginine phosphorylation

Danica Galonic Fujimori, UCSF
Positive Feedback Regulation in Histone Demethylases

Paul R. Thompson, The Scripps Res. Inst.
Picking the PADlock:  Chemical probes to study the protein arginine deiminases

Post-translational Modifications of Cysteine: Lipidation and Oxidation

Tuesday, March 31, 2015, 3:55 PM - 6:10 PM
Room 258A

Session Chair: Gerald W. Hart, Johns Hopkins Univ. Sch. Of Med.

Invited Speakers:

Maurine Linder, Cornell Univ.
Mechanism and Function of DHHC Palmitoyltransferases

Brent Martin, Univ. of Michigan
Rescuing cell polarity with small molecule inhibitors of de-palmitoylation

Eranthie Weerapana, Boston Col.
A chemical-proteomic platform to investigate cysteine S-nitrosation

O-GlcNAcylatoin: How Sweet It Is

Wednesday, April 1, 2015, 9:00 AM - 11:15 AM
Room 258A

Session Chair: Eranthie Weerapana, Boston Col.

Invited Speakers:

Donald Bers, UC, Davis
O-GlcNAcylation of CaMKII in Cardiac Myocytes can be Pro-Arrhythmic

Gerald W. Hart, Johns Hopkins Univ. Sch. Of Med.
Nutrient Regulation of Signaling & Transcription by O-GlcNAcylation

Suzanne Walker, Harvard Med. Sch.
The Split Personality of Human O-GlcNAc Transferase