Lipids - In Vivo Dynamics, Protein Partners and Signaling

Theme organizers:

Michael Best
Univ. of Tennessee
at Knoxville
  Wonhwa Cho
Univ. of Illinois
at Chicago

Multitalented Lipids    

Sunday, March 29, 2015, 9:45 AM - 12:00 PM • Room 252A/B

Follow the conversation: #lipids

Chaired: W. Cho

9:45                        Chair’s Introduction.

9:50      90.1          Phosphoinositide Signaling in the Control of Membrane Dynamics and Interactions P. De Camilli. Yale Univ., HHMI.

10:15                      Investigating the Role of Cellular Lipid Recognition in Trafficking and Viral Particle Formation by Ebola Virus Matrix Protein VP40 K.A. Johnson and R.V. Stahelin. Univ. of Notre Dame and Indiana Univ. Sch. of Med., South Bend. (886.6)

10:30    90.2          Transcriptional Regulation by Nuclear Phosphoinositides Y. Stijf-Bultsma, L. Somer, M. Tauber, P. Giardoglou, D.R. Jones, K.A. Gelato, M. Baalbaki, D. Hart, S.M. Lauberth, A-P.G. Haramis, W. Fischle and N. Divecha. Univ. of Southampton, U.K.

10:55                      Phosphoinositide Binding to ErbB3-Binding Protein 1 Contributes to Its Nucleolar Localization A.E. Lewis, T. Karlsson and A. Altankhuyag. Univ. of Bergen. (715.25)

11:10                      The Lipid Transfer Protein STARD3: An Architect from Inside the Cell C.L. Tomasetto, F. Alpy, G. Drin and T.P. Levine. IGBMC- U964 INSERM, Strasbourg, University Col. London and Univ. of Nice Sophia-Antipolis. (568.1)

11:25    90.3          Hedgehogs and Lipids A. Salic. Harvard Med. Sch.

11:50                      Discussion. 

Lipids Meet Chemistry    

Monday, March 30, 2015, 3:55 PM - 6:10 PM • Room 252A/B 

Follow the conversation: #lipids

 Chaired: C. Schultz

3:55                        Chair’s Introduction.

4:00      234.1       Chemical Approaches to the Identification and Characterization of Protein-Membrane Binding Interactions Using Synthetic Lipid Probes M. Best, M.M. Rowland, T. Ricks, S. Alam, S. Eni Eni and S. Mattern-Schain. Univ. of Tennessee, Knoxville.

4:25                        Targeting Plasmodium falciparum Phosphethanolamine Methyltransferase for Malaria Therapy C. Ben Mamoun and V. Kumar. Yale Univ. (885.25)

4:40      234.2       Membrane Lipids in Migrating Cells Illuminated by Molecular Sensors and Chemical Actuators T. Inoue, Y. Miao and P. Devreotes. Johns Hopkins Univ.

5:05                        Specific Transient Interactions between a Bacillus Virulence Factor and Phosphatidylcholine in Membranes A. Gershenson, B. Yang, T. He, H.M. Khan, C. Grauffel, N. Reuter and M.F. Roberts. Univ. of Massachusetts Amherst, Boston Col. and Univ. of Bergen. (568.9)

5:20                        Role of Macroautophagy in Anti-cancer Effects of the Novel Sphingolipid, Enigmol S.G. Mays, A.S. Bushnev, M.T. Baillie, H. Yi, D.C. Liotta and J.A. Petros. Emory Univ. and Atlanta VA Med. Ctr. (715.42)

5:35      234.3       Compartmentalized PI3K/Akt/mTOR Signaling in Living Cells J. Zhang. Johns Hopkins Univ. Sch. of Med.

6:00                        Discussion.

Lipids Caught in Action    

Tuesday, March 31, 2015, 9:45 AM - 12:00 PM • Room 252A/B

Follow the conversation: #lipids

Chaired: A. Salic

9:45                        Chair’s Introduction.

9:50      357.1       Following Lipid Signaling in Intact Cells C. Schultz. European Molec. Biol. Lab., Heidelberg.

10:15                      Phosphatidylinositol 4-Phosphate Dynamics during Phagocytosis R. Levin, G.R.V. Hammond, T. Balla, G.D. Fairn and S. Grinstein. Hosp. for Sick Children, NICHD, NIH and St. Michael’s Hosp., Toronto. (568.17)

10:30    357.2       Imaging Cellular Protein Fatty Acylation R. Hannoush. Genentech.

10:55                      Does PtdIns(4,5)P2 Concentrate So It Can Multitask? G. Hammond and T. Balla. NICHD, NIH and Univ. of Pittsburgh Sch. of Med. (568.22)

11:10                      Perilipin 5 Mediated Lipid Droplet Remodelling Revealed by Coherent Raman Imaging N. Billecke, M. Bosma, W.T. Rock, P. Schrauwen, M. Bonn, M.K.C. Hesselink and S.H. Parekh. Max Planck Inst. for Polymer Res., Mainz, Maastricht Univ. Med. Ctr. and Karolinska Inst. (568.19)

11:25    357.3       A Cholesterol Story Never Told Before W. Cho, R. Sheng and S-L. Liu. Univ. of Illinois at Chicago.

11:50                      Discussion.

Chemical and Optogenetic Manipulation of Lipid Signaling Workshop

Sponsored by an education grant from Avanti Polar Lipids, Inc.

Tuesday, March 31, 2015, 12:30 PM - 2:00 PM • Room 251 

Follow the conversation: #lipids

 Workshop Presenters:

12:30    364.1       Optogenetic Manipulation of Phosphoinositides O. Idevall-Hagren. Uppsala Univ.

1:15      364.2       Recent Technological Advancement in Chemical Switching of Lipid Signaling Pathways T. Inoue and S. Phua. Johns Hopkins Univ.

Lipid Magic: How Do They Do It?               

Wednesday, April 1, 2015, 1:15 PM - 3:30 PM • Room 252A/B 

Follow the conversation: #lipids

Chaired: P. De Camill

1:15                        Chair’s Introduction.

1:20                        Award lecturer introduction and award presentation.

1:30                        From Lipidomics to Cellular Functions: Lipids as Modulators of Protein Activity B. Brügger. Heidelberg Univ. (492.1)

1:55      493.1       Membrane Proteins – the Lipid Connection C. Robinson. Univ. of Oxford.

2:20                        Biochemical Characterization of the Interaction between Hsp70s and Lipids B. Kdeiss, C. McCallister and N. Nikolaidis. California State Univ. Fullerton. (886.11)

2:35      493.2       Structural Mechanisms of PI3K and PTEN Regulation R. Williams, G.R. Masson, O. Vadas, J.E. Burke and O. Perisic. MRC Lab. of Molecul. Biol., Cambridge.

3:00      493.3       The Signaling Phospholipid PIP3 Functions as a Ligand Hormone for Nuclear Receptors H.A. Ingraham, R. Blind, E. Sablin, D. Das and R.J. Fletterick. UCSF and SLAC Natl. Accelerator Lab.

3:25                        Discussion.