• ASBMB 2016 Annual Meeting

DNA Replication, Repair, and Recombination

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Theme Organizers: James Berger, Johns Hopkins Sch. of Med., and Agata Smogorzewska, The Rockefeller Univ. 
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Sunday, April 3, 2016
San Diego Convention Center, Room 1B
4:00 pm - 6:15 pm
Replication: Alpha to Omega
Session Chair: Agata Smogorzewska, The Rockefeller Univ. 

4:00                         Chair’s Introduction.

4:05 111.1              Single-Molecule Studies of Eukaryotic DNA Replication. S.P. Bell,S. Ticau, L.J. Friedman, J. Gelles. MIT and Brandeis Univ.

4:30                         Flexible   Modes   of   Translocation    by   the Eukaryotic CMG Helicase Facilitate Removal or Bypass of DNA Blocks. L.D. Langston, M. O’Donnell. HHMI, Rockefeller Univ. (578.4)

4:45 111.2              Structural Mechanisms for Initiating  DNA Replication. J. Berger. Johns Hopkins Univ. Sch. of Med.

5:10                         Function  of  Cdc45  in  DNA  Replication  and in Response to Genotoxic Stress. A. DeBrot, C. Lancaster, M-A. Bjornsti. Univ. of Alabama at Birmingham and St Jude Children’s Res. Hosp. (798.2)

5:25                         Breaking     the     Fourth   Wall:    Quaternary Organizations Forge a Link to the Novel Non-enzymatic Function of RNR-α. Y. Aye. Cornell Univ. and Weill Cornell Med., Ithaca. (793.1)

5:40     111.3          Replisome  Disassembly  at  the  Termination  of Eukaryotic Replication Forks. A. Gambus. Univ. of Birmingham, U.K.

6:05                         Discussion.

Sunday, April 3, 2016
San Diego Convention Center, Room 6A
6:30 pm - 8:30 pm
CRISPR: Power and Challenges

Workshop Chair: Marcin Nowotny, Int'l. Inst. of Molecular and Cell Biology

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6:30      118.1     CRISPR-Cas9: Power and Challenges. E. Charpentier. Max Planck Inst. for Infect. Biol., Berlin, Helmholtz Ctr. for Infect. Res., Germany, Umeå Univ., Sweden and Hannover Med. Sch., Germany.

7:00      118.2     The  Asymmetric   Interaction   of   Cas9   with Target DNA Can Promote High Efficiency Homology-Directed Genome Editing. J.E. Corn, C.D. Richardson, J. Ray, G. Curie, M. DeWitt. Univ. of California, Berkeley.

7:30      118.3     Turning genes off and on with CRISPRi and CRISPRa” He will talk about CRISPR.  J. Weissman.UCSF/HHMI.

Monday, April 4, 2016
San Diego Convention Center, Room 1B
9:45 am - 12:00 pm
Regulation of Recombination

Session Chair: Caroline Kisker, Univ. of Wurzburg  

9:45                    Chair’s Introduction.

9:50     239.1     Regulation of Homologous Recombination: Robustness through Reversibility. W-D. Heyer. Univ. of California, Davis.

10:15                  A Genome Wide Screen to Identify Genes that Prevent the Accumulation of Mutations.  H. W. Hombauer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.  

10:30   239.2     Dissecting the  Role  of  the  Rad51  Paralogs during Double-Strand Break Repair. K. Bernstein, T.B. McClendon, M.R. Sullivan, S.K. Godin, W. Gaines, P. Sung, J. Yanowitz. Univ. of Pittsburgh Sch. of Med. and Yale Univ.

10:55                  Estrogen  Induces  RAD51C  Expression  and Localization to Sites of DNA Damage. M.K. Holz. Yeshiva Univ., NY. (799.1)

11:10                  Interactomic    and    Enzymatic  Analyses   of Distinct Affinity Isolated HumanRetrotransposon Intermediates. J. LaCava,K.R. Molloy, D. Fenyö, M.S. Taylor,B.T. Chait, J.D. Boeke, M.P. Rout. The Rockefeller Univ.,NYU Sch. of Med. and Massachusetts Gen. Hosp. (801.1)

11:25   239.3      The Role of Mammalian Polymerase Theta in  DNA Repair. A. Sfeir. NYU Sch. of Med.

11:50                      Discussion.

Tuesday, April 5, 2016
San Diego Convention Center, Room 1B
4:00 pm - 6:15 pm
Structural Insights into DNA Repair

Session Chair: Agnel Sfier, Skirball Inst./ NYU Sch. of Med. 

4:00                         Chair’s Introduction.

4:05       389.1        The  Double  Edged  Sword  of  DNA   Repair. C. Kisker, J. Kuper, C. Braun, A. Elias, G. Michels, A. Poterszman, J-M. Egly. Univ. of Würzburg, Germany and CNRS, Univ. of Strasbourg, France.

4:30                         Tripartite    DNA    Lesion    Recognition    and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair. F.M. Golebiowski, C-L. Li, Y. Onishi,N.L. Samara, K. Sugasawa, W. Yang. NIDDK, NIH, Inst. of Molec. Biol., Acad. Sinica, Taipei and Kobe Univ., Japan. (793.2)

4:45       389.2        Mechanism of Structure-Selective  Nucleases. M. Nowotny. Intl. Inst. of Molec. and Cell Biol., Warsaw.

5:10                         Base Excision Repair of Bulky   DNA Adducts Generated by the Antitumor Drug Yatakemycin. E.A. Mullins, R. Shi,Y. Igarashi, B.F. Eichman.Vanderbilt Univ. and Toyama Prefect. Univ. (791.2)

5:25                         Kinetic Mechanism for Binding and Flipping of Damaged Bases by DNA Repair Dealkylases. P. O’Brien. Univ. of Michigan. (574.2)

5:40  389.3             The  Replication  Machinery  Encoded  by  SCCmec and Related Mobile Genetic Elements.     P.A.  Rice, I. Mir-Sanchis, S. Boyle-Vavra, Y.Z. Pigli. Univ. of Chicago.

6:05                         Discussion.


Wednesday, April 6, 2016
San Diego Convention Center, Room 1B
9:45 am - 12:00 pm
Repair During DNA Replication
Session Chair: James Berger, Johns Hopkins Sch. of Med.
9:45                       Chair’s Introduction.

9:50      500.1       DNA  Repair  during  DNA   Replication.   D. Cortez. Vanderbilt Univ. Sch. of Med.

10:15                     Early  Replication  Stress  Leads to Abnormal Mitosis and Genome Rearrangement. S. Forsburg. Univ. of So. California. (793.4)

10:30    500.2      Molecular Mechanism of DNA  Interstrand  Crosslink Repair.A. Smogorzewska, M. Kottemann, B. Conti, S. Thongthip, K. Rickman, F. Lach. The Rockefeller Univ.

A  Nucleolar  Role  for  the  Fanconi    Anemia Pathway Protein,FANCI, in rDNATranscription. S.B. Sondalle,
S. Longerich, P. Sung, S.J. Baserga. Yale Univ. (1048.1)

11:10                     Multiple    Invasions-Induced    Chromosomal Rearrangements. A. Piazza, W-D. Heyer. Univ. of California, Davis. (576.2)

11:25     500.3     Chromatin Replication and Epigenome Maintenance. A. Groth. BRIC, Univ. ofCopenhagen.

11:50                     Discussion.