• ASBMB 2016 Annual Meeting

Chromatin Organization and Gene Regulation

Follow the conversation on Twitter: #chromatin 

Theme Organizers: Bing Ren, Univ. of California, San Diego and Joan W. Conaway, Stowers Inst. 
The most up-to-date program information, view abstracts and plan your itinerary, download the EB2016 app or view online here: http://app.core-apps.com/eb2016

Sunday, April 3, 2016
San Diego Convention Center, Room 1B
9:45 am - 12:00 pm
Nuclear Architecture and Chromatin Organization

Session Chair: Joan W. Conaway, Stowers Inst.

9:45                         Chair’s Introduction.

9:50  99.1               The  3D  Organization  of   the   Mammalian Genome. B. Ren. UCSD     

10:15                       Chromatin  Extrusion  Explains  Key  Features of Loop and Domain Formation in Wild-Type and Engineered Genomes. A. Sanborn, S. Rao, S-C. Huang, N. Durand, M. Huntley, A. Jewett, I. Bochkov,D. Chinnappan, A. Cutkosky, J. Li, K. Geeting, A. Gnirke, A. Melnikov, D. McKenna, E. Stamenova, E. Lander, E.L. Aiden. Baylor Col. of Med., Stanford Univ. Sch. of Med. and BroadInst. of MIT and Harvard. (588.1)

10:30   99.2            Long-Range   Gene   Regulation    in    the Context of Chromatin Domains. J. Dekker. Univ. of Massachusetts, Worcester.

10:55                       Enhancer    H3K4   Methyltransferase   MLL4 Controls Cell Fate Transition. K. Ge. NIDDK, NIH. (802.1)

11:10                        BRD4  Is  a  Histone   Acetyltransferase  That Evicts   Nucleosomes   from   Chromatin.   D.N. Ballachanda, C. Case-Borden, A. Gegonne, C.H. Hsu, Q. Chen, D. Meerzaman, A. Dey, K. Ozato,D. Singer. NCI, NIH, Bethesda and Rockville and NICHD, NIH. (802.5)

11:25    99.3           Complex  Multi-enhancer  Contacts  Captured  by Genome Architecture Mapping, a Novel Ligation-Free Approach. A. Pombo, R.A. Beagrie, A. Scialdone, M. Schueler, M. Chotalia, S.Q. Xie, D. Kraemer, I. de Santiago, J. Fraser, J. Dostie, L. Game, N. Dillon, P.A.W. Edwards, M. Nicodemi. Berlin Inst. for Med. Systs. Biol., Imperial Col. Sch. of Med., U.K., Univ. of Naples Federico II, McGill Univ. and Univ. of Cambridge.

11:50                       Discussion.

Sunday, April 3, 2016
San Diego Convention Center, Room 6A
6:30 pm - 8:30 pm
CRISPR: Power and Challenges

Workshop Chair: Marcin Nowotny, Int'l. Inst. of Molecular and Cell Biology

Follow the conversation on Twitter: #DNA

6:30      118.1     CRISPR-Cas9: Power and Challenges. E. Charpentier. Max Planck Inst. for Infect. Biol., Berlin, Helmholtz Ctr. for Infect. Res., Germany, Umeå Univ., Sweden and Hannover Med. Sch., Germany.

7:00      118.2     The  Asymmetric   Interaction   of   Cas9   with Target DNA Can Promote High Efficiency Homology-Directed Genome Editing. J.E. Corn, C.D. Richardson, J. Ray, G. Curie, M. DeWitt. Univ. of California, Berkeley.

7:30      118.3     Turning genes off and on with CRISPRi and CRISPRa” He will talk about CRISPR.  J. Weissman.UCSF/HHMI.


Monday, April 4, 2016
San Diego Convention Center, Room 1B
4:00 pm - 6:30 pm
Transcriptional Regulatory Mechanisms

Session Chair: Shannon Lauberth, Univ. of California, San Diego

4:00                     Chair’s Introduction.

4:05      252.1     Impeding  the  Formation  of  Transcription  Initiation Complex. J-M. Egly. IGBMC, CNRS, INSERM, Univ. of Strasbourg, Illkirch.

4:30                     Mechanistic Study of  ERCC6/CSB Enzymatic Regulation, and Its Roles in Transcription Elongation, and Chromatin Remodeling. D. Wang. UCSD. (803.8)

4:45     252.2      Transcription and the Maintenance of Genome Stability.   J.Q.   Svejstrup,   L.  Williamson,   M.  Saponaro, S. Boeing, R. Mitter, G. Kelly. The Francis Crick Inst., South Mimms and London,U.K

5:10                     Steroid    Receptors    Can    Activate    Unique FoxA1 Binding Patterns through a Highly Dynamic Mechanism Associated with a Fast DNA ResidenceTime. E.E. Swinstead, T.B. Miranda, V. Paakinaho, S. Baek, M. Hawkins,T. Karpova, D. Ball, D. Mazza, L.D. Lavis, T. Morisaki, L. Grøntved, D.M. Presman, G.L. Hager. NCI, NIH, Univ. Vita Salute San Raffaele, Milan, HHMI, Ashburn, VA and Univ. of So. Denmark. (585.5)

5:25                      DNA Breaks and Damage Response SignalingAre Coupled with RNA Polymerase II Promoter-Proximal Pause Release and Required for Effective Transcriptional Elongation. H. Bunch. Harvard Med. Sch., Beth Israel Deaconess Med. Ctr. (589.1)

5:40     252.3       Elongin and the Elongin A Ubiquitin  Ligase  Complex in Transcription and the Response to DNA Damage. J.W. Conaway, J.C. Weems, B.D. Slaughter, J.R. Unruh, R.C. Conaway. Stowers Inst. for Med. Res. and Univ. of Kansas Med. Sch.

6:05                      Discussion.


Tuesday, April 5, 2016
San Diego Convention Center, Room 1B
9:45 am - 12:00 pm
Chromatin Remodeling and Epigenetics

Session Chair: Bing Ren, Univ. of California, San Diego, LICR

9:45                      Chair’s Introduction.

9:50      379.1      Reversible  RNA  Methylation  in  Gene   Expression Regulation. C. He. Univ. of Chicago and HHMI.

10:15                    Chromatin  Remodeler  EP400 Deposits H3.3 Into Promoters and Enhancers during Gene Activation. S.K. Pradhan, T. Su, L. Yen, K. Jacquet,J. Cote, S. Kurdistani, M. Carey. UCLAand LavalUniv. Cancer Res. Ctr.,Quebec. (803.9)
10:30   379.2       Mechanism   and   Regulation   of    the   SWI/ SNF Family of ATP-Dependent Chromatin Remodelers. B. Bartholomew, P. Sen, S. Kundu, S. Hailu, J.Persinger, A. Hada, Y. Lu, J. Luo, J. Ranish. MD Anderson, Smithville, Univ.
of Pennsylvania and Univ. of Washington.

10:55                    Epigenetics Impacts Copy Number Heterogeneity and Drug Resistant Gene Selection. J.R. Whetstine, J.C.  Black, S. Mishra, B. Sexton, C. Van Rechem, S. Murphy. MGH Cancer Ctr. and Harvard Med. Sch., Charlestown. (802.10)

11:10                    Structural       Basis       for     Histone      H2B Deubiquitination  by  the  SAGA  DUB  Module.  M.T. Morgan, M. Haj-Yahya, A.E. Ringel, P. Bandi, A. Brik, C. Wolberger. Johns Hopkins Med. Inst., Ben Gurion Univ. of the Negev and Technion-Israel Inst. of Technol. (803.14)

11:25     379.3     Structural and Functional Analysis of Histone Chaperones. Y. Gu, S. Bergeron, D. Krzizike, K. Luger. Univ. of Colorado at Boulder.

11:50                     Discussion.


Wednesday, April 6, 2016
San Diego Convention Center, Room 1B
2:15 pm - 4:30 pm
Non-coding RNA and Gene Regulation
Session Chair: Jesper Q. Svejstrup, Cancer Res. UK

2:15                         Chair’s Introduction.

2:20      507.1        Genome  Regulation   by   Long   Noncoding  RNAs. H.Y. Chang. Stanford Univ. Sch. of Med.

2:45                         Transfer  RNA  Fragments:  A  Novel Class of Non-micro Short RNAs That Uses Ago1, 3 and 4 to Repress Specific Target RNAs through 5’ Seed Sequences. A. Dutta, P. Kumar, M. Kiran, C. Kuscu. Univ. of Virginia. (1054.5)

3:00       507.2        The   Primary   Target    of   Let-7   MicroRNA. A.  Pasquinelli. UCSD.

3:25                         A   Specialized    Mechanism   of   MicroRNA- Mediated Translation in Quiescence. S. Vasudevan, S.I.A. Bukhari, S.S. Truesdell, S. Lee, S. Kollu, A. Classon, M. Boukhali, E. Jain, A. Yanagiya, R. Sadyrev, W. Haas. MGH- Harvard Med. Sch. and McGill Univ. (1054.6)

3:40                         NURF Localizes in Gene Bodies   to Regulate mRNA Processing. J. Landry, A. Alhazmi, M. Mack, A. Petencin, H. Nelson,J. Hiegel, V. Koparde,N. Scarsdale, C. Lyons, M. Dozmorov. Virginia Commonwealth Univ. (1053.1)

3:55      507.3         Enhancer   Transcription   and   Enhancer Function. C. Glass, D. Gosselin, V. Link, C.E. Romanoski, T. Troutman, M. Lam, D. Eichenfeld. UCSD.

4:20         Discussion.