Sessions

The latest research from across the interdisciplinary world of Biochemistry and Molecular Biology is in one place for you to explore. 

Daily, morning sessions feature invited presentations that will inform and inspire, and afternoon sessions showcase the most compelling research from submitted abstracts. 

Click the dates below for details of each day's sessions.

Sunday, April 7

10:00 a.m. – 12:00 p.m. W 303 ABC

Advances in Cryo-EM

  • Cryo-EM Analysis of Full-length Receptor Tyrosine Kinase
    Xiaochen Bai, University of Texas Southwestern Medical Center
  • Getting Better Images Easier for Single Particle Cryo-EM
    Anchi Cheng, New York Structural Biology Center
  • Cryo-EM Structure of the P Element Transposase Strand Transfer Complex
    Elizabeth H. Kellogg, Cornell University
  • Single Particle Cryo-EM Studies of Membrane Proteins
    Yifan Cheng, University of California, San Francisco Chair

10:00 a.m. – 12:00 p.m. W 304 AB

Autophagy and Proteostasis

  • Endoplasmic reticulum turnover via selective autophagy
    Ivan Dikic, Goethe University Frankfurt
  • Cellular recycling: Role of autophagy in aging and disease
    Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute
  • The Biochemical Program of Extreme Terminal Differentiation
    Daniel Finley, Harvard Medical School
  • New Links Between the Autophagy Machinery and Cellular Homeostasis
    Beth Levine, University of Texas Southwestern Medical Center Chair

10:00 a.m. – 12:00 p.m. W 304 CD

Catalysis and Enzyme Action

  • Covalent Intermediates in Flavoenzyme Catalysis
    Pablo Sobrado, Virginia Tech Chair
  • Homologous Trans-editing Factors with Broad Substrate Specificity Prevent Global Mistranslation
    Karin Musier-Forsyth, The Ohio State University
  • Discovering Novel Enzymes and Novel Metabolic Pathways
    John A. Gerlt, University of Illinois, Urbana-Champaign
  • Structural Insight into Pre-mRNA Splicing Catalyzed by the Spliceosome
    Rui Zhao, University of Colorado Denver Anschutz Medical Campus

10:00 a.m. – 12:00 p.m. W 304 EF

Epigenomics and Chromatin Dynamics

  • Regulation of chromatin states by nuclear pore proteins
    Maya Capelson, University of Pennsylvania, Perelman School of Medicine
  • Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
    Cigall Kadoch, Dana Farber Cancer Institute
  • Genome-wide Analysis of Enhancers in Development and Disease
    Bing Ren, University of California, San Diego/Ludwig Institute for Cancer Research
  • Chromatin Regulation of Tumor Responses to Immune Checkpoint Blockade
    Yang Shi, Boston Children's Hospital Chair

10:00 a.m. – 12:00 p.m. W 304 GH

Microbiome and Disease

  • Personalizing Food to the Gut Microbiome
    Lawrence David, Duke University
  • Bacterial Modification of Bile Acids Alters Host Physiology
    Sloan Devlin, Harvard Medical School
  • Connecting Variation in the Gut Microbiome with Development of Vascular Disease
    Federico E. Rey, University of Wisconsin-Madison
  • Human Skin Microbiome: Integrating Bacterial, Fungal and Viral Communities
    Julie Segre, National Human Genome Research Institute Chair

10:00 a.m. – 12:00 p.m. W 305 AB

Mitochondria Dysfunction and Disease

Organized by the Society for Experimental Biology and Medicine (SEBM)
Peter Stambrook Chair

  • New Insights into Mitochondrial Medicine
    Taosheng Huang, Cincinnati Children's Hospital Medical Center
  • Title tba.
    Douglas Wallace, Children's Hospital of Philadelphia
  • Mitochondria as Reversible Regulators of Skin Wrinkles and Hair Loss in Mice
    Keshav Singh, University of Alabama at Birmingham

10:00 a.m. – 12:00 p.m. W 307 AB

Synthetic Biology

  • Synthetic Biology Approaches to New Chemistry
    Michelle Chang , University of California, Berkeley Chair
  • Development of a Targeted Diversifier Allowing Mutation of All Nucleotide Types In Vivo
    John Dueber, University of California, Berkeley
  • Base Editing: Chemistry on a Target Nucleotide in the Genome of Living Cells
    David R. Liu, The Broad Institute
  • Biosynthesis of Complex Plant-Derived Natural Products
    Christina Smolke, Stanford University

10:00 a.m. – 12:00 p.m. W 306 AB

Using Large Sets of Data with Students

Sponsored by the ASBMB Education and Professional Development Committee
Victoria Moore and Martina Rosenberg Co-Chairs

  • Big Data Analysis and Visualization with Undergraduates: Training, Competency-Based Assessment and Meaningful Research Outcomes
    Ian Page, University of Maryland, College Park
  • Big Data in Biochem and Molecular Biology Education
    Justin Siegel, University of California, Davis
  • CRISPR as a CURE in an Undergraduate Course
    Heather Evans Anderson, Stetson University

3:00–5:00 p.m. W 305 AB

Novel Cancer Therapies: Free Radical Biology

Organized by the Society for Experimental Biology and Medicine (SEBM)

  • SOD Mimics and Cancer Therapy
    Douglas Spitz, University of Iowa Chair
  • Exploiting Redox Active Iron Metabolism For Cancer Therapy
    Bryan Allen, University of Iowa Hospitals and Clinics
  • Exploiting NAD metabolism for Cancer Therapy
    Xiumei Huang, Indiana University Simon Cancer Center
  • Pharmacological Ascorbate and Pancreas Cancer Therapy
    Joseph Cullen, University of Iowa

4:00–5:15 p.m. W 303 ABC

Advances in Neuronal Biochemistry

  • Regulation of SNARE-Dependent Membrane Fusion by Alpha-Synuclein
    Brenden Hawk, Iowa State University
  • Overexpression of Catalase in Mitochondria Mitigates the Inflammatory Effects of Simulated Microgravity and Social Isolation in Mouse Hippocampus
    Linda Guttmann, NASA
  • Neuronal membrane proteasomes target the nascentome to generate extracellular peptides that modulate neural network activity
    Seth Margolis, Johns Hopkins University School of Medicine
  • Analysis of neural networks of Caenorhabditis elegans by functional cellomics
    Yuji Yamauchi, Kyoto University
  • The E3 Ligase TRAF6 directs FOXP3 localization and facilitates Treg function through K63-type ubiquitination
    Joseph Barbi, Roswell Park Comprehensive Cancer Center

4:00–5:15 p.m. W 304 AB

Lipids and Inflammation

  • H-Ras Signaling Mediates Microglia Proliferation Contributing to Neuropathology in INCL Mice
    Tamal Sadhukhan, National Institute of Health Chair
  • Effects of Nicotine on Adipocyte Production of Resistin and NF-Kβ Translocation
    Jennica Peter, Fort Lewis College
  • TRPV4 regulates P. gingivalis lipopolysaccharide-induced exacerbation of oxidized LDL-mediated foam cell formation
    Shaik Rahaman, University of Maryland
  • Effect of interferon gamma on neutral lipid levels, lipid droplet formation, and antiviral responses in pancreatic islets and INS-1 β cells
    Nguyen Truong, Michigan State University
  • TNF ligand related molecule-1A inhibits atherosclerosis in apoE-deficient mice
    Dan Zhao, Nankai University

4:00–5:15 p.m. W 304 CD

Microbiome, Host-Parasite Interactions and Therapeutic Targets

  • Intestinal epithelial O-GlcNAc signaling is indispensable for anti-helminth type 2 immunity
    Ming Zhao, University of Minnesota Chair
  • Live-Cell Fluorescent Visualization of T3SS Needle and Its Dynamics
    Dorothy Cheng, Max Planck Institute of Terrestrial Microbiology
  • Enteropathogenic E. coli Hijacks Programmed Host-Cell Death Pathways by Interfering with the Higher Order Oligomerization of Immune System Proteins
    Ana Monserrat-Martinez, EMBL Australia Node in Single Molecule Science
  • Dissecting the mechanism of host shutoff by SARS coronavirus
    Anita Nag, Furman University
  • Oxidative stress-induced protein packaging in Enterotoxigenic Escherichia coli outer membrane vesicles and its functional impact on host-pathogen interactions
    Nichole Orench-Rivera, Duke University

4:00–5:15 p.m. W 304 EF

Non-coding RNAs

  • Long noncoding RNAs in immune response and inflammation
    Subhrangsu Mandal, University of Texas at Arlington Chair
  • microRNA 520b Mediates ATF5 Expression under Diverse Cellular Stress in Cancer Cells
    Kari Gaither, Washington State University
  • miRNAs regulate the expression of sterol-O acyltransferase 1 through inhibiting the 3′UTR of TGFβ receptor type 1 during embryonic development
    Han-Jen Lin, National Taiwan University
  • Alcohol induces TGFβ through suppression of miR-1946a
    Viranuj Sueblinvong, Emory University
  • lncRNA Chronos Exacerbates Pathological Cardiac Dysfunction and Fibrosis
    Ronald Neppl, Brigham and Women's Hospital

4:00–5:15 p.m. W 304 GH

Protein Structure and Function

  • Binding to the ribosome by eIF4B drives yeast translational control in response to membrane stressors
    Sarah Walker, University at Buffalo, SUNY Chair
  • Structural basis for teneurin function in circuit-wiring: A toxin motif at the synapse
    Demet Arac, University of Chicago
  • Filling in the gaps for the master regulator of biofilm formation in Bacillus subtilis: A structural and biochemical look at SinR and SinI
    Morgan Milton, Agile Sciences, Inc.
  • Structure of the WFIKKN2 Follistatin Domain and GDF8 Antagonism
    Jason McCoy, University of Cincinnati
  • Structural And Functional Versatility of Interferon-Inducible GTPases
    Qian Yin, Florida State University

4:00–5:15 p.m. W 307 AB

Signal Transduction and Regulation

  • Role of G protein-coupled receptor kinase 6 in Regulation of Platelet Activation through Selective GPCR Desensitization
    Soochong Kim, Chungbuk National University
  • GLP1 targets lncRNA Gas5 in diabetic adipocytes
    Ashley Lui, University of South Florida
  • Beta-arrestin 1: A novel partner in the regulation of the glucocorticoid receptor activity
    Maria Petrillo, National Institute of Environmental Health Sciences Chair
  • The Role of eIF2α in the Collagen Production in Hepatic Stellate Cell is Associated with Autophagic and Apoptotic Signaling
    Liu Qi-Lin, Department of Gastroenterology, The People’s Hospital of Guangxi Zhuang Autonomous Region
  • Ouabain Regulated Phosphoproteome Reveals Molecular Mechanisms Behind Na,K-ATPase Control of Cell Adhesion, Proliferation and Survival
    Elena Panizza, Cornell University

4:00–5:15 p.m. W 306 AB

Exploring Biochemistry Teaching and Learning

Victoria Moore Chair

  • Crowdsourcing the Development of Assessments for Biomolecular Visual Literacy
    Kristen Procko, University of Saint Joseph
  • Integrating civic scientific literacy skills in a Biochemistry course
    Ann Taylor, Wabash College
  • Are You a Scientist? Exploring Science Identity in a Structural Biology Outreach Program
    Brittney Wyatt, Rochester Institute of Technology
  • Developing an Inclusive Workshop Series for Faculty Mentoring Diverse Research Students
    Lea Michel, Rochester Institute of Technology
 

Monday, April 8

9:30–11:30 a.m. W 303 ABC

Glycobiology

  • Lectins from Bacteria and Fungi: Therapeutical Targets and Research Tools
    Anne Imberty, French National Center for Scientific Research Chair
  • A New Model for the Biochemistry of Pectin Synthesis: GUATs Synthesize Diverse HG Glycans in Structurally and Functionally Distinct Plant Cell Wall Polymers
    Debra Mohnen, University of Georgia Complex Carbohydrate Research Center
  • Roles of Galectins in Innate Immunity: First Barrier or Trojan Horse?
    Gerardo R. Vasta, University of Maryland School of Medicine
  • Glycobiology of Host-microbe Interactions in the Gut
    Nathalie Juge, Quadram Institute

9:30–11:30 a.m. W 304 AB

Inequities in Precision Medicine

Sponsored by the ASBMB Minority Affairs Committee
Sonia Flores, University of Colorado School of Medicine Chair

  • Populations from under-represented backgrounds are not adequately represented in clinical databases
    Kathleen Barnes, University of Colorado School of Medicine
  • Pharmacogenomics in Indigenous Populations
    Katrina G. Claw, University of Washington
  • Leveraging Diversity for Population Genomic Health
    Eimear Kenny, Icahn School of Medicine at Mount Sinai
  • Role of Ancestry Genes in Asthma Susceptibility.
    Victor Ortega, Wake Forest School of Medicine

9:30–11:30 a.m. W 304 CD

Inflammation and Disease

  • To Code Or Not To Code: What Is The Linc?
    Richard Flavell, Yale University
  • Regulators of Inflammatory Responses
    Thirumala- Devi Kanneganti, St. Jude Children's Research Hospital
  • Role of Inflammation in Control of Hepatic Lipid Metabolism-New Insights to the Pathogenesis of NASH
    Michael Karin, University of California, San Diego
  • Sounding the Alarm and Putting Out the Fire: New Mechanistic Insights into Inflammatory Cell Death
    Judy Lieberman, Harvard University Medical School/Boston Children's Hospital Chair

9:30–11:30 a.m. W 304 EF

Mitochondrial Biology

  • Mitochondrial Driving Forces and Metabolic Resilience.
    Deborah Muoio, Duke University Molecular Physiology Institute
  • Altering Mitochondrial Bioenergetic Efficiency
    Darrell Neufer, East Carolina Diabetes & Obesity Institute, East Carolina University Chair
  • Regulation of Mitochondrial Metabolism by Reversible Phosphorylation
    David Pagliarini, Morgridge Institute for Research, University of Wisconsin-Madison
  • Metabolic Coordination of Tumor Suppression
    Lydia Finley, Memorial Sloan Kettering Cancer Center

9:30–11:30 a.m. W 304 GH

RNA Structural Dynamics

  • Using Conformational Penalties to Assess the Structure Dependence of RNA Cellular Function
    Hashim Al-Hashimi, Duke University School of Medicine Chair
  • Modification of mRNA by 2'-O-methylation
    Christopher Lee Holley, Duke University School of Medicine
  • Quality Control During 40S Ribosome Assembly
    Katrin Karbstein, The Scripps Research Institute
  • Dynamic Control of Gene Expression during mRNA Export and Translation
    Susan Wente, Vanderbilt University

9:30–11:30 a.m. W 307 AB

Single Molecule Single Cell

  • Fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase: single-molecule picometer-resolution nanopore tweezers (SPRNT)
    Richard H. Ebright, Waksman Institute of Microbiology, Rutgers University
  • Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH
    Long Cai, California Institute of Technology
  • Three-dimensional in Situ Sequencing of Single Cells in Intact Tissue
    Xiao Wang, Stanford University
  • Single Cell Genomics: When Stochasticity Meets Precision
    Sunney Xie, Peking University Chair

9:30–11:30 a.m. W 305 AB

Cryo-EM and Re-revolution of Structural Biology

Organized by the Society for Experimental Biology and Medicine (SEBM)
Thomas Thompson, Chair

  • Single Particle cryo-EM of Membrane Proteins
    Yifan Cheng, HHMI/University of California, San Francisco
  • Imaging Smaller and Smaller Macromolecules at Higher and Higher Resolution Using Conventional Single-particle Cryo-EM
    Mark Herzik, University of California, San Diego
  • Single-particle cryo-EM analysis of lipopolysaccharide transport driven by ABC transporters
    Maofu Liao, Harvard Medical School

9:30–11:30 a.m. W 306 AB

Transitions at the Mid-Career Point

Sponsored by the ASBMB Education and Professional Development Committee

  • Using Scientific Teaching to Grow Your Academic Profile as an Educator and Scientist
    Richard A. Cardullo, University of California, Riverside
  • Transitioning from Academia to Industry and Back Again
    Ivor T. Knight, Penn State, Behrend
  • The Post-tenure Sabbatical
    Victoria Moore, Elon University Co-Chair
  • From Research to Faculty Developer
    Martina Rosenberg, University of Connecticut Co-Chair
  • Transitioning to Leadership in Higher Education
    Reema Zeineldin, Mercy College

1:00–3:00 p.m. W 305 AB

Stem Cells and Therapy

Organized by the Society for Experimental Biology and Medicine (SEBM)
James Kang and Peter Stambrook, Co-Chairs

  • Title tba.
    James Kang, University of Tennessee Health Science Center
  • Organoids in the Gut
    James Wells, Cincinnati Children's Hospital Medical Center
  • Stem Cell Therapy for Ischemic Stroke
    Cesario Borlongan, University of South Florida

2:30–3:45 p.m. W 303 ABC

Molecular and Cellular Proteomics, an ASBMB Journal Symposium

Al Burlingame, University of California, San Francisco, Editor, MCP Chair

  • The Role of Mass Spectrometry in the Advancement of HLA Epitope Prediction
    Jennifer Abelin, Neon Therapeutics
  • Developing Structural Interactomics and its Application in Cell Biology
    Fan Liu, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
  • Proteomic Approaches to Better Understand Transcriptional Regulation
    Sam Myers, Broad Institute
  • Proteoform Dynamics in Steady-State
    Jana Zecha, Technical University of Munich

2:30–3:45 p.m. W 304 AB

Chemical Modifications and Mechanisms of DNA Metabolism

  • Protein Lysine Acetylation Regulates the Choice of the Okazaki Fragment Maturation Pathway
    Lata Balakrishnan, Indiana University–Purdue University Indianapolis Chair
  • BRCT domains contain an intrinsic post-translational modification (PTM) recognition code that affects it stability
    Jamaine Davis, Meharry Medical College
  • Mechanistic insight into oxidized ribonucleotide (8-oxo-GTP) insertion by a DNA polymerase
    Mallory Smith, University of Kansas Medical Center
  • Elongin and the Elongin A ubiquitin ligase complex in transcription and the response to DNA damage
    Juston Weems, Stowers Institute for Medical Research
  • Mechanisms of DNA ligation
    Patrick O'Brien, University of Michigan

2:30–3:45 p.m. W 304 GH

Enzyme Chemistry and Catalysis

  • Function, timing and catalytic mechanism of NosN, a class C radical SAM methylase involved in the biosynthesis of nosiheptide's side-ring system
    Bo Wang, Pennsylvania State University
  • Marine worm bioluminescence is slowly revealing its secrets
    Evelien De Meulenaere, University of California, San Diego Scripps Institution of Oceanography
  • Conditional Protein Splicing of Inteins from Extremophiles
    Kenneth Mills, College of the Holy Cross
  • Bidirectional Degradation of DNA Cleavage Products Catalyzed by CRISPR/Cas9
    Zucai Suo, Florida State University Chair
  • The Nudix Superfamily: a structural perspective
    Sandra Gabelli, Johns Hopkins University

2:30–3:45 p.m. W 306 AB

Exploring Experimentation in Biochemistry Lab and Non-Lab Settings

Martina Rosenberg, Chair

  • Engaging Nontraditional Students by CURE-ing Microbes on Ocean Plastics
    Ana Maria Barral, National University
  • Creating and Using the Malate Dehydrogenase CURE Community to Explore Critical Aspects of Sustainable Protein Centric CUREs
    Jessica Bell, University of San Diego
  • Power of PCR pre-labs and a co-mentoring community group: Increasing impacts on skills and confidence
    Beverly Smith-Keiling, University of Minnesota
  • Supporting Learning in the Undergraduate Biochemistry Laboratory at an Australian University Through a 3-Phase Approach Using Technology, eNotebooks and Partnering with Students
    Tracey Kuit, University of Wollongong
  • Managing Course Embedded Research Projects of Any Size Using the Open Science Framework
    Christopher Berndsen, James Madison University

2:30–3:45 p.m. W 304 CD

Glycosyltransferases and Hydrolases

  • Assessing Fucosyltransferase Activity via MSn
    David Ashline, University of New Hampshire Chair
  • Targeting the O-GlcNAc Transferase to Specific Proteins Using RNA Aptamers
    Yi Zhu, Johns Hopkins University
  • The Mammalian UDP-Galactose 4′-Epimerase (GalE) Is Required for Cell Surface Glycome Structure and Function
    Alyssa Florwick, Duke University School of Medicine
  • Fine Tuning of Hemoglobin Switching and Erythropoiesis
    Matthew Parker, University of Kansas Medical Center
  • Identification of Nutrient Metabolites Capable of Altering the Epigenetic Status at Specific Loci
    Koji Hayakawa, University of Tokyo

2:30–3:45 p.m. W 304 EF

Regulation of Lipid Metabolism

  • O-GlcNAc signaling orchestrates metabolic adaptation to prolonged fasting
    Mindian Li, Yale University School of Medicine Chair
  • Acyl-CoA Synthetase 6 Mediates Brain Docosahexaenoic Acid (DHA) Enrichment and Neuroprotection
    Regina Fernandez, East Carolina University
  • Diacylglycerol links lipid droplets and tubular ER during growth resumption from stationary phase
    Suriakarthiga Ganesan, University of Calgary
  • Fatty Acids Bind to Them1, a Negative Regulator of Thermogenesis in Brown Adipose Tissue
    Matthew Tillman, Emory University
  • RNA seq Analysis of Livers from Mice Lacking Fatty Acid Transport Protein 2 (FATP2) Demonstrate Metabolic Linkages in Genes Involved in PPARa-responsive Lipid Metabolic Pathways
    Vincent Perez, University of Nebraska-Lincoln

2:30–4:30 p.m. W 307 AB

ASBMB Alice and CC Wang Award in Molecular Parasitology Lecture and Symposium

  • “Prison Break” Toxoplasma egress from infected cells is a tightly programmed event
    Dominique Soldati-Favre, University of Geneva
  • Molecular Genetics for Cryptosporidium
    Boris Striepen, University of Pennsylvania School of Veterinary Medicine
  • Environmental signals control transmission stage formation in Plasmodium falciparum
    Nicolas Brancucci, Swiss Tropical and Public Health Institute
  • Metabolic interplay and flexibility in the intracellular Trypanosoma cruzi-host cell interaction
    Barbara Burleigh, Harvard University T.H. Chan School of Public Health

3:00–5:00 p.m. W 305 AB

Molecular Medicine: A Student Organized Symposium

Organized by the Society for Experimental Biology and Medicine (SEBM)
W. Zimmer, R. Fenske, N. Fuentes and W. Zhou, Co-Chairs

  • Understanding How Mitotic Regulators Drive the Epithelial to Mesenchymal Transition in Breast Cancers
    Harold Saavedra, Ponce Health University
  • Isobutyldeoxynyboquinone (IBDNQ) Induces Catastrophic Metabolic Failure in NQO1 Positive Cancer Cells
    Matthew Merritt, University of Florida College of Medicine
  • Sex Difference in Liver Cancer Incidence: A Bilious Insight
    Sayeepriyadarshini Anakk, University of Illinois

4:00–5:15 p.m. W 304 AB

Epigenetic Factors that Contribute to Gene Regulation

  • Investigating the Mechanisms by which the Methyl-CpG Binding Protein ZBTB38 Identifies Interacting Partners and Mediates Transcription
    Bethany Buck-Koehntop, University of Utah Chair
  • Epigenetic Memory, Melanoma Antigen Genes (MAGEs) and Cancer
    Saumya Ramanathan, Fisk University
  • Regulation of mitochondrial DNA transcription by protein post-translational modifications
    Kristin Dittenhafer-Reed, Hope College
  • SV40 virion formation functions as a novel epigenetic switch controlling early and late transcription
    Barry Milavetz, University of North Dakota
  • Enhancer regulation by H3K4 methyltransferases MLL3/MLL4
    Kai Ge, National Institute of Diabetes and Digestive and Kidney Diseases

4:00–5:15 p.m. W 303 ABC

Genomics, Proteomics and Metabolomics

  • Activity-based profiling of Phosphoprotein Phosphatases from Yeast to Humans
    Arminja Kettenbach, Geisel School of Medicine at Dartmouth Chair
  • Proteomic Dissection of the Spindle Assembly Checkpoint
    Yenni Garcia, University of California, Los Angeles
  • BioCyc: A Genomic and Metabolic Web Portal with Multiple Omics Analytical Tools
    Ron Caspi, SRI International
  • Thinking Outside the Informatics Box: Computed Chemical Properties for Protein Function Annotation
    Mary Jo Ondrechen, Northeastern University
  • Gut Check on Air Pollution: Effects of Biodiesel Ultrafine Particles on Gut Microbial Metabolism
    Jiangjiang Zhu, The Ohio State University

4:00–5:15 p.m. W 304 EF

Journal of Lipid Research, an ASBMB Journal Symposium

George Carman, Rutgers University, Editor, JLR Chair

  • Complex genetic determinants of plasma lipoproteins
    Jacqueline S. Dron, Western University
  • The structure of apoA-II on HDL reveals novel insights into its regulation of lipoprotein composition and function
    John Melchior, University of Cincinnati
  • Small HDL, diabetes, and proinflammatory effects in macrophages
    Vishal Kothari, University of Washington
  • Retinol Binding Protein 4 (RBP4) in Adipocytes and Obesity
    Igor Shmarakov, Columbia University
  • Chlorolipids: Mediators and Outcome Predictors of Sepsis
    Daniel Pike, Saint Louis University Health Science Center

4:00–5:15 p.m. W 304 CD

Protein-Glycan Interactions

  • Probing galectin-3 extracellular activity using synthetic oligomers with defined carbohydrate-recognition domain valency
    Shaheen Farhadi, University of Florida
  • Novel Rigid Glycomimetics to Inhibit Influenza Infection
    Robert Woods, University of Georgia Chair
  • Glycosaminoglycan Recognition of Neutrophil-Activating Chemokines
    Balaji Nagarajan, Virginia Commonwealth University Institute for Structural Biology, Drug Discovery and Development
  • Investigation of an antifungal peptide, Diapausin, from Manduca sexta
    Miao Li, Kansas State University
  • The New Buzz About Sugars: Novel N-Glycans in Bees, Moths and Mosquitoes
    Iain Wilson, University of Natural Resources and Life Sciences, Austria

4:00–5:15 p.m. W 304 GH

Sensing

  • Electrochemical Biosensor Targeting the Cancer Biomarker Human Ecto-NOX Disulfide-Thiol Exchanger 2 (ENOX2)
    Andrew Bonham, Metropolitan State University of Denver
  • Monothiol Glutaredoxins Grx3/4 and the BolA Protein Bol2 Modulate Iron Sensing and Regulation in Yeast S. cerevisiae
    Angela-Nadia Albetel, University of South Carolina
  • Core-Shell Nanoparticle Probe Scintillation Proximity Assays for Biological Samples
    Colleen Janczak, University of Arizona
  • Activity-dependent ATP Release from Neurons and Astrocytes
    Mathew Tantama, Purdue University Chair
  • Fluorescence Spectroscopic Analysis of TonB-dependent Transport in Klebsiella pneumoniae
    Ashish Kumar, Kansas State University
 

Tuesday, April 9

9:30–11:30 a.m. W 303 ABC

Aging and Longevity

  • Mitochondria, Metabolism and Aging
    Toren Finkel, University of Pittsburgh Aging Institute
  • Endogenous DNA Damage as a Driver of Senescence and Aging
    Laura Niedernhofer, University of Minnesota Chair
  • The Role of Mitochondrial Peroxide Release in the Mechanisms Underlying Age-Related Sarcopenia
    Holly Van Remmen, Oklahoma Medical Research Foundation
  • Lysosomal Metabolic Cues in Orchestrating Cellular and Organism Homeostasis
    Meng Wang, Baylor College of Medicine

9:30–11:30 a.m. W 304 AB

Breakthroughs in Plant Biochemistry

  • The 4th Dimension of Transcriptional Networks: TIME
    Gloria M. Coruzzi, New York University Center for Genomics and Systems Biology
  • The Plant Social Network: Volatiles and Their Release
    Natalia Dudareva, Purdue University Chair
  • Evolution and the Single Cell: Metabolic Diversity in Tomato
    Robert Last, Michigan State University
  • Synthetic Evolution of C4 Photosynthesis
    Andreas Weber, Heinrich Heine University

9:30–11:30 a.m. W 304 CD

Circadian Rhythm

  • Advantages and Disadvantages of Circadian Rhythms: A Tale of Two Microbes
    Michael Rust, University of Chicago, Institute for Genomics and Systems Biology
  • Circadian Control of Animal Physiology
    Amita Sehgal, University of Pennsylvania Chair
  • Circadian Biology in Translation
    John Hogenesch, Cincinnati Children's Hospital Medical Center
  • Molecular Genetics of Human Sleep Behaviors
    Ying-Hui Fu, University of California, San Francisco

9:30–11:30 a.m. W 304 EF

DNA Repair, Recombination and Replication

  • Responses to Replication Stress in Human Cells
    Anja-Katrin Bielinsky, University of Minnesota Chair
  • Genomic and Proteomic Signatures of Replication Fork Collapse
    Eric Brown, Abramson Family Cancer Research Institute
  • Replication Origin Licensing Deficiency and Genome Instability During Cell Cycle Re-entry from Quiescence
    Jean Cook, University of North Carolina, Chapel Hill
  • How Replication Stress Drives Genome Instability
    Susan Forsburg, University of Southern California

9:30–11:30 a.m. W 304 GH

Lipid Metabolism

  • Glycerolipid Intermediates as Signaling Mediators in Physiology and Disease
    Brian Finck, Washington University in St. Louis School of Medicine Chair
  • The Regulation and Consequences of Lipid Droplet Catabolism
    Doug Mashek, University of Minnesota
  • Regulation of Adipose Lipid Metabolism
    Hei Sook Sul, University of California, Berkeley
  • Acetyl-CoA Metabolism and the Response to Dietary Sugar
    Kathryn Wellen, University of Pennsylvania Perelman School of Medicine

9:30–11:30 a.m. W 305 AB

Sirtuins in Cancer Biology

Organized by the Society for Experimental Biology and Medicine (SEBM)

  • The SIRT3-MnSOD-Ac Axis in Tumorigenesis and Tumor Cell Resistance
    David Guis, Northwestern University Chair
  • SIRT3 Plays a Key Role in Adaptive Mitochondrial Metabolism
    Jian-Jian Li, University of California, Davis
  • NR Promotes Fatty Acid Oxidation to Fuel the Regenerating Liver
    J. Baur, University of Pennsylvania Perelman School of Medicine

2:30–3:45 p.m. W 303 ABC

ASBMB Herbert Tabor Young Investigator Award Symposium

George DeMartino, University of Texas Southwestern Medical Center, Associate Editor, Journal of Biological Chemistry Chair

  • Dynamic disulfide exchange in a crystallin protein in the human eye lens promotes cataract-associated aggregation
    Evgeny Serebryany, Harvard Universtiy
  • Antibody Recognition of a Polysaccharide Common To Many Microbes and Biofilms
    Caroline Soliman, RMIT University
  • Metabolic Origin of the Fused Aminoacyl tRNA Synthetase, Glutamyl-prolyl tRNA Synthetase
    Sandeep M. Eswrappa, Indian Institute of Science
  • Mallostery: Ligand-dependent Misfolding as a Strategy for Protein Regulation
    Margaret Wangeline, University of California, San Diego
  • Can Cellular Labile Iron Pool be Considered Solely a Pro-oxidant Species in Cells?
    Fernando Cruvinel Damasceno, FFCLRP - Universidade de Sao Paulo

2:30–3:45 p.m. W 304 GH

Cancer Signaling and Therapeutics

  • Strength in Complementary Weaknesses: An Effective Dual Specificity Antibody Approach against Ovarian Cancer
    Jogender Tushir-Singh, University of Virginia Cancer Center Chair
  • Gemcitabine Sensitivity is Improved in Pancreatic Cancer by CYR61/CCN1-Depletion-Mediated Upregulation of dCK and Suppression of CTGF
    Arnab Ghosh, Kansas City VA Medical Center
  • Pimavanserin tartrate: A potential drug for pancreatic cancer therapy in future
    Sharavan Ramachandran, Texas Tech University Health Sciences Center
  • Antimetastatic potential of Atovaquone against triple negative breast cancer: Involvement of the integrin-FAK-Src pathway
    Nehal Gupta, Texas Tech University Health Sciences Center
  • ABC Transporter-Mediated Multidrug Resistance in Prostate Cancer Cells
    Toluleke Famuyiwa, Florida Atlantic University

2:30–3:45 p.m. W 307 AB

Enzymes and Enzyme Cofactors

  • Structural Dynamics Couple Substrate Recognition with Allosteric Domain Communication in Nonribosomal Peptide Synthetases
    Dominique Frueh, Johns Hopkins School of Medicine
  • Understanding oxygen tolerant [Fe-Fe] hydrogenase
    Alexey Silakov, Pennsylvania State University
  • Nitrite and NO Processing by CblC: A Human B12 Trafficking Chaperone
    Romila Mascarenhas, University of Michigan Medical School
  • Kinetic Advantages of the Run-On Oligomer or Filamentation Mechanism of a DNA Cleaving Enzyme
    N. C. Horton, University of Arizona Chair
  • The lower base of corrinoid small molecules regulates reductive dehalogenase enzyme function in Dehalococcoides species
    Nannan Jiang, University of Tennessee

2:30–3:45 p.m. W 304 EF

Metabolism and Bioenergetics

  • Isoleucine Serves as a Precursor for the Synthesis of β-Alanine in Plants
    Kerry Rouhier, Kenyon College
  • Serum Lipoproteins Regulate Hypoxia-Inducible Factors Under Normoxia
    Peter Espenshade, Johns Hopkins University School of Medicine Chair
  • Functional decline in brown adipose progenitors during BAT remodeling
    Hai-Bin Ruan, University of Minnesota
  • Autophagy modulates lipid metabolism in Liver Kinase B1 (LKB1)-deficient Kras-driven lung tumorigenesis
    Vrushank Bhatt, Rutgers University
  • Quantitative Survey of NAD+ Flux in Aged Mice
    Melanie McReynolds, Princeton University

2:30–3:45 p.m. W 304 CD

Post-translational Modifications

  • A Tail of Kinase Regulation: How C-termini Modulate CK1 Substrate Phosphorylation
    Sierra Cullati, Vanderbilt University
  • Modulation of CHIP-mediated degradation through posttranslational modifications
    Richard Page, Miami University
  • ERK Controls Myosin Phosphatase and Cell Migration through RSK Phosphorylation of MYPT1
    Michelle Mendoza, University of Utah Chair
  • Proteomic and Phosphoproteomic Signatures of Severe Alcoholic Hepatitis
    Josiah Hardesty, University of Louisville
  • Mitochondrial Oxidative Stress and Adipocyte Protein Carbonylation
    Yimao Huang, University of Minnesota

2:30–3:45 p.m. W 306 AB

Protein Interactions, Modifications and Regulation

  • Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating
    Robert Tomko Jr., Florida State University College of Medicine Chair
  • A Ubiquitin-dependent Switch during Assembly of the Proteasomal ATPases Mediated by Not4 Ubiquitin Ligase
    Soyeon Park, University of Colorado Boulder
  • Evolution of differential 4-1BB signaling in Human and Murine immune system
    Aruna Bitra, La Jolla Institute for Immunology
  • Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
    Jie Yang, Case Western Reserve University
  • Palmitoylation-Dependent Regulation of RhoGTPase Signaling and Cardiac Pathophysiology
    Matthew Brody, Cincinnati Children's Hospital

2:30–3:45 p.m. W 304 AB

RNA Regulatory Mechanisms and Disease

Patrick Grant, University of Virginia School of Medicine Chair

  • Human Tat-specific Factor 1 Binds and Exports HIV-1 RNA to the Cytoplasm
    Heather Miller, High Point University
  • A regulatory interplay: hnRNP A1 and AUF1 compete for the same IRES domain to regulate viral translation in EV71
    Jesse Davila-Calderon, Case Western Reserve University
  • Molecular and Functional Dissection of Distinct mRNA Export Pathways
    Samson Obado, The Rockefeller University
  • The role of lncRNA HOTAIR in the regulation of glucose metabolism
    Monira Obaid, University of Texas at Arlington
  • Uncovering Caprin1’s biological role to understand it’s function in autism
    Criseyda Martinez, New York University School of Medicine

3:00–5:00 p.m. W 305 AB

Biotherapies and Immunotherapies

Organized by the Society for Experimental Biology and Medicine (SEBM)
Farzin Farzaneh and P. Stambrook, Co-Chairs

  • Cells, Genes and Proteins for Active Immune Therapy of Cancer
    Farzin Farzaneh, King's College London
  • Ion Channels in Cancer Immunosurveillance
    Laura Conforti, University of Cinncinatti
  • Vaccination Against Neoantigens Induced in Concurrent and Future Tumors
    Eli Gilboa, University of Miami

4:00–5:15 p.m. W 307 AB

Advances in Drug Delivery

Squire Booker, Pennsylvania State University Chair

  • Massively Parallel Protein Design to Develop Enzymes for Next-Generation Chemotherapy
    Brahm Yachnin, Rutgers University
  • Lipophilic Modification of an Anti-Cancer Stem Cell Agent Improves Pharmacokinetic and Anti-Cancer Properties
    Shravan Morla, Virginia Commonwealth Univeristy
  • Nature-Made Catalytic Antibody Platform: From Heisenberg’s Uncertainty Principle to the Brink of Medical Interventions
    Stephanie Planque, Covalent Bioscience Inc.
  • Optogenetic activation and inactivation of the neurotrophin pathway in live cells
    Payel Mondal, University of Illinois Urbana Champaign
  • Discovery of a Plant-derived Cell-penetrating Proteasome Inhibitor
    Antony Kam, Nanyang Technological University

4:00–5:15 p.m. W 304 GH

Biochemistry and Biology of Cancer

  • Overexpression of PCDH7 and SET Leads to Aberrant ERK and AKT Signaling and Promotes Prostate Cancer Progression
    Gauri Shishodia, Louisiana State University Health Sciences Center Chair
  • 2D vs. 3D – Triple negative breast cancer spheroid formation induces quantitative heterogeneity of VEGF and PDGF receptor profiles and modulates cytosolic phosphorylation
    Ashley Oyirifi, University of Illinois
  • Expression of chondroitin sulfotransferases (CHST3,7,11,15) and chondroitin sulfatases in normal and malignant prostate stroma and epithelium
    Joanne Tobacman, University of Illinois at Chicago
  • Protease-activated receptor 2 (PAR-2) biased agonism in ovarian cancer progression
    Nisha Pawar, University of Maryland Baltimore School of Medicine
  • Spatiotemporal Control of Glycolysis Modulates ATP Generation and Enhances Restoration of Endothelial Barrier Function Following Inflammatory Injury
    Priyanka Gajwani, University of Illinois

4:00–5:15 p.m. W 306 AB

Biochemistry of Organelles and Organelle Trafficking

David Bernlohr, University of Minnesota Chair

  • Exploring the functional role of an ancient mitochondrial fatty acid synthesis pathway
    Katja Dove, University of Utah
  • Acid Sphingomyelinase Deficiency Protects Mitochondria and Improves Function Recovery after Traumatic Brain Injury
    Sergei Novgorodov, Medical University of South Carolina
  • 4D cell biology: Big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell-derived intestinal organoids
    Johannes Schöneberg, University of California, Berkeley
  • PCID2 influences BRCA1/BARD1 Localization and Centrosome Duplication through its functions in Nuclear Protein and mRNA Export
    Karen Resendes, Westminster College
  • Cargo delivery to lysosome-related organelles universally relies on the recognition of sorting signal by adaptor proteins
    Seunghyi Kook, Vanderbilt University School of Medicine

4:00–5:15 p.m. W 304 CD

Glycan Biotechnology and Drug Development

  • Synthesis and Development of peptidoglycan fragment microarray and probes to investigate innate immune signaling
    Junhui Zhou, University of Delaware
  • Monofunctionalization with dextrans endows cell-penetrative properties to proteins
    Henry Kilgore, Massachusetts Institute of Technology
  • Protein Engineering and Glycan Optimization Improves Pharmicokinetics of an Enzyme Biologic 10-fold
    Demetrios Braddock, Yale University Chair
  • Identification of a Naturally-occurring Heparin-binding Peptide Preferentially Targeting the Nucleolus
    Shining Loo, Nanyang Technological University
  • Glycosaminoglycans and Glycosaminoglycan Mimetics as Human Neutrophil Elastase Inhibitors for Cystic Fibrosis Management
    Daniel Afosah, Virginia Commonwealth University

4:00–5:15 p.m. W 304 EF

Obesity

  • Molecular mechanism of cereblon-dependent down regulation of AMP-activated protein kinase
    Seung-Joo Yang, Gwangju Institute of Science and Technology
  • The role of lncRNA CRNDE in obesity-associated endothelial dysfunction
    Nghi Nguyen, University of Nebraska-Lincoln
  • Influence of Gut Microbiome on Induction of Obesity Ihab
    Sheikh Hanafi, Spartan Health Sciences University
  • The influence of neonatal intake of curcumin on expression of genes associated with lipid metabolism and inflammatory cytokines: Implication on obesity
    Emmanuel Mukwevho, North-West University
  • Hepatic Oleate Deficiency Represses De Novo Lipogenesis and Enhances Systemic Glucose Utilization Through FGF21 During High Carbohydrate Feeding
    James Ntambi, University of Wisconsin-Madison

4:00–5:15 p.m. W 304 AB

RNA Editing and Alternative Splicing

  • Genetic Delivery of RNA Therapeutics to Alter the Expression of Oncogenic Transcripts in Glioblastoma
    Martin Hicks, Monmouth University Chair
  • The Role of Adenosine Deaminase Acting on RNA (ADAR) Family of Proteins in Hyperoxia Induced Acute Lung Injury
    Ramani Soundararajan, University of South Florida
  • The Roles of the Essential Proteins Dib1, Prp31, Prp6 and the U5 snRNA During Splicing
    Addie Embry, Trinity University
  • Energetics and Interfacial Interactions of Spliceosomal Protein Dib1 Predicted with MD Simulations
    Rachel Goldstein, Trinity University
  • The Synaptosome Associated Protein-23 is Necessary for Skeletal Muscle Myogenesis
    Jennifer Gamarra, University of North Carolina at Chapel Hill

4:00–5:15 p.m. W 303 ABC

Signal Transduction and Cellular Regulation

  • The PH Domain of ASAP1 Binds N terminus of Arf1 in Presence of PIP2 for Efficient GTPase-activating Protein Activity
    Neeladri Roy, National Cancer Institute Chair
  • Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress
    Guillaume Thibault, Nanyang Technological University
  • Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling
    Tianmin Fu, Boston Children's Hospital
  • Inducibility and role of mTORC1 signaling in intestinal epithelial cells as a result of cell differentiation
    Harleen Kaur, University of Nebraska-Lincoln
  • A Cushing Syndrome Mutation of Protein Kinase A C-subunit Disrupts the Internal Allosteric Network Affecting Regulation and Substrate Specificity
    Caitlin Walker, University of Minnesota, Twin Cities