The latest research from across the interdisciplinary world of Biochemistry and Molecular Biology is in one place for you to explore. Daily, morning sessions feature invited presentations that will inform and inspire! Click the dates below for speaker details.

*denotes Symposia chair

Sunday, April 22

Biochemical Communication Between the Microbiome and the Host  

  • Andres Gomez, J. Craig Venter Inst. 
    Host microbe interactions in the primate gut: Implications for human origins
  • Lora Hooper*, UT Southwestern Med. Ctr.
    Metabolism, the microbiome, and the circadian clock
  • Eric Martens, Univ. of Michigan Med. Sch. 
    Bacterial metabolism in the colonic mucus layer: An axis between health and disease
  • Gil Sharon, Caltech 
    Human microbiomes from autism spectrum disorder induce behavioral symptoms in mice

Can We Target Aging? presented by the Society for Experimental Biology and Medicine  

  • Nir Barzilai*, Albert Einstein Coll. of Med.  
  • Judith Campisi, Lawrence Berkeley National Laboratory  
  • Ana Maria Cuervo, Albert Einstein Coll. of Med.  
  • Thomas Rando, Stanford Univ.  

Intrinsically Disordered Proteins and their Regulation and Functions   

  • M. Madan Babu, Univ. of Cambridge 
    The role of disordered regions in GPCR-G protein signalling 
  • H. Jane Dyson*, Scripps Res. Inst. 
    How do intrinsically disordered viral proteins hijack the cell?
  • Rohit Pappu, Washington Univ. in St. Louis
    Disordered regions as modulators of function and phase behavior of multivalent proteins
  • Elizabeth Rhoades, Univ. of Pennsylvania 
    Investigating functions of dysfunctional proteins

Lipid Signaling and Metabolism  

  • John Burke, University of Victoria 
    Walter A. Shaw Young Investigator Award in Lipid Research
    Probing the structure, dynamics, and regulation of lipid signalling enzymes and their role in human disease 
  • Vytas Bankaitis, Texas A&M Health Science Ctr. 
    A Golgi lipid signaling pathway that controls neural stem cell polarity in the developing neocortex 
  • Rosalind Coleman, Univ. of North Carolina 
    Fatty acid compartmentalization
  • Jean Gruenberg, Univ. of Geneva 
    Endosomal lipids in trafficking and signaling
  • Michael Wakelam*, Babraham Inst.  
    Using lipidomics pathway analysis to identify potential therapeutic targets

Novel Enzymology  

  • Ron Raines*, Univ. of Wisconsin-Madison 
    Ribonuclease: From kcat/KM to the Clinic
  • Dan Tawfik, Weizmann Inst.  
    How do enzymes evolve?
  • Paul Thompson, Univ. of Mass. Med. Sch.  
    Picking the PADlock:  Chemical strategies to interrogate the Protein Arginine Deiminases
  • Suzanne Walker, Harvard Med. Sch. 
    O-GlcNAC transferase: Diverse outcomes from the same active site

RNA Form and Function  

  • Juan Alfonzo, Ohio State Univ. 
    Bridging the gap between RNA editing and modification: A 10-year solution to a 25-year problem
  • Lydia Contreras*, UT, Austin 
    Functional characterization and design of regulator RNAs using novel high-throughput tools
  • Andrew Ellington, UT Austin              
    How to Balance the Many Roles of tRNAs During the Creation of New Genetic Codes
  • Ya-Ming Hou, Thomas Jefferson Univ.   
    NA methylation: A mechanism to regulate gene expression

Strategically Building Your CV at Every Career Stage  

  • Nicquet Blake, UT Health San Antonio
    Career visualization and execution             
  • Mary CanadyComprendia, LLC and San Diego Biotechnology Network
    Finding your inner extrovert for career growth  
  • Robert To, Bayer HealthCare
    An unplanned career: from research to regulation  

Discussion Panel: Strategically Building Your CV at Every Career Stage  

  • Nicquet Blake*UT Health San Antonio  
  • Rachell Booth, Univ. of the Incarnate Word  
  • Mary Canady, Comprendia, LLC and San Diego Biotechnology Network  
  • Marvin PayneLa Sierra Univ., (Moderator)  
  • Robert To, Bayer HealthCare  

Synthetic Biology presented by the Society for Experimental Biology and Medicine  

  • Julius Lukus, Northwestern Univ.
    Teaching ancient molecules new tricks: Unlocking the potential of RNA synthetic biology
  • Lulu Qian, Cal Tech
    A cargo-sorting DNA robot
  • Peter G. Schultz, Scripps Research Inst.
    Playing with the molecules of life
  • Peter Stambrook*, Univ. of Cincinatti    
  • Yuval Elani, Imperial Col., London
    Engineering membrane-bound microsystems as artificial cells

Workshop: Strategically Building Your CV at Every Career Stage  

  • Nicquet Blake, UT Health San Antonio  
  • Rachell Booth, Univ. of the Incarnate Word  
  • Mary Canady, Comprendia, LLC and San Diego Biotechnology Network  
  • Marvin Payne, La Sierra Univ., (Moderator)    
  • Robert Toi, Bayer HealthCare  

Student Led Symposia presented by the Society for Experimental Biology and Medicine  

  • David Boothman, Univerity of Texas Southwestern 
  • Inder Verma, Salk Institute 
  • Katija Lamia, Scripps  
  • Paul Mischel, UC San Diego  

Monday, April 23

Adapting Proteostasis to Ameliorate Neurodegenerative Diseases  

  • Jason Gestwicki, Univ. of California, San Francisco 
    Targeting protein-protein interactions in chaperone complexes to normalize proteostasis
  • Jeffrey Kelly*, Scripps Inst.  
    Adapting the Chemistry and/or Biology of Proteostasis to Ameliorate Protein Aggregation Diseases
  • Richard Morimoto, Northwestern Univ.  
    The biology of proteostasis in aging and disease
  • Marina Ramirez-Alvarado, Mayo Clinic 
    Systemic misfolding of immunoglobulins in the test tube and in the cell

Communicating Scientific Ideas to Novice Audiences  

  • Paul Craig, Rochester Inst. of Tech.
    Using Molecular Visualization with the Public – Making a Picture = 1000 Words             
  • Nana Lee, Univ. of Toronto
    Using the Three Minute Thesis for Interviews, Outreach and Networking             
  • Arthur Lupia, Univ. of Michigan
    Communicating Science in Politicized Environments             

Discussion Panel: Communicating Scientific Ideas to Novice Audiences  

  • Rachell Booth, Univ. of the Incarnate Word (Moderator)  
  • Paul Craig, Rochester Inst. of Tech.  
  • Nana Lee, Univ. of Toronto  
  • Arthur Lupia, Univ. of Michigan  
  • Marvin Payne, La Sierra Univ.       

Environmental Health, Biomarkers and Precision Medicine presented by the Society for Experimental Biology and Medicine   

  • Ken RamosUniv. of Ariz.
    Precision prevention
  • Ruth Roberts Birmingham Univ.
    Biomarkers and their Impact on Precision Medicine
  • Jennifer WilsonStanford Univ.
    Minimally-invasive biomarkers of neurotoxicity: Application to drug development
  • Stephania Cormier*University of Tennessee Health Sciences Center  
  • Bill Slikker*Food and Drug Administration  

Glycobiology and Functional Glycomics   

  • Markus Aebi, ETH Zürich 
    Precisely heterogeneous - the making of N-glycoproteins 
  • Linda C. Hsieh-Wilson*, Caltech 
    The sweeter side of cell signaling
  • Lara K. Mahal, New York Univ. 
    Decoding glycans: The signal within the noise
  • Natasha Zachara, Johns Hopkins Univ. Sch. of Med. 
    Mapping the O-GlcNAc-Cytoprotective network

New Insights into the Links Between Metabolism and Disease  

  • Lewis C. Cantley*, Weill Cornell Medicine 
    Obesity, insulin resistance and cancer: The PI3K connection
  • Ralph J. DeBerardinis, UT Southwestern Med. Ctr.
    Metabolic reprogramming and its role in causing human diseases
  • Ronald Evans, Salk Inst. HHMI 
    Bert and Natalie Vallee Award in BioMedical Science (2017)
    Corralling pancreatic cancer through epigenetic reprogramming
  • M. Celeste Simon, Univ. of Pennsylvania, Perelman Sch. Of Med. 
    Metabolism, inflammation, and tumor progression

Regenerative Medicine presented by the Society for Experimental Biology and Medicine   

  • Jeffrey D. Macklis, Harvard Univ.  
  • Y. James Kang*, Inst. for Regenerative Med., Sichuan Univ. Med. Sch.
    Vascular tissue regeneration from 3D-bioprinted grafts implanted in Rhesus monkeys
  • Ibrahim Tarik Ozbolat, Pennsylvania State Univ.  
    Intraoperative Bioprinting of Composite Tissues for Craniofacial Reconstruction
  • Gage Crump, University of Southern California  
    Regeneration of Synovial Joints in Zebrafish

RNA in Human Disease  

  • Omar I. Abdel-Wahab, Memorial Sloan Kettering Cancer Ctr.  
    Understanding and targeting spliceosomal gene mutations in cancer
  • Montserrat C. Anguera, Univ. of Pennsylvania, Sch. of Vet. Med. 
    Dynamic mechanisms of Xist RNA localization in female lymphocytes: a new form of X-chromosome Inactivation maintenance
  • Blanton S. Tolbert*, Case Western Res. Univ.
    RNA and RNP Structures that Contribute to Viral Pathogenesis
  • Gene Yeo, UCSD   
    Comprehensive studies of protein-RNA complexes yields insights into neurodegeneration 

Systems Biology and Proteomics  

  • Steven A. Carr, Broad Inst.  
    New approaches for localization of proteins and interaction partners in cells with high spatial resolution
  • Ileana M, Cristea*, Princeton Univ.  
    Hybrid experimental-mathematical methods for understanding dynamic proteome organization during viral infections
  • Kevin White, Univ of Chicago 
    From Petabytes to Molecular Insights: Building an Operating System for Cancer
  • Heng Zhu, Johns Hopkins Univ. Sch. of Med.   
    Virion display (VirD) approach to characterizing non-odorant GPCRs in Humans

Workshop: Molecular Visualization 

  • Jeffrey L. Mills, Rochester Inst. of Tech.
  • Rachel Booth, Univ. of the Incarnate Word 
  • Marvin Payne, La Sierra Univ. 

Tuesday, April 24

Advances in Single Cell Omics  

  • Ibrahim I. Cissé,  MIT 
    Super-resolution imaging of transcription in live mammalian cells
  • James H. Eberwine*, Univ, of Pennsylvania, Perelman Sch. of Med. 
    Multimodal single mouse and human cell 'Omics: Is variability distinct across cellular modalities?
  • Julea Vlassakis, Univ. of California, Berkeley  
    Electrophoretic cytometry: High-selectivity measurement of isoforms using microfluidics
  • Barbara J. Wold, Caltech 
    Single-cell resolution of developing tissues and cell identity programming

Biochemistry of Autophagy and Organelle Trafficking  

  • Kun-Liang Guan*, Univ. of California, San Diego 
    Nutritional regulation of the Hippo pathway
  • James H. Hurley, Univ. of California, Berkeley 
    Initiation, targeting and sculpting of the phagophore
  • Reuben J. Shaw, Salk Inst.  
    AMPK: Mechanisms of cellular energy sensing and restoration of metabolic balance
  • Li Yu, Tsinghua Univ. 
    Migrosome and migrocytosis

Novel Antibiotics and Alternatives presented by the Society for Experimental Biology and Medicine   

  • Dan Hassett*, Univ. of Cincinnati  
  • Daniel Kadouri, Rutgers Univ. of Dental Medicine  
  • Christian Melanderi, North Carolina State University  
  • • Vanessa Sperandio, U.T. Southwestern Medical Center  
    New Drugs for Old Bugs

Plants Do it All     

  • Sean Cutler*, Univ. of California, Riverside 
    Engineering plant signal transduction for water smart crops
  • Beronda L. Montgomery, Michigan State Univ.  
    Spatiotemporal phytochrome-dependent regulation of photosynthesis and growth
  • Elizabeth Sattely, Stanford Univ.  
    Discovery and engineering of plant chemistry for plant and human health
  • Daniel Voytas, Univ. of Minnesota 
    Opportunities afforded by editing the plant genome

Signal Transduction, Pathogenesis and Disease  

  • K. Heran Darwin, New York Univ. Sch. of Med. 
    Proteasomal regulation of hormone signaling in Mycobacterium tuberculosis
  • Tracy Handel, UCSD
    Structure and Signaling Mechanisms of G Protein-Coupled and b-Arrestin-Biased Chemokine Receptors
  • Andrew Kruse, Harvard Med. Sch.  
    New technologies to interrogate G protein-coupled receptor signaling
  • Zhao-Qing Luo, Purdue Univ.  
    Single protein-catalyzed ubiquitination: Chemistry and implications in cell signaling
  • Kim Orth*, UT Southwestern Med.Ctr., HHMI (ASBMB-Merck Award Lecturer)

RNA-mediated Epigenetics   

  • Vahe Bandarian, Univ. of Utah
    Exploring the biosynthesis of hypermodified bases one step at a time
  • Peter Dedon, MIT 
    Beyond the Central Dogma: The tRNA epitranscriptome and an alternative genetic code tune translation during stress in eukaryotes, prokaryotes and viral infections
  • Laurence Ettwiller*, New England Biolabs
    SMRT-Cappable-seq reveals complex operon variants in bacteria
  • Samie Jaffrey, Weill Cornell Med. Col. of Cornell Univ.  
    The dynamic epitranscriptome: Control of mRNA fate and function by nucleotide modifications

Structural Biology presented by the Society for Experimental Biology and Medicine   

  • Tom Thompson*, Univ. of Cincinatti  
  • William Weis, Stanford Univ. 
    Molecular Mechanisms in Wnt Signaling
  • Vince Luca, Moffitt Cancer Center & Research Institute 
  • Joseph Schlessinger, Yale 
  • Mark Lemmon, Yale 

Wednesday, April 25

Biochemical Basis for Epigenetics and Chromatin Remodeling   

  • Benjamin A. Garcia*, Univ. of Pennsylvania Sch. of Med. 
    Quantitative proteomics for understanding the histone code
  • Tatiana Kutateladze, Univ. of Colorado, Denver 
    Reading epigenetic marks
  • Peter Lewis, Univ. of Wisconsin 
    Nucleosome-independent functions for histone H3.3
  • Tom W. Muir, Princeton Univ.
    Painting Chromatin with Synthetic Protein Chemistry

Enzyme Dynamics in Catalysis, Spectroscopy and Theory  

  • Michael D. Fayer, Stanford Univ. 
    Fast dynamics of proteins observed with two dimensional vibrational echo spectroscopy
  • Sharon Hammes-Schiffer*, Univ. of Illinois at Urbana-Champaign 
    Proton-coupled electron transfer in soybean lipoxygenase: Hydrogen tunneling and conformational motions
  • Lewis E. Kay, Univ. of Toronto 
    Seeing the invisible by NMR spectroscopy
  • Christopher Cheatum, Univ. of Iowa 

Metabolomics and Lipidomics   

  • Christian Metallo, Univ. of California, San Diego 
    Exploring links between amino acid and lipid metabolism
  • Daniel Nomura*, Univ. of California, Berkeley 
    Chemoproteomic approaches to map drivers of disease
  • Gary Patti, Washington Univ. at St. Louis 
    Shrinking the metabolome for systems biology
  • Eranthie Weerapana, Boston Coll. 
    Chemical-proteomic strategies to investigate reactive cysteines

Metals in Biology   

  • Michael A. Marletta, Univ. of California, Berkeley 
    Sensing nitric oxide
  • Caryn E. Outten, Univ. of South Carolina 
    Glutaredoxins, glutathione, and iron regulation
  • Amy Palmer*, Univ. of Colrado, Boulder 
    Discovery of new roles for zinc in biology from quantitative mapping of zinc in mammalian cells
  • Eric Skaar, Vanderbilt Univ. Sch. of Med.  
    The struggle for metal at the host-pathogen interface