Spotlight Sessions

The latest research from across the interdisciplinary world of Biochemistry and Molecular Biology is in one place for you to explore. Daily, morning sessions feature invited presentations that will inform and inspire! Click the dates below for speaker details.

Sunday, April 22, 2:30 PM - 3:45 PM

Advanced Biophysical and Biochemical Approaches to Membrane Dynamics (I)  

Session chair: C. Schlieker

  • J. Schöneberg, Univ. of California, Berkeley and Max Planck Inst. of Biophysics, Germany 
    ESCRT Membrane Scission Revealed by Optical Tweezers
  • S. Bahmanyar, Yale Univ. and Yale Sch. of Medicine
    Nano-Scale Size Holes in Er Sheets Provide an Alternative to Tubules for Highly-Curved Membranes
  • T. Galli, Inst. National de la Santé et de la Recherche Médicale (INSERM) U894, Inst. of, France, Inst. Pasteur de Lille, National Ctr. for Scientific Research UMR 8204 - INSERM U1019, Ctr. H, France,  
    Biomechanical Control of Lysosomal Secretion via the Vamp7 Hub: A Tug-of-War Mechanism Between Varp and Lrrk1
  • J. Lawrence, Univ. of California and San Diego 
    The Role of the Escrt Pathway in Prion Disease
  • A. R. Chase, Yale Univ.  
    Dynamic Functional Assembly of the Torsin Aaa+ Atpase and Its Modulation by Lap1: A Novel Mode of Regulation for Aaa+ Atpases

Advances in Mitochondrial Biochemistry

Session chair: E.L. Seifert

  • E.L. Seifert, Jefferson Coll. of Biomedical Sciences
    Loss of Mitochondrial Phosphate Carrier in Skeletal Muscle: Dissociation of Muscle Dysfunction from Lower Adp Phosphorylating Potential
  • M.F. Newhardt, Oklahoma Medical Research Foundation
    Cytoplasmic Pfk-2 Activity Affects Mitochondrial Pdk4 Levels in the Heart
  • B.M. Rabbitts, National Heart, Lung, and Blood Inst., National Inst. of Health, FMP Berlin, Germany and Univ. of Utrecht, Netherlands
    Oxidative Phosphorylation Complex Interactions in Intact Mitochondria
  • M. Noterman, Univ. of Iowa, Weill Cornell Medicine and Cornell Univ.
    The L Type Calcium Channel Cav1.2 Modulates Mitochondrial Calcium Homeostasis and Cell Death
  • F.K. Huynh, Duke Univ. Medical Ctr.
    Sirtuin 4 Controls Leucine Metabolism and Insulin Secretion by Reversing Effects of Reactive Metabolites

Cancer Signaling  

  • F. Rahmatpanah, Univ.of California, Irvine and Medical Univ. of South Carolina
    The Aggressive Nature of Prostate Cancer of African Americans Is Correlated with Massive Down-Regulation of Many Immunoregulatory Genes of Microenvironment
  • S. Dedhar, Univ. of British Columbia, Canada and BC Cancer Research Ctr., Canada
    Limd2 Is an Intracellular Activator of Integrin Linked Kinase(Ilk) Activity and Gsk-3/akt/β-Catenin Signaling
  • M. Mis, Univ. of Toronto, Canada
    A Genome-Wide Crispr-Cas9 Screen Identifies Importin-β11 as a Required Factor for β-Catenin Signaling in Colon Cancer
  • G.A. Arroyo-Martinez, Univ. of Puerto Rico at Ponce, Pontifical Catholic Univ. of Puerto Rico and Univ. of Puerto Rico at Mayagüez
    Effects of Resveratrol in Cell Migration and Invasion by Studying the Cxcr4-Cxcl12 Axis in Breast Cancer Cell Lines
  • J.A. Frost, The Univ. of Texas Health Science Ctr. at Houston
    Regulatory Mechanisms Controlling the Subcellular Localization and Activity of the Rhoa Gef Net1 in Breast Cancer

Glycopolymer Probes  

Session chair: J. Kramer

  • M.E. Griffin, California Inst. of Technology  
    Roles of Glycosaminoglycans in the Ang/Tie Signaling Axi
  • M.L. Huang, Univ. of California and San Diego  
    Harnessing Glycocalyx Interactions to Modulate Differentiation and Development
  • J.A. Taylor, Univ. of Washington, Princeton Univ., Univ. of Delaware, Indiana Univ., Newcastle Univ., United Kingdom and Fred Hutchinson Cancer Research Ctr.  
    Probing the Role of Peptidoglycan Metabolism in Helicobacter Pylori’s Helical Shape
  • G. Hudalla, Univ. of Florida
    Mucus-Inspired Low-Fouling Barriers Based on Self-Assembled Glycopeptide Nanofibers
  • J. Kramer, Univ. of Utah 
    Glycocalyx Engineering with Tunable Synthetic Glycopolypeptides

Herbert Tabor Young Investigator Award Symposium  

Session chair: G. DeMartino

  • C. Back, Univ. of Bristol, United Kingdom and Univ. of Louisville School of Dentistry
    Structural and Functional Studies of the Streptococcal Fibrillar Adhesin Csha
  • N.B. Johnson, Univ. of Wisconsin - Madison
    Sensing Changes in Cellular Iron Metabolism: Regulation of Irp1 by Fbxl5 and Cytosolic Iron-Sulfur Cluster Assembly
  • R.J. Karpowicz, Univ. of Pennsylvania
    Selective Imaging of Internalized Proteopathic α-Synuclein Seeds in Primary Neurons Reveals Mechanistic Insight into Transmission of Synucleinopathies
  • M. F. Lanfranco, Georgetown Univ.
    Asymmetric Configurations in a Reengineered Homodimer Reveal Multiple Subunit Communication Pathways in Protein Allostery
  • K. Ahn, Northwestern Univ. and Thomas Jefferson Univ.
    Complex Interplay of Kinetic Factors Governs the Synergistic Properties of HIV-1 Entry Inhibitors

Motion is Lotion: New Roles of Motion in Enzyme Function

Session chair: J. Hardy

  • J.A. Hayes, Univ. of Massachusetts Medical School and Lawrence Berkeley National Laboratory;
    The Structure and Mechanism of a Viral Genome Packaging Motor
  • R.M. Biondi, IBioBA-CONICET - Partner Inst. of the Max Planck Society, Argentina, Frankfurt Univ. Hospital, Germany and Univ. Col. London, United Kingdom
    Small Compounds Modulating Bi-Directional Allostery in Protein Kinases: A New Grip with an Old Trick
  • J. Hakala, Marquette Univ.
    Investigating Carrier Domain Positioning During Catalytic Turnover in Pyruvate Carboxylase
  • J.A. Hardy, Univ. of Massachusetts Amherst
    Caspase-6 Self-Activation Enables Distinct Helix-Strand Interconversion Upon Substrate Binding
  • C. Clark, The Univ. of Texas at Arlington and North Carolina State Univ.
    Evolution of Caspase Allostery and Enzyme Specificity

Plant Bioactive Natural Products: Discovery, Engineering and Applications

Session chair: L. Hicks

  • L. Hicks, Univ. of North Carolina at Chapel Hill
    Natural Product Bioactive Peptide Discovery Using Pepsavi-Ms
  • S. Loo, Nanyang Technological Univ., Singapore
    Mitochondria-Targeting Peptide from Hibiscus Sabdariffa  
  • R.J. Peters, Iowa State Univ.
    Investigating Gibberellin Phytohormone Biosynthesis by Plant-Associated Bacteria
  • N. Kim, Texas Tech Univ.
    Type III Polyketide Synthase Involved in Tropane and Granatane Alkaloid Biosynthesis
  • I.G. Medina Meza, Michigan State Univ. and Univ. of Michigan
    Montmorency Tart Cherry Anthocyanins: Dose-Dependent Antioxidant Activity Against Cholesterol Oxidation

RNA Recognition and Regulation

Session chair: A. E. Hargrove

  • E. Reister, Univ. of Oregon
    Cisplatin Induces Differential Expression of Snornas and Affects Ribosome Methylation
  • K.N. Busby, Univ. of California and San Diego
    Enzymatic Site-Specific Labeling of RNA for Affinity Isolation of RNA-Protein Complexes
  • C.P. Masamha, Butler Univ. and The Univ. of Texas Medical Branch
    Multiple Mechanisms Driving Alternative Polyadenylation of Cyclin D1 (ccnd1) Pre-mRNA Processing
  • A. Luthra, San Diego State Univ. and Portland State Univ.
    Structure and Mechanism of a Bacterial T6a Biosynthesis System
  • A.E. Hargrove, Duke Univ.
    Small Molecule Differentiation of RNA Structures Using Pattern Recognition
 

Sunday, April 22, 4:00 PM - 5:15 PM

Advanced Biophysical and Biochemical Approaches to Membrane Dynamics (II)  

Session chair: J. Xiao

  • R. Botelho, Ryerson Univ., Canada and McGill Univ., Canada 
    MTor-Dependent Selective Translation Rapidly Expands Lysosome Biogenesis, Volume and Retention Capacity During Phagocyte Activation
  • J.C. Sims, San Francisco State Univ.
    Effects of the Cell Cycle on Vacuole Size in s. Cerevisiae Yeast
  • A. Joiner, Cornell Univ. 
    Deciphering Trapp Complex Function in Yeast
  • G. Wei, Peking Univ., People's Republic of China 
    Myosin IIA Is the Most Important Effector of Zyxin in Camp-Mediated Endothelial Exocytosis
  • J. Xiao, John Hopkins Univ. Sch. of Medicine  
    Spatial Organization of RNA Polymerase in e. Coli Cells

Chemical Biology

Session chair: B. Dickinson

  • Y.Y. Huang, Harvard Univ. and Massachusetts Inst. of Technology
    Anaerobic 4-Hydroxyproline Metabolism by a Widespread Microbial Glycyl Radical Enzyme
  • C.S. de Silva, Univ. of Arizona
    Ligand Gated Split Lysine Acetyl Transferases (KATs) and Kinases
  • C.G. Parker, Scripps Research Institute
    Expanding the Druggable Proteome: Ligand and Target Discovery by Fragment-Based Screening in Cells
  • S. Dodani, The Univ. of Texas at Dallas
    Optical Imaging Tools for Elucidating the Roles of Anions in Cellular Signaling
  • B. Dickinson, Univ. of Chicago
    Chemical Approaches to Probe Signaling by Dynamic Proteome Lipidation

Emerging Perspectives on Metabolism and Cell Fate Decisions  

Session chair: E. Taylor

  • E. Taylor, Univ. of Iowa
    Loss of Mitochondrial Pyruvate Carrier Activity Short Circuits Hepatocellular Tumorigenesis
  • A. Noronha Antony, Thomas Jefferson Univ., Lewis Katz Sch. of Medicine and Temple Univ.
    Fine-Tuning of Hepatocyte Calcium Signaling and Liver Regeneration by the Mitochondrial Calcium Uniporter
  • J. Kim, The Univ.of Texas Southwestern Medical Ctr.
    Unconventional Pathways of Nitrogen Metabolism in Lung Cancer
  • W.A. Houry, Univ. of Toronto, Canada
    Dysregulation of Human Mitochondrial Clpp Protease Activity by Acyldepsipeptides Analogs Leads to Apoptotic Cell Death
  • S. Telang, Univ. of Louisville
    Targeting Glycolytic Metabolism in Cancer

Molecular Chaperones and Protease Systems  

Session chair: A. L. Lucius

  • A.M. Snoberger, West Virginia Univ.;
    Proteasomal ATPases Hard at Work: The Inner Workings of a Protein Destruction Machine
  • C. Kaiser, Johns Hopkins Univ.
    Dual Function of the Trigger Factor Chaperone in Nascent Protein Folding
  • H. Yoo, Univ. of Chicago
    Molecular Chaperones Disperse Pab1 Hydrogel More Quickly Than Misfolded Aggregates
  • W.A. Houry, Univ. of Toronto, Canada
    Dysregulation of Human Mitochondrial Clpp Protease Activity by Acyldepsipeptides Analogs Leads to Apoptotic Cell Death
  • A.L. Lucius, Univ. of Alabama at Birmingham
    Molecular Mechanisms of Enzyme Catalyzed Protein Unfolding and Translocation by Class 1 Aaa+ Motors

Physiological Regulation by Cell Signaling  

Session chair: R. Berdeaux

  • R. Berdeaux, McGovern Medical Sch. at The Univ. of Texas Health Science Ctr.
    Promotion of Muscle Satellite Cell Proliferation by Camp-Induced Transcription
  • B.S. Muntean, Scripps Research Inst. and Florida Atlantic Univ.
    Interrogating Endogenous Neuromodulatory Gpcr Signal Processing by Real-Time Imaging of Camp Dynamics Through Intact Neuronal Circuits
  • A. Jaykumar, The Univ. of Texas Southwestern Medical Ctr. and Georgetown Univ.
    The Function of Wnk1/Osr1 in Cell Migration and Angiogenesis
  • Z.M. Connelly, Louisiana State Univ. Health Sciences Ctr. - Shreveport
    Foxa2 Promotes Prostate Cancer Bone Colonization
  • C.K. Kikani, Univ. of Utah and Fred Hutchinson Cancer Inst.
    Passing on Signals to Compass: A Novel Intramolecular Interactions in Pas Kinase Controls the Stem Cell Fate via Regulating Compass Protein Complexes

Reading, Writing and Erasing Epigenetic Marks

Session chair: C. Chatterjee

  • T-H. Lee, Pennsylvania State Univ.;
    Histone Chaperone Nap1 Facilitates Histone Dynamics in the Nucleosome
  • S. D'Arcy, The Univ. of Texas at Dallas and Fox Chase Cancer Ctr
    Stoichiometry of Multi-Protein Complexes Containing Rtt109, Vps75, and Histone H3-H4
  • B. Fierz, école Polytechnique Fédérale de Lausanne, Switzerland
    Revealing Chromatin State Organization on the Single-Molecule Scale
  • J. Kim, Korea Advanced Inst. of Science and Technology, Republic of Korea
    Biochemical Characterization of the Set1 H3k4 Methyltransferase Complexes
  • C. Chatterjee, Univ. of Washington
    Chemical Tools to Investigate Gene Regulation by Histone Sumoylation

Structure and Mechanisms Regulating RNA Function

Session chair: R. Spitale

  • K. Musier-Forsyth, The Ohio State Univ. and Tufts Univ. Sch. of Medicine
    Probing RNA Structure and Dynamics in the HIV-1 5[prime]utr Using Ensemble and Single Molecule Approaches
  • N. Ayala-Lopez, Yale Univ. and Univ. of Cincinnati
    Role of RNA Binding Protein Rbm15 in M6a RNA Methylation During Megakaryocytic Differentiation
  • S. Obado, The Rockefeller Univ. and Univ. of Dundee, United Kingdom
    Different Classes of RNA Require Distinct Mex67 Paralogs for Processing and Nucleocytoplasmic Export in Trypanosomes
  • H. Shi, The Univ. of Chicago, ShanghaiTech Univ., People's Republic of China, Univ. of Pennsylvania and East China Normal Univ., People's Republic of China
    M6a Facilitates Hippocampus-Dependent Learning and Memory Through Ythdf1
  • R. Spitale, Univ. of California and Irvine
    Chemo-Transcriptomic Methods to Measure RNA Structure Inside Living Cells
 

Sunday, April 22, 4:15 PM - 5:15 PM

BMB Professional Development: Advancing Successful Careers  

Session chair: R. Booth

  • D.E. Rhoads, Monmouth Univ.
    Leadership Skill Development in an Undergraduate Biochemistry Lab
  • K.K. Resendes, Westminster Col.
    Effects of a Data Analysis Intensive Course on Student Critical Thinking Skills, Confidence, and Post-Graduation Success
  • J. Baumgartner, San Francisco State Univ.
    Graduate Student Professional Development and a Cure-Style Course and Peer-Reviewed Student Publications
  • Y. Dobrydneva, George Washington Univ. Sch. of Medicine and Health Sciences
    Predictors of Success on the Mcat for Post-Baccalaureate Pre-Medicine Students
 

Monday, April 23, 2:30 PM - 3:45 PM

Chromatin Regulation of Gene Expression  

Session chair: V. M. Weake

  • P. Grant, Univ. of Virginia Sch. of Medicine
    Elucidating Epigenetic Readers of H3t45ph in s. Cerevisiae  
  • D. Steger, Univ. of Pennsylvania
    Determining the Enhancer Proteomes in Primary Cells and Native Tissue
  • S.S. P. Rao, Stanford Univ., Baylor Col. of Medicine, Broad Inst. of Massachusetts Inst. of Technology and Harvard, Lymphocyte Nuclear Biology, National Inst. of Arthritis and Musculoskeletal and Skin Diseases, N and New York University
    Cohesin Loss Eliminates All Loop Domains
  • B.C. Smith, Medical Col. of Wisconsin
    Discovering and Exploiting Selectivity in BET Tandem Bromodomain Recognition of Epigenetic Lysine Acylation
  • V.M. Weake, Purdue Univ.
    Aging Photoreceptors: Light, Stress and Transcription

Emerging Antibiotics from Nature

Session chair: T. Wencewicz

  • A.E. Robinson, Washington Univ. Sch. of Medicine in St. Louis
    Ni(II) Uptake by Yersiniabactin, a Metallophore Produced by Uropathogenic e. Coli
  • K.M. Hoffmann, California Lutheran University
    Structural and Functional Large Substrate Binding in Iterative Non-Ribosomal Peptide Synthesis Independent Synthesis (NIS) Enzymes
  • V. Vinnik, Univ. of Wisconsin - Madison
    Directed Evolution of an Adenylation Domain Specificity Code
  • V. Agarwal, Georgia Inst. of Technology
    Synthetic Biology, Biosynthesis, Enzymology, (Meta)genomics, et al. Learning from Nature
  • T. Wencewicz, Washington Univ. in St. Louis
    Beta-Lactam and Beta-Lactone Antibiotics from Plant Microbiomes

New Frontiers in Substrate Metabolism

Session chair: L. Kazak

  • L. Kazak, McGill Univ., Canada and Dana-Farber Cancer Inst.
    Mechanism of Obesity Suppression by Adipose Tissue Creatine Energetics
  • A.J. Lutkewitte, Washington Univ. Sch. of Medicine in St. Louis and Ionis Pharmaceuticals Inc.
    Mogat1 Is a Fasting-Induced PPAR α Target Gene That Plays a Role in Coordinating the Hepatic Response to Food Deprivation
  • L. Zhao, Univ. of North Carolina at Chapel Hill
    Deletion of Muscle Acsl1 Caused Myopathy and Fiber Switch
  • L.M. Paolella, Univ. of Pennsylvania
    Mtor Signaling in Adipose Tissue Influences Systemic Lipid Metabolism
  • M. Wallace, Univ. of California, San Diego, Univ. of California, Berkeley and Salk Inst.
    Monomethyl Branched Chain Fatty Acids Link Mitochondrial Amino Acid Metabolism and Adipose Tissue Lipogenesis to Fatty Acid Diversity

Plant Metabolism and Photosynthesis

Session chair: J. C. Cameron

  • J.C. Cameron, Univ. of Colorado Boulder
    Exploring the Regulation of Photosynthesis in Single-Cell Lineages at Sub-Cellular Resolution
  • A.L. Smythers, Marshall Univ.
    Effects of a Sethoxydim-Based Herbicide on the Photosynthetic Capacity of Chlorella Vulgaris, a Non-Target Organism
  • P. Fan, Michigan State Univ.
    The Rising of Acylsugar Diversity: Metabolic Innovation in Tomato Trichomes Through Bahd Enzyme Promiscuity and Pathway Evolution
  • X. Mao, Purdue Univ.
    Investigating the Interaction Between Med5 and Cdk8 in Arabidopsis
  • Z. Ghalamkari, Humboldt Universität zu Berlin, Germany
    Increasing Seed Iron Content by Gene Manipulation in Arabidopsis

Protein Folding: The Good, the Bad and the Disordered

Session chair: J. E. Kim

  • B.A. Barry, Georgia Inst. of Technology
    The Intrinsically Disordered PsbO Subunit of Photosystem II: Structure and Role in Photosynthetic Water Oxidation
  • N. Cohen, Univ. of Massachusetts Medical Sch.
    Non-Native Structure Present in the Unfolded Ensemble May Initiate Aggregation of Als Variants of Superoxide Dismutase (Sod1)
  • R. Levenson, Univ. of California and Santa Barbara
    Initially Disordered, Reflectin Assembly Tunably and Reversibly Drives Biophotonic Color
  • J. Radoicic, Univ. of California and San Diego
    Nmr Structural Studies of Membrane Proteins in Bilayer Environments
  • D.K. Asamoto, Univ.of California and San Diego
    Folding of a Membrane Protein into Nanodiscs

Proteomics and Lipidomics: Methods and Applications for Human Disease

Session chair: A. Nita-Lazar

  • A. Nita-Lazar, National Inst. of Allergy and Infectious Diseases and National Inst. of Health
    Targeted Proteomics-Driven Computational Modeling of Macrophage Microbial Sensing Pathways
  • A. Salomon, Brown Univ.
    Quantitative Phosphoproteomic Analysis of Feedback Networks in T Cell Signaling
  • E. Levy, Northeastern Univ. and Harvard Univ.
    Mass Spectrometry of Single Mammalian Cells Quantifies Proteome Heterogeneity During Cell Differentiation
  • J.R. Daniels, National Ctr. for Toxicological Research, U.S. Food and Drug Administration and Metanomics Health GmbH, Germany
    An Aptamer-Based Approach to Assess the Human Plasma Proteome for Pre-Analytical Variability
  • E. Berdyshev, National Jewish Health
    Advancement in Atopic Dermatitis Research Through the Use of a Novel Skin Tape Strip Mass Spectrometry Based Processing Protocol

Redox Enzymes

Session chair: K. Johnson-Winters

  • A.B. Dumbrepatil, Univ. of Michigan
    A Novel Radical SAM Mechanism Mediated by the Interferon-Inducible Protein Viperin
  • K. Johnson-Winters, The Univ. of Texas at Arlington and Univ. of Auckland, New Zealand
    Determining the Active Site Base and Order of Substrate Addition Within F420-Dependent Glucose-6-Phosphate Using Steady-State and Pre Steady-State Kinetics and Isotope Effects Methods
  • J. Mattice, Montana State Univ. and Washington State Univ.
    A Bacterial Flavin-Dependent Oxidoreductase That Captures Carbon Dioxide into Biomass
  • C.A. Khan, The Univ. of Texas Health Science Center and Princeton Univ.
    Dissecting the Molecular Basis of a Phenylketonuria-Causing Mutation in Phenylalanine Hydroxylase
  • E. Roussarie, National Ctr. for Scientific Research, France
    Deciphering the Effect of Salts on Bilirubin Oxidases Activity
 

Monday, April 23, 4:00 PM - 5:15 PM

BMB Education: Active Learning  

Session chair: M. Payne

  • M.A. Rowland-Goldsmith, Chapman Univ.
    Using an Innovative Approach to Teach Students How to Communicate About Scientific Topics to Non-Scientists
  • D.P. Grilley, Univ. of Wisconsin - La Crosse
    Scaffolding Soft-Skill Development Into a Two-Semester Undergraduate Laboratory Course
  • L.J. Moore, Monmouth Col.
    Increasing Active Learning in the Biochemistry Classroom: Using Group Quizzes to Stimulate Discussion
  • S.M. Lo, Univ. of California and San Diego
    When Active Learning Fails: How Faculty Beliefs Inform Their Teaching and Influence Student Outcomes
  • D.R. Dries, Juniata Col., Univ. of Saint Joseph, Milwaukee Sch. of Engineering, Col. of St. Benedict/St. John's Univ., Wabash Col., MinorityPostdoc.org and Univ. of Minnesota Rochester
    A Competency-Based Approach to Developing Biomolecular Visual Literacy

DNA Replication Initiation, Progression and Termination

Session chair: D. Smith

  • J.A. Stewart, Univ. of South Carolina
    A Novel Role of the Human Cst Complex in Regulating the DNA Damage Response
  • N. Kim, The Univ. of Texas Health Science Ctr. at Houston
    The Highly Conserved Proteins Nucleolin and Sub1 Play Critical Roles in Regulating G4 DNA-Induced Genome Instability
  • G.W. Brown, Univ. of Toronto, Canada and International Foundations of Medicine, Italy
    Rad5 Prevents the Accumulation of ssDNA Gaps at Stressed DNA Replication Forks
  • P.N. Pozo, Univ. of North Carolina at Chapel Hill
    Cdt1 Variants Offer Novel Insights into Cdt1-Mcm Interactions and an Unexpected Mechanism for Cyclin A to Block DNA Re-Replication
  • W. Chai, Washington State Univ.
    Molecular Insights into Replication-Associated Genome Instabilities Caused by CST Deficiency

Glycoimmunity

Session chair: C. L. Leimkuhler-Grimes

  • Y. Shen, ETH Zürich, Switzerland, Centro de Investigaciones Biológicas, Spain and Faculdade de Medicina Universidade de Lisboa, Switzerland
    Molecular and Structural Recognition of Listeria Cell-Wall Glycopolymers by Bacteriophage-Encoded SH3b Domains
  • N. Khan, Univ. of California, San Diego, Univ. of Adelaide, Australia and La Trobe Univ., Australia
    Rapid Evolution of Bacterial Exotoxin B Subunits Independent of a Subunits: Sialic Acid Binding Preferences Correlate with Host Range and Intrinsic Toxicity
  • M. Machacek, Univ. of Kansas Medical Center and Michigan State Univ.
    Elevated O-Glcnac Exacerbates Pro-Inflammatory Cytokine Secretion from Cd4+ T Cells
  • N. Lanz, U.S. Food and Drug Administration
    Role of the Kdo Glycosyltransferase Kpss in the Biosynthesis of the Polysialyltransferase Acceptor for escherichia Coli K1
  • K.M. Lazor, Univ. of Delaware
    Use of Bioorthogonal N?acetylcysteamine (SNAC) Analogues and Peptidoglycan O?acetyltransferase B (PatB) to Label Peptidoglycan

Lipid and Protein Organization in Membranes

Session chair: S. L. Veatch

  • B.C. Allen, Monmouth Col.
    Brewster Angle Microscopy and Langmuir Monolayer Films: Construction of an Instrument and Basic Software Development for Visualization of Lipid Domains and Lipid Raft Formation
  • A.R. Naik, Wayne State Univ., Univ. of Bristol, United Kingdom and Univ. of Vermont
    Mechanism of Membrane Biogenesis
  • A. Mizuike, The Univ. of Tokyo, Japan and Chubu Univ., Japan
    Regulating a G Protein-Coupled Receptor by Topological Inversion Through Regulated Alternative Translocation
  • B. Denard, The Univ. of Texas Southwestern Medical Ctr.
    Regulating a G Protein-Coupled Receptor by Topological Inversion Through Regulated Alternative Translocation
  • S.L. Veatch, University of Michigan
    Probing Membrane-Mediated Forces Between Proteins in Cells Using Super-Resolution Fluorescence Localization Imaging

Molecular Tools to Study Cell Signaling

Session chair: M. Tantama

  • M. Tantama, Purdue Univ.
    Revealing Subcellular Redox Dynamics with Multiplex Imaging of Compartment-Specific Redox Probes
  • X. Zhou, Univ. of California and San Diego
    Spatial Compartmentalization of Akt/mtor Signaling: What Happens in the Nucleus
  • P. Mondal, Univ. of Illinois at Urbana-Champaign
    Temporal Control of Growth Factor-Mediated Signaling Pathways During Cell Differentiation and Xenopus Embryonic Development
  • M. Shaaya, Univ. of Illinois at Chicago and Georgia Inst. of Technology
    Allosteric Regulation of Protein Kinases Using Optogenetics
  • C.A. Thorne, Univ. of Arizona, Univ. of California, San Francisco and The Univ.of Texas Southwestern Medical Ctr.
    Planar Enteroids Reveal an Autonomous Wnt and Bmp Circuit Controlling Intestinal Epithelial Growth and Organization

Obesity, Metabolism and Immune Cells in Cancer

Session chair: L. Makowski

  • A. Kennedy, Vanderbilt Univ. Seattle Children's Hospital and Vanderbilt Univ. Medical Ctr.
    Cd8+ T Cells Regulate Liver Injury in Obesity-Related Nonalcoholic Fatty Liver Disease
  • T. Roy Sarkar, Texas A&M Univ. and Independent Researcher, United Kingdom
    The Role of Effective Energy Restriction on Metastatic Tumor Growth
  • M. Das, Univ. of California and San Diego
    Time-Restricted Feeding Attenuates Breast Cancer Growth in a Mouse Model of Postmenopausal Obesity
  • H. Cai, Univ. of Georgia
    Biosynthesis of Acyl-Coas Sustains Prostate Cancer Progression
  • A. Fuller, Univ. of North Carolina and Univ. of Tennessee Health Science Ctr.
    Myeloid-Specific Glut1 Ablation Attenuates Mammary Gland Inflammation and Claudin-Low Breast Cancer Progression

Strange Microbial Transformations

Session chair: M. R. Seyedsayamdost

  • B. Li, Univ. of North Carolina at Chapel Hill
    Biosynthesis of Nonproteinogenic Amino Acids Oxyvinylglycines
  • A.I. Celis, Montana State Univ. and Vanderbilt Univ. Medical Center
    Evidence for Control of Metabolite Flux Through a Bacterial Heme Biosynthetic Pathway
  • M. Freeman, Univ. of Minnesota
    New RiPP Family Incorporates Alpha-N-Methylations into Ribosomally Encoded Peptide Natural Products
  • J. Schaffer, Washington Univ. in St. Louis
    Biosynthesis of Non-Ribosomal Peptide Beta-Lactones by Plant-Associated Pseudomonas Fluorescens
  • M.R. Seyedsayamdost, Princeton Univ.
    Eliciting Cryptic Secondary Metabolites Using Antibiotics
 

Tuesday, April 24, 2:30 PM - 3:45 PM

DNA Damage and Repair  

Session chair: D. Wang

  • O. Adebali, Univ. of North Carolina at Chapel Hill
    High-Resolution Maps of Genome-Wide Human Damage and Repair
  • K. Myka, Columbia Univ., Department of Microbiology and Immunology
    A New Pathway of Transcription-Coupled Repair
  • B.F. Eichman, Vanderbilt Univ.
    Base Excision Repair of DNA Interstrand Crosslinks
  • M.L. Bochman, Indiana Univ.
    RecQ4 Helicases Stimulate Nuclease Activity During DNA Inter-Strand Crosslink Repair
  • D. Wang, Univ. of California and San Diego
    Molecular Mechanism of Transcription Transcription-Coupled Repair

Mechanisms of G Protein Signaling

Session chair: A. M. Lyon

  • M. Schaid, Univ. of Wisconsin - Madison
    Coordinated Cross-Talk Between Calcium and Camp in Regulating Pulsatile Insulin Secretion: A Novel Role for the Unique Inhibitory G-Protein, Gαz ,in Regulating β-Cell Function
  • C. Williams, Medical Coll. of Wisconsin
    New Insights into the Role of Smggds as a Major Integrator of Signaling by Ras and Rho Family Members in Cancer
  • M. Torres, Georgia Inst. of Technology
    Phosphorylation of G Protein γ Subunit Ste18 and the Ste5 Scaffold Form a Braking System that Governs Pathway Activation Kinetics and Switch-Like Signaling in Yeast
  • N. Bawazir, Univ. of the Sciences
    Plasma Membrane Pi(4,5)p2 Threshold Regulates Chemotactic Signaling Pathways and Cell Morphology
  • A. Lyon, Purdue Univ.
    Conformational Regulation of Phospholipase C Enzymes

Membrane Lipid Biochemistry

Session chair: J. Burke

  • R. Blind, Vanderbilt Univ.
    Crystallographic and Enzyme Kinetic Analyses of the Human Inositol Polyphosphate Multikinase (IPMK)
  • M. Airola, Stony Brook Univ.
    Structure and Function of Lipins: Key Enzymes in Triglyceride Metabolism
  • A. Grabon, Texas A&M Univ.
    A Novel Multi-Domain Phosphatidylinositol Transfer Protein/Oxysterol Binding Protein Senses Specific Phosphoinositide Pools on Toxoplasma Dense Granules
  • B. Goulden, Univ. of Pittsburgh
    Novel Biosensors for an Enigmatic Phosphoinositide
  • S. Endapally, The Univ. of Texas Southwestern Medical Ctr.
    Sphingomyelin-Cholesterol Complexes in Plasma Membranes

Metabolic Reprogramming

Session chair: J. Ellis

  • R.K. Singh, Weill Cornell Medicine and Cornell Univ.
    Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL Uptake and Catabolism
  • M. C.B. Ammons, Idaho Veterans Research and Education Foundation and Montana State Univ.
    Metabolic Reprogramming of Macrophages Exposed to Pseudomonas Aeruginosa Biofilm
  • L.R. Perazza, Laval Univ., Canada and Sherbrooke Univ., Canada
    Distinct Roles of Dietary Fat and Sugar in the Development of Obesity, Insulin Resistance, Atherosclerosis and Cardiac Dysfunction in Ldl Receptor Knockout Mice
  • Z. Yang, Univ. of Connecticut
    Long Non-Coding RNA H19 Serves as a Lipid Sensor to Reprogram Hepatic Lipid and Glucose Homeostasis by Interaction with RNA Binding Protein Ptbp1
  • M. Clark, Inst.of Medicine, Univ. of Gothenburg, Sweden, Department of Cell and Molecular Biology, Uppsala Univ., Sweden, Insti. of Clinical Sciences and Univ. of Gothenburg, Sweden
    Impact of Short- and Long-Term Weight Loss on the Inflammatory Profile of Metabolically Healthy and Unhealthy Obese Patients

Metals in Biology

Session chair: A. E. Palmer

  • S. Hardy, McGill Univ., Canada
    PRL Phosphatases Promote Tumor Progression by Regulating the Level of Intracellular Magnesium
  • S.M. Damo, Fisk Univ. and Vanderbilt Univ.
    Zinc-Mediated Oligomerization of S100a12
  • E. Yukl, New Mexico State Univ. and Reed Col.
    Heme-Free H-Nox from Vibrio Cholerae Is Activated by Oxidation via a Zinc Ligand Switch Mechanism
  • R.E. Cowart, Univ. of Dubuque and Lindenwood Univ.
    ATP as an Allosteric Modulator and Chelator of Fe3+ from Fe3+-Transferrin Is ATP a Major Fe3+ Carrier
  • J. Hu, Medical Univ. of South Carolina
    A New Membrane Potential (δψ)-Independent Iron Indicator Selectively Detects Mitochondrial Chelatable Iron but Not Calcium in Living Cells

Protein Folding: Every Which Way but Loose

Session chair: J. E. Kim

  • Y. Liu, Pennsylvania State Univ.
    Modulation of Fluorescent Protein Chromophore to Detect Protein Aggregation
  • A. Gräslund, Stockholm Univ., Sweden
    The Amyloid-β Peptide in Alzheimer's Disease: Molecular Interactions and Structure Conversions
  • Y. Shaul, Weizmann Inst. of Science, Israel
    The Disordered Landscape of the 20s Proteasome Substrates and the Mechanism of Their in Vitro and in Vivo Degradation
  • S. Park, Univ. of Colorado Boulder
    A Nucleotide-Dependent Switch in Proteasome Assembly Mediated by the Nas6 Chaperone
  • M.M. Hopkins, Univ. of Colorado Anschutz Medical Campus
    Biophysical Analysis of Human Neuropeptide Y: Mutations in the Hairpin Core Reveal Unusual Thermal Stability Linked to Higher-Order Self-Association

Structure and Mechanism in Natural Product Biosynthesis Enzymes

Session chair: A. K. Boal

  • L.M. K. Dassama, Boston Children's Hospital, Dana-Farber Cancer Inst., and Harvard Medical Sch. and Northwestern Univ.
    Transport and Synthesis of a Bacterial Natural Product
  • M.D. DeMars, Univ. of Michigan, Univ. of California, Los Angeles, Univ. of California and San Diego
    Comparative Analysis of Bacterial Cytochromes P450 Involved in the Biosynthesis of 16-Membered Ring Macrolide Antibiotics
  • K.M. Davis, Princeton Univ.
    Structural Insights into Peptide Recognition and Modification by the Radical SAM Enzyme SuiB
  • J. Bridwell-Rabb, Univ. of Michigan, The Univ. of Texas and Massachusetts Inst. of Technology
    Biosynthesis of Oxetanocin: Are Two Cofactors Better Than One?
  • A.K. Boal, Pennsylvania State Univ.
    A Crystallographic View of the Reaction Cycle in Iron(II) and 2-(Oxo)-Glutarate-Dependent Oxygenases

Tools for Exploring Glycobiolgy

Session chair: K. Godula

  • K. Godula, Univ. of California and San Diego
    Engineering Synthetic Glycan Co-Receptors Into the Glycocalyx of Muscle Cells to Control Early Stages of Neuromuscular Junction Development
  • A. Sasmal, Univ. of California and San Diego
    Encoding and Estimating the Remarkable Diversity of Possible Sialyltrisaccharides in Nature
  • M. Barboza, Univ. of California and Davis
    System Metaglycomes: Mapping Dynamic Cell Surface N-Glycome, O-Glycome and Glycolipidome by Mass Spectrometry
  • L. Yang, Lectenz Bio and Univ. of Georgia
    Glycosensetm: A Rapid Method for Monitoring in Vitro Glycoengineering
  • K.E. DeMeester, Univ. of Delaware, Fred Hutchinson Cancer Research Ctr and Univ. of Massachusetts Amherst
    Synthesis of Bioorthogonal Muramyl Glycans That Illuminate and Track Bacterial Peptidoglycan
 

Tuesday, April 24, 4:00 PM - 5:15 PM

Cell Stress, Autophagy and Mitophagy  

Session chair: F. Zhang

  • S.N. Dumas, Univ. of Wisconsin - Madison
    Il-6 and Bile Acids Are Skin-Derived Factors That Regulate Whole-Body Metabolism in SCD1 Deficient Mice
  • F. Zhang, Univ. of Miami
    Posttranslational Arginylation Enzyme Ate1 Is a Mitochondrial-Derived Master Regulator That Coordinates Glycolysis and Respiration in the Warburg Effect
  • V.D. Bhatt, Rutgers Univ.
    Autophagy Modulates Lipid Metabolism to Support Liver Kinase B1 (Lkb1)-Deficient Lung Tumor Growth
  • D. Puckett, Univ. of Tennessee and Knoxville
    Zyflamend Induces Apoptosis in Pancreatic Cancer Cells via Modulation of Endoplasmic Reticulum Stress and Autophagy
  • X. Liu, West China Hospital and Sichuan Univ., People's Republic of China
    Oleic Acid Protected Pancreatic β-Cell Against Saturated Fatty Acid Induced Lipotoxicity

Chromatin, Replication and Repair

Session chair: S. Forsburg

  • S. Forsburg, Univ. of Southern California
    Heterochromatin Proteins Influence the Choice of DNA Repair in Euchromatin Domains
  • P. Bu, St. John's Univ.
    Rad53p Activation Alters Chromatin Structure, Induces Respiration and Elevates Cellular Atp Level
  • M. Wu, Brigham and Women's Hospital and Harvard Medical Sch., Johns Hopkins Univ. Sch. of Medicine and Univ. of Leicester, United Kingdom
    Analysis of Corest Complex-Chromatin Interactions with Chemical Tools
  • Z. Yuan, Van Andel Inst. and Rockefeller Univ.
    Structure of Eukaryotic Cmg Helicase at a Replication Fork and Implications for Replisome Architecture and Origin Initiation
  • D. Smith, New York Univ.
    Deconstructing Lagging-Strand Synthesis in Vivo

Engineering Biology

Session chair: A. Chatterjee

  • A. Mehta, Scripps Research Inst. and The Genomics Inst. of the Novartis Research Foundation
    Engineering Yeast Endosymbionts as a First Step Towards Laboratory Evolution of Mitochondria
  • A.C. Komor, Univ. of California and San Diego
    Base Editing: Chemistry on the Genome
  • J. Yin, Georgia State University
    Identifying the Substrate Proteins of E3 Ubiquitin Ligase by Orthogonal Ubiquitin Transfer (OUT)
  • D. Chou, Univ. of Utah
    Mini-Ins: A Monomeric Human Insulin Inspired from Cone Snail Venom Peptides
  • A. Chatterjee, Boston Coll.
    Development and Applications of Universal Platforms for Genetic Code Expansion

High-throughput Methods for Connecting Transcriptomes, Proteomes, and Secretomes

Session chair: S. Zhong

  • K. Johnson, Univ. of California and San Diego
    A System for Global Analysis of Correlation Between Protein Expression and mRNA
  • S. Ramadan, Weill Cornell Medicine-Qatar, Qatar
    Interactome Mapping of the Pathogen Helicobacter Pylori Using All-vs-All Sequencing (Ava-Seq)
  • N. Lewis, Univ. of California and San Diego
    Genome-Scale Reconstructions of the Mammalian Secretory Pathway Predict Metabolic Costs and Limitations of Protein Synthesis and Secretion
  • J.H. Wissler, ARCONS Inst. for Applied Research and Didactics, Germany
    Functional Somatic Noncoding ncRNA of Extracelular Vesicles (EV) for Vascular Epigenetics: A Genomic Crossword Puzzle in Adaptation of Cells Under Stress
  • N. Huang, Univ. of California and San Diego
    Localized Single Transcript Detection of EML4-ALK in NSCLC Using Co-Localization Quantum Dot Fluorescent in Situ Hybridization (Coqfish)

Molecular Basis of Signaling

Session chair: K. Gehring

  • K. Gehring, McGill Univ., Canada
    Regulation of Mitophagy by the Parkin Ubiquitin Ligase and Pink1 Ubiquitin Kinase
  • J. Callender, Univ. of California, San Diego, Cancer Research UK Manchester Inst., United Kingdom, National Cancer Inst. at Frederick and National Inst. of Health
    Protein Kinase Cα (PKCα) Gain-of-Function Variant in Alzheimer[rsquo]s Disease Displays Enhanced Catalysis by a Mechanism That Evades Down-Regulation
  • S. Korolev, Saint Louis Univ. School of Medicine
    Novel Crystal Structure of Calcium Independent Phospholipase Ipla2β: Mechanism of Activity Regulation and Membrane Localization
  • K. Hsu, Univ. of Virginia
    Chemoproteomic discovery of ligand binding hotspots in the lipid kinome.
  • G. Hammond, Univ. of Pittsburgh
    Sac1 Degrades Its Lipid Substrate Ptdins4P in the Er to Maintain a Steep Electrochemical Gradient on Donor Membranes

Nutrition, Genetics and Metabolism

Session chair: C-L. E. Yen

  • D.W. Lamming, Univ. of Wisconsin - Madison
    Decreased Consumption of Specific Dietary Macronutrients Restores Metabolic Health to Diet-Induced Obese Mice
  • B.W. Parks, Univ. of Wisconsin - Madison
    Leveraging Mouse Liver Co-Expression Networks and Human Lipid GWAS Data to Identify and Validate Cholesterol Metabolism Genes
  • M.J. Berry, Univ. of Hawaii
    Selenium and Sex: Competition Between Brain and Testes for Selenium Results in Male-Specific Consequences in Mice and Men
  • J.M. Ellis, Purdue Univ. and Univ. of California
    Long-Chain Acyl-CoA Synthetase 6 Deficiency Reduces the Omega-3 Fatty Acid DHA in the Brain and Disrupts Motor Control
  • C-L E. Yen, Univ. of Wisconsin - Madison
    Triacylglycerol Synthesis, Energy Metabolism, and Glucose Homeostasis: A Gut Reaction?

Ribosomes and Translational Regulation

Session chair: H. Jin

  • S.J. Baserga, Yale Univ. Sch.of Medicine, Yale Sch. of Medicine and National Inst. of Environmental Health Sciences, National Inst. and Yale West Campus
    High Throughput Discovery of Novel Regulators of Human Ribosome Biogenesis
  • G. Brar, Univ. of California, Berkeley and Columbia Univ.
    Pervasive, Coordinated Protein Level Changes Driven by Transcript Isoform Switching
  • M.K. Holz, Yeshiva Univ.
    Regulation of Protein Translation Initiation by Estrogen
  • S. Vasudevan, Massachusetts General Hospital and Harvard Medical School and Brigham and Women's Hospital
    A Post-Transcriptional Program of Chemoresistance Regulators in Quiescent Cancer Cells
  • K.M. Hamadani, California State Univ. and San Marcos
    Novel in-Vitro Tag-and-Modify Protein Sample Generation Methods for Multiplexed Single-Molecule Fret Screening