Issues in Depth: Antibiotics and Antibiotic Resistance

Issues in Depth is a series of symposia focused this year on antibiotics and antibiotic resistance. The series is sponsored by the ASBMB Minority Affairs Committee.

Sunday, April 23

New Approaches for Antibiotic Discovery
10:00 a.m. - 12:00 p.m., McCormick Place, W185bc
Chair: Alexander S. Mankin, University of Illinois at Chicago

  • 10:00 a.m      Eric J. Brown, Genentech, Antibody-antibiotic conjugates: a new platform for treatment of serious bacterial infections
  • 10:30 a.m.     Timothy Lu, Massachusetts Institute of Technology, Combating Antibiotic Resistance with Genetically Engineered Therapeutics
  • 11:00 a.m.     Eric Brown, McMaster University, To kill a bacterium, you need to think like a bacterium
  • 11:30 a.m.     Magda Barbu, Synthetic Genomics Vaccine, Inc., Engineered bacteriophage therapeutics against multidrug-resistant pathogense     

Monday, April 24

New Insights into Mechanisms of Antibiotic Action
10:00 a.m. - 12:00 p.m., McCormick Place, W185bc
Chair: Eric Brown, McMaster University

  • 10:00 a.m.     Peter Belenky, Brown University, Bacterial metabolism and antibiotic efficacy
  • 10:30 a.m.     Kim Lewis, Northeastern University, Antibiotics from the microbial dark matter
  • 11:00 a.m.     Martin Schmeing, McGill University, Structures and functions of nonribosomal peptide synthetases, natural antibiotic factories
  • 11:30 a.m.     Nora Vazquez-Laslop, University of Illinois at Chicago, Context-specific action of ribosomal antibiotic

Tuesday, April 25

Antibiotic Resistance
10:00 a.m. - 12:00 p.m., McCormick Place, W185bc
Chair: Kim Lewis, Northeastern University    

  • 10:00 a.m.     Gautam Dantas,  Washington University School of Medicine, Networks of exchanging antibiotic resistance between environmental, commensal, and pathogenic microbes
  • 10:30 a.m.     Ken Gerdes, University of Copenhagen, Remarkable functional convergence: Type I and II toxin-antitoxins induce multidrug tolerance by (p)ppGpp-dependent mechanisms
  • 11:00 a.m.     Deborah T. Hung, Harvard University and Massachusetts General Hospital, Exploiting chemical genetics to combat infections  
  • 11:30 a.m.     Joao Xavier, Memorial Sloan Kettering Cancer Center, Modeling the gut microbiota with mathematical ecology    

NIH Funding Opportunities Workshop
12:30 p.m. - 2:00 p.m., McCormick Place, W185bc 

  • 12:30 p.m.     Tina Guina, NIAID and Anita Sheoran, NIAID, Funding the antibacterial research and Carb-x Initiative
    • NIAID-funded programs help facilitate translation of basic research discoveries from “bench to bedside”.
    • Attendees will learn about NIAID programs that support productdevelopment, including preclinical services for development of antibacterialtherapeutics, vaccines, and diagnostics, and CARB-X initiative.  
    • NIAID goal is to boost the pipeline of new products to mitigate and prevent upsurge in resistant infections.
  • 12:50 p.m.     Austin Yang, National Institute of Aging, Etiology and Treatment of Alzheimer’s Disease   
  • 1:05 p.m.     Pamela Marino, National Institute of General Medicine,  NIGMS Programs and the NIH Common Fund    
  • 1:20 p.m.     Q&A