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Effect of H-bond donor lipids on (PI(3,4,5)P3) ionization and clustering

March 2018 | A new paper by the Kooijman lab at Kent State University is out in the Biophysical Journal. “Sometimes we take for granted how mixed lipid systems can alter the ionization and clustering of other lipids,” ASBMB Lipid Research Division co-chair Rob Stahelin of Purdue University said. “This is a great article on how phosphatidylethanolamine and phosphatidylinositol influence the ionization state of the signaling lipid PIP3.”
Read the paper by Graber et al.

  

PKM2 activates nuclear SREBP-1a

March 2018 | SREBPs stimulate lipid biosynthesis through transcriptional activation of lipogenic enzymes, but their roles and interaction partners in cancer cells are not well understood. Here, Zhao et al. shed light on dysregulated lipid metabolism in cancer cells by discovering an interaction between pyruvate kinase M2 and nuclear SREBP1a.
Read the article in the Journal of Biological Chemistry.

  

From the unfolded protein response to metabolic diseases

February 2018 | This review from the Thibault lab at Nanyang Technological University in Singapore covers the exciting finding that the unfolded protein response, an endoplasmic reticulum response to stress, can be triggered by lipid dysregulation. What are the mechanisms for lipid dysregulation sensing?
Read the review by Ho et al. in the Journal of Cell Science.

  

Toward a harmonized field of lipidomics

December 2017 | John Bowden of the National Institute of Standards and Technology talks about a recent paper reporting an exercise to measure the reproducibility of lipidomics analyses across 31 labs in the U.S. and abroad.
Read the Q&A with Bowden in ASBMB Today.

  

The polybasic domain determines lipin phosphoregulation

October 2017 | Lipins are unusual among glycerolipid synthase enzymes because they are not embedded in the endoplasmic reticulum membrane but can transfer between the cytosol and the ER membrane. Researchers in the Harris lab at the University of Virginia investigated why lipin 1 is regulated by phosphorylation but lipin 3 is not.
Read about the work in this “Lipid News” article by Salome Boroda and Thurl Harris in ASBMB Today.

  

PAP controls expression of PSS for phospholipid synthesis

September 2017 | Phosphatidate phosphatase, encoded by the gene PAH1, regulates membrane growth, and, through it, cellular growth capacity. The Carman lab at Rutgers University investigated how PAP affects the expression and activity of other enzymes involved in phospholipid synthesis.
Read the article by Gil-Soo Han and George M. Carman in the Journal of Biological Chemistry.

  

Video: Ken Hsu and Caroline Franks discuss diacylglycerol kinase work

August 2017 | Ken Hsu, assistant professor of chemistry at the University of Virginia, and Caroline Franks, a graduate student in the Hsu lab, discuss their research on diacylglycerol kinases (DGKs). Franks is the first author on the paper "The Ligand Binding Landscape of Diacylglycerol Kinases.”
Read the paper in the journal Cell Chemical Biology.

  

Video: Kyle Korshavn discusses how bilayer thickness regulates Aβ aggregation

June 2017 | Kyle Korshavn, a postdoctoral researcher in Ayyalusamy Ramamoorthy’s lab at the University of Michigan, was first author on a paper reporting how pathologically thin lipid bilayers affect amyloid-β aggregation and how pathological lipid oxidation may contribute to Aβ cytotoxicity.
Read Korshavn’s paper in the Journal of Biological Chemistry. Watch a video of Korshavn talking about his work.

  

Video: Visualization technique reveals unusual shape of VLDL

June 2017 | Yu et al. developed a 3-D technique called individual particle electron tomography, allowing them to visualize the carriers of cholesterol. The research reveals a unique polyhedral shape to very low-density lipoproteins (VLDL), which are implicated in the development of cardiovascular disease. This discovery could direct future studies into how flat faces and sharp edges of these molecules affect cholesterol transport and lead to disease. See the animation on YouTube. Read the paper in the Journal of Lipid Research.

  

Understanding phospholipid function: Why are there so many lipids?

May 2017 | In a scientific memoir, Bill Dowhan describes the arc of his career and how the study of lipids has progressed. Once considered that annoying grease that was disposed of while purifying proteins, lipids, we now know, come in a dazzling array and do much for the cell. The memoir is an inspiring must-read for lipidologists at all stages of their careers by one of the true greats in lipid research.
Read Dowhan’s “Reflections” article in the Journal of Biological Chemistry. Watch a video of him on YouTube.

  

Friction mediates scission of tubular membranes scaffolded by BAR proteins

May 2017 | We’re used to there being friction between the lipid world and the protein world, but little did we know that this friction is an important component of membrane remodeling. Simunovic et al. report that the dynamin-independent scission of endocytic vesicles is driven by the friction generated by the interaction of lipids and BAR-domain proteins.
Read the paper in the journal Cell.

  

ApoE and lipid homeostasis in Alzheimer’s disease: a thematic review series

May 2017 | Besides aging, the most significant known risk factor for Alzheimer’s disease is the ApoE4 allele. ApoE is the major apolipoprotein in the brain, and E4 is a rare variant. This series of eight thematically linked reviews explores the isoform-specific roles ApoE plays in healthy and diseased brain states.
Read the introduction by Ta-Yuan Chang and Catherine Chang in the Journal of Biological Chemistry.

  

Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid

April 2017 | Menon et al. report that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acids via the de novo synthesis of phosphatidic acid, a central metabolite for membrane phospholipid biosynthesis. They show the impact of exogenously supplied fatty acids on mTOR in KRas-driven cancer cells, which are programmed to utilize exogenous lipids.
Read the paper in the Journal of Biological Chemistry.

  

PI-PLC β1 in differentiation and disease

March 2017 | Evidence from several laboratories has highlighted the presence of autonomous nuclear inositol lipid metabolism. The evidence suggests that lipid molecules are important components of signaling pathways operating within the nucleus. The findings are important, given the fact that nuclear signaling activity controls cell growth and differentiation.
Read the rest of this “Lipid News” article by Lucio Cocco in ASBMB Today.

  

Proteins and lipids — a complicated relationship?

January 2017 | Researchers have been discussing for many years the role of the lipid matrix in regulating the activity and the organization of membrane proteins. A variety of effects have been singled out and studied qualitatively and quantitatively in model systems. However, the applicability of those results to living cells is — in many cases — unsatisfactory.
Read the rest of this “Lipid News” article by Eva Sevcsik and Gerhard J. Schütz in ASBMB Today.

  

Effect of H-bond donor lipids on (PI(3,4,5)P3) ionization and clustering

March 2018 | A new paper by the Kooijman lab at Kent State University is out in the Biophysical Journal. “Sometimes we take for granted how mixed lipid systems can alter the ionization and clustering of other lipids,” ASBMB Lipid Research Division co-chair Rob Stahelin of Purdue University said. “This is a great article on how phosphatidylethanolamine and phosphatidylinositol influence the ionization state of the signaling lipid PIP3.”
Read the paper by Graber et al.

  

PKM2 activates nuclear SREBP-1a

March 2018 | SREBPs stimulate lipid biosynthesis through transcriptional activation of lipogenic enzymes, but their roles and interaction partners in cancer cells are not well understood. Here, Zhao et al. shed light on dysregulated lipid metabolism in cancer cells by discovering an interaction between pyruvate kinase M2 and nuclear SREBP1a.
Read the article in the Journal of Biological Chemistry.

  

From the unfolded protein response to metabolic diseases

February 2018 | This review from the Thibault lab at Nanyang Technological University in Singapore covers the exciting finding that the unfolded protein response, an endoplasmic reticulum response to stress, can be triggered by lipid dysregulation. What are the mechanisms for lipid dysregulation sensing?
Read the review by Ho et al. in the Journal of Cell Science.

  

Toward a harmonized field of lipidomics

December 2017 | John Bowden of the National Institute of Standards and Technology talks about a recent paper reporting an exercise to measure the reproducibility of lipidomics analyses across 31 labs in the U.S. and abroad.
Read the Q&A with Bowden in ASBMB Today.

  

The polybasic domain determines lipin phosphoregulation

October 2017 | Lipins are unusual among glycerolipid synthase enzymes because they are not embedded in the endoplasmic reticulum membrane but can transfer between the cytosol and the ER membrane. Researchers in the Harris lab at the University of Virginia investigated why lipin 1 is regulated by phosphorylation but lipin 3 is not.
Read about the work in this “Lipid News” article by Salome Boroda and Thurl Harris in ASBMB Today.

  

PAP controls expression of PSS for phospholipid synthesis

September 2017 | Phosphatidate phosphatase, encoded by the gene PAH1, regulates membrane growth, and, through it, cellular growth capacity. The Carman lab at Rutgers University investigated how PAP affects the expression and activity of other enzymes involved in phospholipid synthesis.
Read the article by Gil-Soo Han and George M. Carman in the Journal of Biological Chemistry.

  

Video: Ken Hsu and Caroline Franks discuss diacylglycerol kinase work

August 2017 | Ken Hsu, assistant professor of chemistry at the University of Virginia, and Caroline Franks, a graduate student in the Hsu lab, discuss their research on diacylglycerol kinases (DGKs). Franks is the first author on the paper "The Ligand Binding Landscape of Diacylglycerol Kinases.”
Read the paper in the journal Cell Chemical Biology.

  

Video: Kyle Korshavn discusses how bilayer thickness regulates Aβ aggregation

June 2017 | Kyle Korshavn, a postdoctoral researcher in Ayyalusamy Ramamoorthy’s lab at the University of Michigan, was first author on a paper reporting how pathologically thin lipid bilayers affect amyloid-β aggregation and how pathological lipid oxidation may contribute to Aβ cytotoxicity.
Read Korshavn’s paper in the Journal of Biological Chemistry. Watch a video of Korshavn talking about his work.

  

Video: Visualization technique reveals unusual shape of VLDL

June 2017 | Yu et al. developed a 3-D technique called individual particle electron tomography, allowing them to visualize the carriers of cholesterol. The research reveals a unique polyhedral shape to very low-density lipoproteins (VLDL), which are implicated in the development of cardiovascular disease. This discovery could direct future studies into how flat faces and sharp edges of these molecules affect cholesterol transport and lead to disease. See the animation on YouTube. Read the paper in the Journal of Lipid Research.

  

Understanding phospholipid function: Why are there so many lipids?

May 2017 | In a scientific memoir, Bill Dowhan describes the arc of his career and how the study of lipids has progressed. Once considered that annoying grease that was disposed of while purifying proteins, lipids, we now know, come in a dazzling array and do much for the cell. The memoir is an inspiring must-read for lipidologists at all stages of their careers by one of the true greats in lipid research.
Read Dowhan’s “Reflections” article in the Journal of Biological Chemistry. Watch a video of him on YouTube.

  

Friction mediates scission of tubular membranes scaffolded by BAR proteins

May 2017 | We’re used to there being friction between the lipid world and the protein world, but little did we know that this friction is an important component of membrane remodeling. Simunovic et al. report that the dynamin-independent scission of endocytic vesicles is driven by the friction generated by the interaction of lipids and BAR-domain proteins.
Read the paper in the journal Cell.

  

ApoE and lipid homeostasis in Alzheimer’s disease: a thematic review series

May 2017 | Besides aging, the most significant known risk factor for Alzheimer’s disease is the ApoE4 allele. ApoE is the major apolipoprotein in the brain, and E4 is a rare variant. This series of eight thematically linked reviews explores the isoform-specific roles ApoE plays in healthy and diseased brain states.
Read the introduction by Ta-Yuan Chang and Catherine Chang in the Journal of Biological Chemistry.

  

Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid

April 2017 | Menon et al. report that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acids via the de novo synthesis of phosphatidic acid, a central metabolite for membrane phospholipid biosynthesis. They show the impact of exogenously supplied fatty acids on mTOR in KRas-driven cancer cells, which are programmed to utilize exogenous lipids.
Read the paper in the Journal of Biological Chemistry.

  

PI-PLC β1 in differentiation and disease

March 2017 | Evidence from several laboratories has highlighted the presence of autonomous nuclear inositol lipid metabolism. The evidence suggests that lipid molecules are important components of signaling pathways operating within the nucleus. The findings are important, given the fact that nuclear signaling activity controls cell growth and differentiation.
Read the rest of this “Lipid News” article by Lucio Cocco in ASBMB Today.

  

Proteins and lipids — a complicated relationship?

January 2017 | Researchers have been discussing for many years the role of the lipid matrix in regulating the activity and the organization of membrane proteins. A variety of effects have been singled out and studied qualitatively and quantitatively in model systems. However, the applicability of those results to living cells is — in many cases — unsatisfactory.
Read the rest of this “Lipid News” article by Eva Sevcsik and Gerhard J. Schütz in ASBMB Today.

  

  
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