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Research Highlights

New and Noteworthy:

Biochemical Membrane Lipidomics during Drosophila Development. Dev. Cell.

Biochemical Membrane Lipidomics during Drosophila Development. Developmental Cell.

Sphingolipids: Regulators of the Crosstalk between Apoptosis and Autophagy. J. Lipid Res.

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol.

Ablation of neuronal Ceramide Synthase 1 in mice decreases ganglioside levels and expression of Myelin Associated Glycoprotein in oligodendrocytes

Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. J Biol Chem.

Phosphatidylinositol-4,5-bisphosphate ionization and domain formation in the presence of lipids with hydrogen bond donor capabilities.

Lipid-Dependent Generation of Dual Topology for a Membrane Protein.

Remodeling of Lipid Vesicles into Cylindrical Micelles by a-synuclein in an Extended a-Helical Conformation.

Effect of temperature on the formation of liquid phase-separating giant unilamellar vesicles (GUV).

Endosomal Sorting Complex Required for Transport (ESCRT) Complexes Induce Phase-separated Microdomains in Supported Lipid Bilayers.

Amino acid addition to Vibrio choleraeLPS establishes a link between surface remodeling in Gram-positive and Gram-negative bacteria

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

Endosomal Sorting Complex Required for Transport (ESCRT) complexes induce phase-separated microdomains in supported lipid bilayers

From the Journal of Biological Chemistry:
Structure of a Potential Antimalarial Drug Target Revealed: Structure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from Malaria Parasite Plasmodium falciparum. Antiparasitic Drug Target
Exogenous Ceramide-1-phosphate Reduces Lipopolysaccharide (LPS)-mediated Cytokine Expression
Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage
Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

From the Journal of Lipid Research:  
Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain
Adipose tissue stem cells meet preadipocyte commitment: going back to the future
Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia
Serum paraoxonase-3 concentration in HIV-infected patients. Evidence for a protective role against oxidation

From Science:
Sheddase Gets Guidance

Journal of Cell Biology:
Sandra Schmid:  Collaring endocytosis
Acid sphingomyelinase deals the seal 

From Cell:
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids

From Nature Chemical Biology:
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Inflammation: Hope for sepsis treatment
Membranes: Migration in cue-less cells
Seeing the future of bioactive lipid drug targets

From Nature Chemistry:
In situ quantitative imaging of cellular lipids using molecular sensors 

From Nature Reviews Drug Discovery: 
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

From Nature Reviews Microbiology:
Severing the bud

Looking for older highlights, check our Archived Research Highlights page

 

Research Highlights

New and Noteworthy:

Biochemical Membrane Lipidomics during Drosophila Development. Dev. Cell.

Biochemical Membrane Lipidomics during Drosophila Development. Developmental Cell.

Sphingolipids: Regulators of the Crosstalk between Apoptosis and Autophagy. J. Lipid Res.

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol.

Ablation of neuronal Ceramide Synthase 1 in mice decreases ganglioside levels and expression of Myelin Associated Glycoprotein in oligodendrocytes

Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. J Biol Chem.

Phosphatidylinositol-4,5-bisphosphate ionization and domain formation in the presence of lipids with hydrogen bond donor capabilities.

Lipid-Dependent Generation of Dual Topology for a Membrane Protein.

Remodeling of Lipid Vesicles into Cylindrical Micelles by a-synuclein in an Extended a-Helical Conformation.

Effect of temperature on the formation of liquid phase-separating giant unilamellar vesicles (GUV).

Endosomal Sorting Complex Required for Transport (ESCRT) Complexes Induce Phase-separated Microdomains in Supported Lipid Bilayers.

Amino acid addition to Vibrio choleraeLPS establishes a link between surface remodeling in Gram-positive and Gram-negative bacteria

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

Endosomal Sorting Complex Required for Transport (ESCRT) complexes induce phase-separated microdomains in supported lipid bilayers

From the Journal of Biological Chemistry:
Structure of a Potential Antimalarial Drug Target Revealed: Structure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from Malaria Parasite Plasmodium falciparum. Antiparasitic Drug Target
Exogenous Ceramide-1-phosphate Reduces Lipopolysaccharide (LPS)-mediated Cytokine Expression
Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage
Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

From the Journal of Lipid Research:  
Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain
Adipose tissue stem cells meet preadipocyte commitment: going back to the future
Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia
Serum paraoxonase-3 concentration in HIV-infected patients. Evidence for a protective role against oxidation

From Science:
Sheddase Gets Guidance

Journal of Cell Biology:
Sandra Schmid:  Collaring endocytosis
Acid sphingomyelinase deals the seal 

From Cell:
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids

From Nature Chemical Biology:
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Inflammation: Hope for sepsis treatment
Membranes: Migration in cue-less cells
Seeing the future of bioactive lipid drug targets

From Nature Chemistry:
In situ quantitative imaging of cellular lipids using molecular sensors 

From Nature Reviews Drug Discovery: 
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

From Nature Reviews Microbiology:
Severing the bud

Looking for older highlights, check our Archived Research Highlights page

 

  

  

 

 

  
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