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Auto-inhibition in a Transcription Factor: An Interview with JBC Author Peter JohnsonJuly 1, 2010--In this podcast, JBC Associate Editor Joan Conaway of the Stowers Institute interviews Paper of the Week author Peter Johnson from the National Cancer Institute about his research on CEPB-β. In his recent JBC paper "CCAAT/enhancer binding protein β DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CBP," he describes this transcription factor's novel auto-inhibitory mechanism and its dual role in oncogenesis and cell senescence. The pair first talk about CEPB-β's normal physiological roles and its interactions with oncogenic ras, a series of techniques used to identify the important regulatory domains and conformational changes that correspond with the activation of this normally inert protein. The interview wraps up with how Johnson's findings might be translated to other important transcription factors and cancer research in general.

Final Thoughts From President Petsko Part 3In the third and final portion of his farewell podcast, Petsko talks about the international nature of biochemistry, including his upcoming term as president of the IUBMB, and gives some final acknowledgments to ASBMB.

Final thoughts from President Petsko Part 2
In this installment, Petsko discusses his unusual research appointment as a co-investigator with Dagmar Ringe as he prepares for a 30th anniversary celebration honoring this scientific pairing. Read his final farewell in the June issue of ASBMB Today.

Final thoughts from President Petsko
In this special three-part podcast, outgoing ASBMB President Gregory Petsko takes some time out of his schedule to speak with Nick Zagorski about a variety of topics. Up first, Petsko discusses the NRC report on Research at the Intersection of the Physical and Life Sciences.
Read his last AToday article.

Thematic Minireview Series: Biochemistry and Hypertension
March 19, 2010--In this podcast we talk to JBC Associate editor Dale Benos about his thematic minireview series on the biochemistry of hypertension. The first minireview in the series, Autophagy in Hypertensive Heart Disease, appears in the March 19th issue of the JBC and four more will be published this spring.
Thematic series page

Histone eviction: An interview with JBC author Jason FishJanuary 26, 2010--In this podcast we hear from JBC paper of the week author Jason Fish. We will discuss his paper, "Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter Histones" and talk in-depth about the diverse research areas it covers such as epigenetics, pulmonary disease, nitric oxide signaling and a novel mechanism for the regulation of transcription. Read the paper in the Jan. 8 edition of the JBC.

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