August 2013
 

A deeper look into cholesterol synthesis


The biosynthesis of cholesterol is a complex process with more than 20 steps. One of the first enzymes is 3-hydroxy-3-methylglutaryl-CoA reductase, also known as HMGCR, the main target of statins. In this article, contributor Swathi Parasuraman writes about a recent minireview in The Journal of Biological Chemistry that describes multiple ways various enzymes other than HMGCR are implicated in the modulation of cholesterol synthesis.

 

Potent antifreeze protein’s structure determined


Contributor Natalie Osayande writes about a recent paper in The Journal of Biological Chemistry, in which researchers reported the crystal structure of the most potent antifreeze protein known, RiAFP, found in a longhorned beetle.

 

James E. Darnell’s “Reflections”


Contributor Joseph P. Tiano gives us a peek at James Darnell's Journal of Biological Chemistry “Reflections” article, which provides a brief history of the discovery of RNA and its role in transcription — plus a bit of career advice.

 

Recent findings on presenilins and signal peptide peptidase


Contributor Dinu Valantin Bălănescu writes about the latest findings on the structure and function of γ-secretase and the signal peptide peptidase, which were highlighted in a recent minireview in The Journal of Biological Chemistry.

 

Thematic series on fat-soluble vitamins begins


Mary L. Chang, publications manager for the Journal of Lipid Research, writes about the launch of a thematic series on fat-soluble vitamins.

 

Protein quantification: by mass spectrometry or Western blotting?


Science writer Rajendrani Mukhopadhyay writes about a recent editorial in the journal Molecular & Cellular Proteomics, which says that the time has come to let the protein-quantification data generated by mass spectrometry stand on their own.

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