April 2012

Are we doing a good job of teaching the groundbreaking research of our predecessors?

Dennis Vance says: "Some will argue that there is already too much to cover when we teach biochemistry and we don’t have time to provide a historical perspective. I don’t buy this argument."


From the inside out

In their Journal of Lipid Research paper, Changming Fang and colleagues at the Cancer Research Center at the Sanford-Burnham Medical Research Institute set out to determine if ileal bile acid binding protein, or IBABP, a cytosolic protein believed to be involved in the absorption of bile acids associated with the processing of dietary fat, is involved with UCDA’s activity in the human body.


Indications of a bright future through science

One source of current and reliable data with which to reinforce both our funding justifications and our education and professional development advice is the biennial Science and Engineering Indicators from the National Science Board.


Navigating the NIH grant-application process

If your career goal is to perform biomedical research, then you should read this article. Here, Sonia C. Flores provides step-by-step instructions and tips for navigating the grant application and review process at the National Institutes of Health.


New JBC podcast: TDP-1, protein homeostasis and aging

ASBMB’s outreach coordinator, Geoff Hunt, interviews Jiou Wang from the Johns Hopkins University. He talks about his group’s “Paper of the Week” in the Journal of Biological Chemistry: “Caenorhabditis elegans RNA-processing Protein TDP-1 Regulates Protein Homeostasis and Lifespan.”


Serum antibodies as biomarkers

The scientific literature contains more than 100,000 reports of biomarkers, but only 43 have been approved by the U.S. Food and Drug Administration for clinical diagnostics. A problem is that most biomarkers are so dilute in blood that detecting them becomes a needle-in-haystack issue. Phillip Stafford and colleagues at Arizona State University and the University of Arizona have instead been pursuing antibodies as disease indicators.


Worm protein provides insight into aging and neurodegeneration

Humans carry an RNA-processing protein called the transactive response DNA-binding protein, or TARDBP/TDP-43. The protein has been linked to a number of neurodegenerative disorders that involve protein misfolding, such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In a recent “Paper of the Week” published in the Journal of Biological Chemistry, Jiou Wang at The Johns Hopkins University and colleagues described a Caenorhabditis elegans model in which they removed the worm version of the TDP-43 protein.

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