This August, Molecular and Cellular Proteomics featured a special issue highlighting the recent progress made at the interface of two exciting research areas: interaction proteomics and structural biology. The general view has emerged that most biological processes involve regulated cooperation between multiple protein partners, and such molecular interactions can be studied from the top-down or bottom-up; large-scale proteomic studies have provided an important catalog of potential protein interaction networks, while in-depth structural and functional characterization of individual proteins and complexes reveals the mechanistic details of the interactions. The special issue features both original research articles and reviews that discuss several emerging technologies, such as combining electron and/or atomic force microscopy with mass spectrometry, which may help bridge the gap between these two approaches and thus paint a more complete picture of the molecular organization of a cell. The papers feature collaborative efforts between scientists of diverse backgrounds using computational, conventional structural biological, and mass spectrometry-based approaches to uncover unique details on the constituency, conformation and assembly dynamics of several large protein assemblies, including the proteasome, ribosome, spliceosome, nuclear pore complex and even whole viruses. The issue also contains articles by Keren Lasker, et al. and John H. Morris, et al. with iSee-enhanced 3-D visualizations.
Bridging the Gap: At the Interface of Proteomics and Structural Biology
Mol. Cell. Proteomics, August 2010
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