June 2010

[JLR] Breeding Fat

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Biobits---JLR-Fat
Offspring of mice who ate a high-fat diet weighed more at the time of weaning and weighed more after eating a high-fat diet.

Obesity has reached epidemic proportions, becoming increasingly common at younger ages. Recent evidence suggests that the unbalanced consumption of different fats, such as a high linoleic acid (LA) to alpha-linolenic acid (LNA) ratio diet, is a risk factor for obesity. Here, the authors examine the effects of transgenerational consumption of a high LA/LNA ratio diet using mice. Mice fed this diet gained weight, a trend that transgressed subsequent generations. The high-fat diet changed the lipid composition in the plasma, adipose tissue and mothers’ milk, increasing LA and arachidonic acid (ARA) while decreasing long-chain polyunsaturated fatty acids, such as eicosapentaenoic (EPA) and docosahexaenoic acids (DHA). While the atypical lipid profile and weight reverted to normal when mice were switched to a standard diet, an incomplete reversion in the epididymal fat pad was observed. Furthermore, the offspring of the mice were heavier at weaning, an effect that persisted despite receiving a standard diet. Altered insulin and adipokine levels and adipocyte cellularity and gene expression profiles were observed between generations and between diet regimen groups. Together, this work establishes a model to examine transgenerational fat mass accumulation, giving insight into possible epigenetic factors associated with this phenomenon.

A Western-like Fat Diet Is Sufficient to Induce a Gradual Enhancement in Fat Mass Over Generations

Florence Massiera, Pascal Barbry, Philippe Guesnet, Aurélie Joly, Serge Luquet, Chiméne Moreilhon-Brest, Tala Mohsen-Kanson, Ez-Zoubir Amri, Gérard Ailhaud

J. Lipid Res., published online April 20, 2010

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