Representative photographs highlighting how 14,21-diHDHA treatment can accelerate wound closure.
Successful wound healing involves the coordination of multiple physiological processes, such as inflammation, cell migration, angiogenesis, formation of granulation tissue and tissue remodeling. A better understanding of the molecular mechanisms behind these processes may provide insight into developing improved wound healing therapies. In this study, the researchers found that cutaneous wounds induced the formation of novel endogenous dihydroxy-docosahexaenoic acid species (14S,21S-diHDHA,14R,21R-diHDHA, 14S,21R-diHDHA and/or 14R,21S-diHDHA). Using mass-spectrometry analysis, they detailed the structures of those novel compounds and the pathways of their formation from DHA by 12-lipoxygenase and cytochrome P450, enzymes found in both the skin and macrophages. Importantly, administration of 14S,21-diHDHA and 14R,21-diHDHA to induced wounds in mice enhanced wound closure, growth of granulation tissue growth and vascular formation. These newly identified 14,21-diHDHA stereoisomers may represent the molecular basis for the healing properties of macrophages and, given their abundance in the skin, may provide an ideal target for developing novel wound-healing therapeutic modalities.
Novel 14,21-dihydroxy-docosahexaenoic Acids: Structures, Formation Pathways, and Enhancement of Wound Healing
Yan Lu, Haibin Tian and Song Hong
J. Lipid Res., published online Nov. 5, 2009
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