The sessions in the "Chemical Biology and Drug Discovery" 2011 annual meeting theme will cover chemical methods to tackle complex problems in biology, advances in the application of peptides as drugs and biological probes, high-throughput methods used in drug discovery and the application of chemical perspectives to the study of disease states. The meeting will be held April 9-13, 2011, in Washington, D.C. (Titled "The Intersection of Chemistry and Biology: Drugs, Disease and Tools for Discovery" in print version.)
|Tamara L. Hendrickson
||Shana O. Kelley
The annual American Society for Biochemistry and Molecular Biology meeting theme “Chemical Biology and Drug Design” will showcase cutting-edge research in areas where chemistry and biology intersect. In four sessions, the molecular mechanisms of disease, the newest approaches to drug discovery for disease treatment and exciting developments in the generation of tools that may shed further light on disease and drug discovery will be highlighted in presentations delivered by leaders in the field.
Tackling Complex Problems in Biology
Each of the speakers in the first session, titled “The Chemical Biologist’s Toolbox,” are applying sophisticated and elegant chemical methods to tackle complex problems in biology.
Christopher J. Chang (University of California, Berkeley) will present his group’s work on the use of cell-permeable fluorescent chemosensors to track reactive oxygen species inside cells in response to environmental triggers, finally providing a means to track radicals in situ. Orthogonal probes also can be used simultaneously to observe the generation of different ROS (e.g. H2O2 and HOCl), allowing the interplay of oxidants to be studied.
Sarah Trimpin (Wayne State University) will discuss how her group merges the capabilities of laser and electrospray ionization methods for solvent-free mass spectrometric analyses of tissue samples to allow the study of site-specific physiological processes at the molecular level.
And, finally, Michael L. Gross (Washington University) will present recent progress on the development of mass spectrometric methods to characterize protein complexes and deconvolve the intricate patterns of interactions that guide biological function.
Each of these presentations will highlight promising new tools that will drive the discovery of new phenomena in biological systems.