Sessions in the ASBMB annual meeting theme "Signal Transduction from the Plasma Membrane to the Nucleus" will look at janus kinase-STAT transcription factors, intracellular signaling, innate immunity and circadian rhythms. The meeting will be held April 9-13, 2011, in Washington, D.C. (Titled "Signaling from the Plasma Membrane to the Nucleus" in print version.)
|Charles E. Samuel
||Karen L. O'Malley
Complex signaling networks govern the function of all cells, allowing them to respond to diverse environmental stimuli and carry out specific cellular tasks. Understanding the molecular mechanisms underlying the vast array of signaling pathways continues to be one of the most intensely studied areas of cell biology. The 2011 annual meeting theme, “Signal Transduction from the Plasma Membrane to the Nucleus,” will explore exciting progress in four areas that span disciplines from microbiology and immunology to neurobiology and physiology.
Janus Kinase-STAT Transcription Factors
On Sunday, April 10, the first session of the theme, titled “STATus of JAKs and STATs in JAK/STAT Signaling,” will examine three aspects of the Janus kinase-STAT transcription factor signaling paradigm. Originally identified as downstream mediators of interferon signaling, four JAKs and seven STATS are utilized in overlapping combinations in signaling by the large family of cytokine receptors.
Sandra Pellegrini (Institut Pasteur) will describe signaling responses elicited by binding of α and β interferons to their cognate receptor. Curt M. Horvath (Northwestern University) will discuss mechanisms by which negative-stranded RNA viruses target STAT proteins and disrupt their signaling activities. STAT factors also play important roles in cell growth and differentiation. John J. O’Shea (National Institutes of Health) will provide insights into T cell differentiation using genome-wide analysis of epigenetic changes and STAT transcription factor binding. As a prelude to this theme, on Saturday, April 9, George Stark, a co-discoverer of the JAK-STAT signaling pathway, will give the Herbert Tabor/Journal of Biological Chemistry Lectureship.
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Although dogma holds that cells respond to extracellular signals via activation of cell surface proteins such as growth factor receptor tyrosine kinases (RTKs) and G protein-coupled receptors, emerging evidence suggests that many of these same channels and receptors function from intracellular locations as well. On April 11, some of these possibilities will be explored during the second signal transduction session, titled “Signaling from New and ‘Arrestin’ Sites.”