At the ASBMB 2011 annual meeting, the "Lipid and Membrane Metabolism" theme will cover phosphoinositides, sphingolipids, phospholipases D and neutral lipids. The meeting will be held April 9-13, 2011, in Washington, D.C. (Titled "Lipids Take Center Stage" in print version.)
|Vytas A. Bankaitis
||Teresa M. Dunn
Distinct chemical families of lipids endow divergent biophysical properties to the membranes in which they reside. Thus, lipid distribution between various intracellular organelles must be properly regulated to insure appropriate membrane function. Many different classes of lipids also are known to serve as metabolic precursors to various second messengers or as signaling molecules in their own right. Because lipid signaling pathways interface with highly interdigitated networks of biological processes, diverse territories of intracellular lipid metabolism and trafficking need to be tightly coordinated. The 2011 American Society for Biochemistry and Molecular Biology annual meeting “Lipid and Membrane Metabolism” theme focuses on new progress regarding how the metabolism, trafficking, organization and biological functions of major lipid classes are coordinated. The theme consists of the following four sessions.
Phosphoinositides are essential signaling lipids that modulate a diverse set of cellular processes. Phosphoinositide metabolism is subject to exquisite spatial and temporal regulation both at the level of synthesis (by lipid kinases) and degradation (by phospholipases and phosphatases). Yet, many aspects of phosphoinositide function remain unclear.
Click here for more 2011 annual meeting thematic overviews.
For information on annual meeting registration, housing and abstract submission, click here.
In the “Current Topics in Phosphoinositide Biology and Signaling” session, Christopher S. Burd (University of Pennsylvania School of Medicine) will discuss his new findings on the roles of phosphatidylinositol-4-phosphate (PtdIns-4-P) in Golgi retrograde trafficking pathways. Julie Brill (The Hospital for Sick Children) will describe her work on physiological functions of PtdIns-4-P production in multicellular organisms using Drosophila as an experimental model.
And, Vytas A. Bankaitis (University of North Carolina School of Medicine) will round out the session by discussing the mechanisms by which PtdIns-transfer proteins act as coincidence detectors for the coupling of disparate pathways from lipid metabolism to production of functionally privileged phosphoinositide signaling pools.